Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
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Lorna M. Lopez | David M. Evans | M. Jarvelin | C. Gieger | T. Spector | I. Deary | L. Wain | N. Shrine | Victoria E. Jackson | I. Ntalla | M. S. Artigas | A. K. Kheirallah | M. Obeidat | Y. Bossé | I. Sayers | P. Deloukas | R. Hubbard | I. Pavord | A. Hansell | N. Thomson | E. Zeggini | A. Morris | J. Marchini | D. Strachan | M. Tobin | I. Hall | T. Lehtimäki | J. González | W. McArdle | D. Nickle | H. Völzke | M. Imboden | D. Jarvis | N. Probst-Hensch | Stefan Enroth | O. Raitakari | J. Hui | J. Beilby | A. James | A. Viñuela | S. Wild | S. Ripatti | E. Ingelsson | L. Lind | I. Rudan | J. Starr | A. C. Alves | N. Wareham | J. Heinrich | I. Surakka | M. Horikoshi | A. Mahajan | J. Ried | H. Grallert | D. Sin | A. Teumer | S. Harris | A. Wright | L. Hocking | D. Evans | L. Lopez | J. Kemp | E. Albrecht | C. Hayward | P. Joshi | I. Kolčić | O. Polašek | V. Vitart | H. Campbell | M. Kähönen | James F. Wilson | J. Marten | S. Padmanabhan | R. Scott | R. Rawal | Ashish Kumar | Å. Johansson | L. Lyytikäinen | A. Hartikainen | J. Zhao | U. Gyllensten | S. Gläser | S. Karrasch | H. Schulz | C. Hammond | P. Navarro | A. Musk | P. Hysi | R. Granell | T. Zemunik | J. Huffman | C. Brandsma | M. Heliövaara | J. Henderson | N. Hutri-Kähönen | C. Flexeder | Victoria E Jackson | E. Mélen | B. Stubbe | Suzanne Miller | H. Trochet | Panos Anna L. Richard Victoria E. Jonathan Ian Neil C. E Deloukas Hansell Hubbard Jackson Marchini P | V. Jackson | M. Heliövaara | M. Artigas | A. Wright | M. Kähönen | R. Scott | David M. Evans | Abdul Kader Kheirallah | J. Heinrich | A. Morris | R. Scott | A. Wright | S. Harris | R. Scott | David M. Evans | A. Wright | D. Jarvis | A. Morris
[1] L. Wain,et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank , 2015, The Lancet. Respiratory medicine.
[2] D. Rifkin,et al. Function of Latent TGFβ Binding Protein 4 and Fibulin 5 in Elastogenesis and Lung Development , 2015, Journal of cellular physiology.
[3] Rutao Cui,et al. The Anti-proliferative Function of the TGF-β1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3* , 2014, The Journal of Biological Chemistry.
[4] S. Kathiresan,et al. Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease , 2014, Circulation. Cardiovascular genetics.
[5] Ross M. Fraser,et al. Defining the role of common variation in the genomic and biological architecture of adult human height , 2014, Nature Genetics.
[6] W. Talbot,et al. Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126 , 2014, Science Signaling.
[7] M. Lag,et al. AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells , 2014, Cell Communication and Signaling.
[8] Y. Bossé,et al. A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD , 2014, Thorax.
[9] Lorna M. Lopez,et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity , 2014, Nature Genetics.
[10] Matthew A. Hibbs,et al. Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment , 2014, PLoS genetics.
[11] Christoph Lange,et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. , 2014, The Lancet. Respiratory medicine.
[12] J. Shendure,et al. A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.
[13] Hui Shen,et al. Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. , 2014, Human molecular genetics.
[14] Peggy Hall,et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..
[15] L. Wain,et al. GSTCD and INTS12 Regulation and Expression in the Human Lung , 2013, PloS one.
[16] M. Peters,et al. Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.
[17] Don D. Sin,et al. Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls , 2013, PloS one.
[18] I. Petrache,et al. Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models , 2013, PloS one.
[19] Avrum Spira,et al. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. , 2013, American journal of respiratory and critical care medicine.
[20] Ellen T. Gelfand,et al. The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.
[21] Christian Gieger,et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture , 2013, Nature Genetics.
[22] Lorna M. Lopez,et al. A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function , 2013, PLoS genetics.
[23] Bernadette A. Thomas,et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.
[24] Bernadette A. Thomas,et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.
[25] David Haussler,et al. ENCODE Data in the UCSC Genome Browser: year 5 update , 2012, Nucleic Acids Res..
[26] D. Lawlor,et al. Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children , 2012, International journal of epidemiology.
[27] Kenny Q. Ye,et al. An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.
[28] Edwin K Silverman,et al. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. , 2012, American journal of respiratory and critical care medicine.
[29] J. Marchini,et al. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.
[30] P. Visscher,et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.
[31] P. Donnelly,et al. The role of ATM in response to metformin treatment and activation of AMPK. , 2012, Nature genetics.
[32] L. Edwards,et al. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. , 2012, Human molecular genetics.
[33] Christian Fuchsberger,et al. GWAtoolbox: an R package for fast quality control and handling of genome-wide association studies meta-analysis data , 2012, Bioinform..
[34] Greg Gibson,et al. Rare and common variants: twenty arguments , 2012, Nature Reviews Genetics.
[35] M. Knuiman,et al. Are Cardiovascular Risk Calculators Derived from General Adult Population Cohorts also Suitable for the Elderly? Results from the Busselton Health Study , 2012 .
[36] Jeffrey E. Lee,et al. Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3 , 2011, Nature Genetics.
[37] Blair H. Smith,et al. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. , 2011, American journal of respiratory and critical care medicine.
[38] Christian Gieger,et al. Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function , 2011, Nature Genetics.
[39] N. Laird,et al. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. , 2011, American journal of respiratory cell and molecular biology.
[40] F. Gianfrancesco,et al. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone , 2011, Nature Genetics.
[41] Vincent J Carey,et al. Expression analysis of asthma candidate genes during human and murine lung development , 2011, Respiratory research.
[42] E. Lundberg,et al. Towards a knowledge-based Human Protein Atlas , 2010, Nature Biotechnology.
[43] T. Langenhan,et al. The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse , 2010, PloS one.
[44] Ayellet V. Segrè,et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.
[45] Ayellet V. Segrè,et al. Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits , 2010, PLoS genetics.
[46] Inês Barroso,et al. Genome-wide association study identifies five loci associated with lung function , 2010, Nature Genetics.
[47] C. Gieger,et al. Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior , 2010, Nature Genetics.
[48] P. Bork,et al. A method and server for predicting damaging missense mutations , 2010, Nature Methods.
[49] Christoph Lange,et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease , 2010, Nature Genetics.
[50] A. Hofman,et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function , 2010, Nature Genetics.
[51] C. Gieger,et al. Sequence variants at CHRNB 3 – CHRNA 6 and CYP 2 A 6 affect smoking behavior , 2010 .
[52] A. Nicholson,et al. Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis , 2009, European Respiratory Journal.
[53] Judy H. Cho,et al. Finding the missing heritability of complex diseases , 2009, Nature.
[54] P. Donnelly,et al. A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.
[55] K. Shianna,et al. A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci , 2009, PLoS genetics.
[56] Scott T. Weiss,et al. A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study , 2009, PLoS genetics.
[57] S. Henikoff,et al. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm , 2009, Nature Protocols.
[58] G. Pazour,et al. The Golgin GMAP210/TRIP11 Anchors IFT20 to the Golgi Complex , 2008, PLoS genetics.
[59] B. Maher. Personal genomes: The case of the missing heritability , 2008, Nature.
[60] C. Gieger,et al. Identification of ten loci associated with height highlights new biological pathways in human growth , 2008, Nature Genetics.
[61] B. Maher,et al. The case of the missing heritability , 2008 .
[62] R. Hopkins,et al. Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes , 2007, European Respiratory Journal.
[63] M. Post,et al. Hypoxia-inducible Factors in the First Trimester Human Lung , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[64] C. D. Mathers,et al. Chronic obstructive pulmonary disease: current burden and future projections , 2006, European Respiratory Journal.
[65] T. Akiyama,et al. DREG, a developmentally regulated G protein‐coupled receptor containing two conserved proteolytic cleavage sites , 2004, Genes to cells : devoted to molecular & cellular mechanisms.
[66] J. Otte,et al. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. , 2002, Genes & development.
[67] W. Bailey,et al. Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution , 2023, Medical science monitor : international medical journal of experimental and clinical research.
[68] P. Burton,et al. Familial aggregation and heritability of adult lung function: results from the Busselton Health Study. , 2001, The European respiratory journal.
[69] M. Province,et al. Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study , 2000, Genetic epidemiology.
[70] K. Roeder,et al. Genomic Control for Association Studies , 1999, Biometrics.
[71] P. Enright,et al. Long-term particulate and other air pollutants and lung function in nonsmokers. , 1998, American journal of respiratory and critical care medicine.
[72] V M Hawthorne,et al. Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study , 1996, BMJ.
[73] Shigenobu Nakamura,et al. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1 , 1994, Nature Genetics.