Dimerization-driven degradation of C. elegans and human E proteins

In this study, Sallee et al. demonstrate that E-protein dimer formation can promote C. elegans and human bHLH protein instability. By investigating HLH-2, the sole C. elegans E protein, the authors show that HLH-2 functions as a homodimer for sequential roles in AC specification and differentiation and that the functional dimer is targeted for degradation in VUs, the “opposite” fate. The findings indicate that dimerization-driven regulation of bHLH protein stability may be a conserved mechanism for differential regulation in specific cell contexts.

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