MacaquesVirus Replication in Mauritian Cynomolgus with Control of Simian Immunodeficiency T Cell Responses Correlate + Specific CD8

Specific major histocompatibility complex (MHC) class I alleles are associated with an increased frequency of spontaneous con-trol of human and simian immunodeficiency viruses (HIV and SIV). The mechanism of control is thought to involve MHC class I-restricted CD8 (cid:1) T cells, but it is not clear whether particular CD8 (cid:1) T cell responses or a broad repertoire of epitope-specific CD8 (cid:1) T cell populations (termed T cell breadth) are principally responsible for mediating immunologic control. To test the hypothesis that heterozygous macaques control SIV replication as a function of superior T cell breadth, we infected MHC-homozy-gous and MHC-heterozygous cynomolgus macaques with the pathogenic virus SIVmac239. As measured by a gamma interferon enzyme-linked immunosorbent

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