Autophagy and hypoxia in colonic adenomas related to aggressive features

The study investigated whether autophagic activity and hypoxia parallel the adenoma–carcinoma sequence.

[1]  S. Mendrinos,et al.  Patterns of autophagy in urothelial cell carcinomas--the significance of "stone-like" structures (SLS) in transurethral resection biopsies. , 2013, Urologic oncology.

[2]  A. Giatromanolaki,et al.  High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. , 2011, Gynecologic oncology.

[3]  A. Giatromanolaki,et al.  Light-chain 3A autophagic activity and prognostic significance in non-small cell lung carcinomas. , 2011, Chest.

[4]  Y. Eishi,et al.  Autophagy-deficient mice develop multiple liver tumors. , 2011, Genes & development.

[5]  H. Moch,et al.  Automated ERCC1 Immunohistochemistry in Non-small Cell Lung Cancer: Comparison of anti-ERCC1 Antibodies 8F1, D-10, and FL-297 , 2011, Applied immunohistochemistry & molecular morphology : AIMM.

[6]  A. Giatromanolaki,et al.  Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): What is destined for the atypical endometrial hyperplasia? , 2011, Autophagy.

[7]  F. Sinicrope,et al.  Serrated polyps of the colon , 2010, F1000 medicine reports.

[8]  S. Tavaré,et al.  Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression , 2010, Gut.

[9]  A. Harris,et al.  Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas , 2010, Journal of Clinical Pathology.

[10]  A. Giatromanolaki,et al.  Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia , 2010, British Journal of Cancer.

[11]  Nan Li,et al.  Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma. , 2010, World journal of gastroenterology.

[12]  A. Harris,et al.  LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. , 2010, The American journal of pathology.

[13]  J. Pouysségur,et al.  Hypoxia-induced autophagy: cell death or cell survival? , 2010, Current opinion in cell biology.

[14]  D. Chang,et al.  KRAS Mutations in Traditional Serrated Adenomas From Korea Herald an Aggressive Phenotype , 2010, The American journal of surgical pathology.

[15]  D. Hicks,et al.  The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells , 2010, Oncogene.

[16]  S. Danese,et al.  Endoscopic Mucosal Resection for Early Colorectal Neoplasia: Pathologic Basis, Procedures, and Outcomes , 2009, Diseases of the colon and rectum.

[17]  J. Pouysségur,et al.  Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains , 2009, Molecular and Cellular Biology.

[18]  David Y. Lu,et al.  Automated In Situ Hybridization and Immunohistochemistry for Cytomegalovirus Detection in Paraffin-embedded Tissue Sections , 2009, Applied immunohistochemistry & molecular morphology : AIMM.

[19]  D. Ahnen,et al.  Significance of serrated polyps of the colon , 2008, Current gastroenterology reports.

[20]  Robert A Gatenby,et al.  Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. , 2008, Seminars in cancer biology.

[21]  E. Huang Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B and is an independent prognostic factor in resected colorectal cancer: Commentary , 2008 .

[22]  H. Allgayer,et al.  Loss of programmed cell death 4 expression marks adenoma‐carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer , 2007, Cancer.

[23]  S. Cross,et al.  The angiogenic switch occurs at the adenoma stage of the adenoma–carcinoma sequence in colorectal cancer , 2007, Gut.

[24]  Federico Díaz-González,et al.  Up-regulation of gelatinases in the colorectal adenoma-carcinoma sequence. , 2006, European journal of cancer.

[25]  C. Thompson,et al.  Defective autophagy leads to cancer. , 2003, Cancer cell.

[26]  Kyu-Won Kim,et al.  Hypoxia-induced angiogenesis during carcinogenesis. , 2003, Journal of biochemistry and molecular biology.

[27]  A. Harris,et al.  The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages , 2000 .

[28]  J. Bond Colorectal surveillance for neoplasia: an overview. , 1999, Gastrointestinal endoscopy.

[29]  I. Talbot,et al.  Expression of Bcl-2 and p53 in the colorectal adenoma-carcinoma sequence. , 1997, Pathobiology : journal of immunopathology, molecular and cellular biology.

[30]  F. Giardiello,et al.  Phenotype and cancer risk of various polyposis syndromes. , 1995, European journal of cancer.

[31]  S. Antonarakis,et al.  Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Y. Doki,et al.  LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. , 2008, International journal of oncology.

[33]  A. Giatromanolaki,et al.  Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer , 2005, Clinical & Experimental Metastasis.

[34]  A. Harris,et al.  Neoplastic stroma and epithelium show up-regulation of platelet-derived endothelial cell growth factor/thymidine phosphorylase in colorectal carcinomas but not adenomas , 2004, Angiogenesis.