Antihypertensive Activities of a Philippine Wild Edible White Rot Fungus (Lentinus sajor-caju) in Spontaneously Hypertensive Rats as Models

This paper highlights the antihypertensive effects of Lentinus sajor-caju, a wild edible white rot mushroom. The 6-week old male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) were orally administered with 1 ml/100g of body weight of the prepared extract concentrations (0.0 mg/kg, 38.5 mg/kg, and 77.0 mg/kg dosages) of L. sajor-caju once-daily for 16 weeks. The blood pressure and heart rate were monitored once a week and blood of mice was drawn at the end of the experiment for blood chemistry analyses. Results revealed that hot water extract of L. sajor-caju (WELS), was found to exhibit lowering effects in the systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate when orally administered to SHR. The antihypertensive actions of WELS were also demonstrated by improve metabolic activities as indicated by the blood chemistry clearance. WELS at 38.5 mg/kg or higher dose significantly lowered the values of triglycerides (TG), blood urea nitrogen (BUN) and creatinine (Cre), and significantly increased the values of total cholesterol (T-Cho), high-density lipoprotein-cholesterol (HDL-C), albumin/globulin ratio (A/G ratio) in SHR. Therefore, WELS has a promising contribution in the prevention of hypertension development.

[1]  N. Miyazawa,et al.  Effects of a Hot-Water Extract of Porcini (Boletus aestivalis) Mushrooms on the Blood Pressure and Heart Rate of Spontaneously Hypertensive Rats , 2013, Bioscience, biotechnology, and biochemistry.

[2]  Tomoko Seyama,et al.  Philippine Native and Exotic Species of Edible Mushrooms Grown on Rice-Straw-Based Formulation Exhibit Nutraceutical Properties , 2013 .

[3]  Vasudha Singh,et al.  Medicinal Properties of Pleurotus Species (Oyster Mushroom): A Review , 2012 .

[4]  M. Kang,et al.  Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. , 2011, Journal of agricultural and food chemistry.

[5]  Y. Komiyama,et al.  The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin–angiotensin–aldosterone system, oxidative stress and endogenous digitalis in the brain , 2011, Hypertension Research.

[6]  K. Yoon,et al.  Pleurotus nebrodensis Ameliorates Atherogenic Lipid and Histological Function in Hypercholesterolemic Rats , 2011 .

[7]  M. Foulongne-Oriol,et al.  Characterization of antihypertensive peptides from Pleurotus cystidiosus O.K. Miller (abalone mushroom). , 2011 .

[8]  S. Wasser.  Current findings, future trends, and unsolved problems in studies of medicinal mushrooms , 2011, Applied Microbiology and Biotechnology.

[9]  S. Kjeldsen,et al.  High heart rate as predictor of essential hypertension: the hyperkinetic state, evidence of prediction of hypertension, and hemodynamic transition to full hypertension. , 2009, Progress in cardiovascular diseases.

[10]  R. Reyes,et al.  Coprinus comatus , a newly domesticated wild nutriceutical mushroom in the Philippines , 2009 .

[11]  M. Okazaki,et al.  Antihypertensive effect of Pleurotus nebrodensis in spontaneously hypertensive rats. , 2008, Journal of oleo science.

[12]  H. D. Anderson,et al.  Effect of Dietary Chromium on Resistance Artery Function and Nitric Oxide Signaling in the Sucrose-Fed Spontaneously Hypertensive Rat , 2007, Journal of Vascular Research.

[13]  Y. Yamori,et al.  Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. , 2005, European journal of pharmacology.

[14]  Y. Furuichi,et al.  Effect of Frying with Edible Oil on Antihypertensive Properties of Hatakeshimeji (Lyophyllum decastes Sing.) Mushroom , 2005 .

[15]  Y. Tamai,et al.  A Phytochemical in the Edible Tamogi-take Mushroom (Pleurotus cornucopiae), D-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats , 2005, Bioscience, biotechnology, and biochemistry.

[16]  D. Bagchi,et al.  Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains , 2002, Molecular and Cellular Biochemistry.

[17]  S. Wasser.  Wasser Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides , 2022 .

[18]  佐藤 拓,et al.  Antihypertensive Effect of an Aqueous Extract from Fruit Body of Mycoleptodonoides aitchisonii in Spontaneously Hypertensive Rats , 2001 .

[19]  F. Eguchi.  Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats , 1999 .

[20]  D. Abernethy,et al.  Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium , 1997, Journal of hypertension.

[21]  H. Preuss,et al.  Effects of high sugar diets on renal fluid, electrolyte and mineral handling in rats: relationship to blood pressure. , 1994, Journal of the American College of Nutrition.

[22]  S. Kimura,et al.  Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). , 1988, Journal of nutritional science and vitaminology.

[23]  K. Fung,et al.  Hypotensive and renal effects of an extract of the edible mushroom Pleurotus sajor-caju. , 1986, Life sciences.