This article focuses on the research of a general time-varying nonlinear optimization (TVNO) problem solving especially in a noise-disturbance environment. For addressing this problem more efficiently, a new noise-enduring and finite-time convergent design formula is suggested to establish a novel zeroing neural network (NZNN). In contrast to the initial zeroing neural network or the noising-enduring zeroing neural network, which either only achieves finite-time convergence or only suppresses external disturbances, the merit of the proposed NZNN model is able to find an error-free optimal solution in a finite time under various different types of external noises. In addition, the detailed mathematical analyses about finite-time convergence and noise endurance are given to prove the excellent characteristics of the NZNN model. Numerical comparative results are provided to demonstrate the accuracy, efficiency, and advantages of the NZNN model for TVNO under various types of external disturbances. Robotic tracking example further validates the applicability of the NZNN model especially in a noise-disturbance environment.