IFN‐γ but not IL‐4 T cells of the asthmatic bronchial wall show increased incidence of apoptosis

Background Previous observations have established that IFN‐γ production is depressed in CD4+ T cells from atopic asthmatics compared with non‐asthmatics.

[1]  J. Bousquet,et al.  Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis. , 1999, The Journal of allergy and clinical immunology.

[2]  N. Krug,et al.  Enhanced expression of fas ligand (CD95L) on T cells after segmental allergen provocation in asthma. , 1999, The Journal of allergy and clinical immunology.

[3]  M. Holtzman,et al.  Resistance to Fas-mediated T cell apoptosis in asthma. , 1999, Journal of immunology.

[4]  I. Tillie‐Leblond,et al.  Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics. , 1998, American journal of respiratory cell and molecular biology.

[5]  J. Faul,et al.  Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time , 1998, Thorax.

[6]  F. Grignani,et al.  Defective Expression of Fas Messenger RNA and Fas Receptor on Pulmonary T Cells from Patients with Asthma , 1998, Annals of Internal Medicine.

[7]  L. Poulter,et al.  Allergen-induced cytokine production in atopic disease and its relationship to disease severity. , 1997, American journal of respiratory cell and molecular biology.

[8]  Takashi Saito,et al.  Th1 and Th2 subsets equally undergo Fas‐dependent and ‐independent activation‐induced cell death , 1997, European journal of immunology.

[9]  D. Umetsu,et al.  TH1 and TH2 CD4+ cells in human allergic diseases. , 1997, The Journal of allergy and clinical immunology.

[10]  D. Green,et al.  Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis , 1997, The Journal of experimental medicine.

[11]  B. Schmekel,et al.  Relative effects of inhaled corticosteroids on immunopathology and physiology in asthma: a controlled study. , 1996, Thorax.

[12]  A. J. Wilson,et al.  Eosinophil apoptosis and the resolution of airway inflammation in asthma. , 1996, American journal of respiratory and critical care medicine.

[13]  T. Yokota,et al.  Expression of the Fas ligand in cells of T cell lineage. , 1995, Journal of immunology.

[14]  F. Ramsdell,et al.  Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. , 1994, International immunology.

[15]  W. Luttmann,et al.  Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II). , 1994, The European respiratory journal.

[16]  R. Coffman,et al.  Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell- mediated immunity , 1994, The Journal of experimental medicine.

[17]  C. Haslett.  Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. , 1992, Clinical science.

[18]  H. Bielefeldt-Ohmann,et al.  Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. , 1992, Science.

[19]  J. Virchow,et al.  Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. , 1992, The American review of respiratory disease.

[20]  S. Durham,et al.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. , 1992, The New England journal of medicine.

[21]  B. Schmekel,et al.  Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. , 1992, The European respiratory journal.

[22]  S. Durham,et al.  Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. , 1991, The Journal of allergy and clinical immunology.

[23]  C. Corrigan,et al.  CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. , 1990, The American review of respiratory disease.

[24]  L. Zheng,et al.  Autocrine feedback death and the regulation of mature T lymphocyte antigen responses. , 1995, International reviews of immunology.

[25]  W. Luttmann,et al.  Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I). , 1994, The European respiratory journal.

[26]  C. Corrigan,et al.  T cells and eosinophils in the pathogenesis of asthma. , 1992, Immunology today.

[27]  E. R. Mcfadden,et al.  Medical progress : asthma , 1992 .

[28]  G. Del Prete.  Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. , 1992, Allergy.