Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets.
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[1] M. Daly,et al. Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology , 2011, PLoS genetics.
[2] R. Melamed,et al. Gene expression microarrays: glimpses of the immunological genome , 2006, Nature Immunology.
[3] P. Deloukas,et al. Common Regulatory Variation Impacts Gene Expression in a Cell Type–Dependent Manner , 2009, Science.
[4] Timothy J. Durham,et al. "Systematic" , 1966, Comput. J..
[5] C. Benoist,et al. Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis , 2002, Science.
[6] Alkes L. Price,et al. Single-Tissue and Cross-Tissue Heritability of Gene Expression Via Identity-by-Descent in Related or Unrelated Individuals , 2011, PLoS genetics.
[7] Olle Melander,et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus , 2010, Nature.
[8] G. Burmester,et al. Macrophages in rheumatoid arthritis , 2000, Arthritis research.
[9] M. Petri,et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial , 2011, The Lancet.
[10] Richard W. Farndale,et al. Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production , 2010, Science.
[11] G. Williams,et al. Hypothalamic obesity in humans: what do we know and what can be done? , 2002, Obesity reviews : an official journal of the International Association for the Study of Obesity.
[12] Alexander A. Morgan,et al. FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease , 2008, Genome Biology.
[13] Jing Cui,et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci , 2010, Nature Genetics.
[14] Joshua M. Stuart,et al. MICROARRAY EXPERIMENTS : APPLICATION TO SPORULATION TIME SERIES , 1999 .
[15] J. Bluestone,et al. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. , 2007, Nature.
[16] J. Mesirov,et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.
[17] Ying Wang,et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus , 2009, Nature Genetics.
[18] Geoffrey Hom,et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. , 2008, The New England journal of medicine.
[19] K. Clément,et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction , 1998, Nature.
[20] Ayellet V. Segrè,et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.
[21] Soumya Raychaudhuri,et al. Recent advances in the genetics of rheumatoid arthritis , 2010, Current opinion in rheumatology.
[22] C. Wijmenga,et al. Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. , 2006, American journal of human genetics.
[23] Matthew Hardy,et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource , 2009, Nature Genetics.
[24] M. Shlomchik,et al. The central and multiple roles of B cells in lupus pathogenesis , 1999, Immunological reviews.
[25] J. Stone,et al. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. , 2005, Blood.
[26] Sandra D'Alfonso,et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus , 2008, Nature Genetics.
[27] P. Visscher,et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.
[28] M. Daly,et al. Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions , 2009, PLoS genetics.
[29] Ash A. Alizadeh,et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.
[30] Tariq Ahmad,et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci , 2010, Nature Genetics.
[31] D. Jewell,et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation , 2010, Nature Medicine.
[32] Paul M. Allen,et al. Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis1 , 2001, The Journal of Immunology.
[33] Gerald McGwin,et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus , 2009, Nature Genetics.
[34] Tanya M. Teslovich,et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .
[35] S. Batalov,et al. A gene atlas of the mouse and human protein-encoding transcriptomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[36] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.
[37] F. Collins,et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.
[38] P. Donnelly,et al. A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome , 2005, Science.
[39] Robert M. Plenge,et al. Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci , 2011, PLoS genetics.
[40] Judy H Cho,et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease , 2008, Nature Genetics.
[41] Xia Yang,et al. Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes , 2010, PLoS genetics.
[42] Judy H. Cho,et al. The genetics and immunopathogenesis of inflammatory bowel disease , 2008, Nature Reviews Immunology.
[43] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[44] Marta E Alarcón-Riquelme,et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci , 2008, Nature Genetics.
[45] P. Robbins,et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints , 2009, Nature Medicine.
[46] H. Hobbs,et al. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia , 1992, Human mutation.
[47] Christian Gieger,et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation , 2009, Nature Genetics.
[48] D. Clayton,et al. Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes , 2009, Nature Genetics.
[49] Joshua M. Korn,et al. Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function , 2010, PLoS genetics.
[50] G. Firestein. Evolving concepts of rheumatoid arthritis , 2003, Nature.
[51] Nathaniel D. Heintzman,et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.
[52] S. Carding,et al. Inflammatory bowel disease: cause and immunobiology , 2007, The Lancet.