Progesterone receptor transcription and non-transcription signaling mechanisms

[1]  D. Edwards,et al.  Mechanism of Action of Progesterone Antagonists , 2002, Experimental biology and medicine.

[2]  D. Edwards,et al.  Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator , 2002, Molecular and Cellular Biology.

[3]  B. Katzenellenbogen,et al.  Defining the "S" in SERMs , 2002, Science.

[4]  Neil J. McKenna,et al.  Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators , 2002, Cell.

[5]  K. Horwitz,et al.  Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells* , 2002, The Journal of Biological Chemistry.

[6]  D. Edwards,et al.  Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. , 2001, Molecular cell.

[7]  J. Ruderman,et al.  Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  N. Weigel,et al.  8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein , 2000, Molecular and Cellular Biology.

[9]  Y. Sheng,et al.  The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  J. A. Kemppainen,et al.  FXXLF and WXXLF Sequences Mediate the NH2-terminal Interaction with the Ligand Binding Domain of the Androgen Receptor* , 2000, The Journal of Biological Chemistry.

[11]  D. F. Smith,et al.  Molecular chaperone interactions with steroid receptors: an update. , 2000, Molecular endocrinology.

[12]  C. Glass,et al.  The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.

[13]  D. Edwards,et al.  Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor , 2000, The Journal of the Society for Gynecologic Investigation: JSGI.

[14]  J E Ferrell,et al.  Xenopus oocyte maturation: new lessons from a good egg. , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[15]  D. Edwards,et al.  Coregulatory proteins in steroid hormone receptor action: The role of chromatin high mobility group proteins HMG-1 and -2 , 1999, Steroids.

[16]  D. Edwards,et al.  Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. , 1999, Molecular endocrinology.

[17]  J. Kuriyan,et al.  Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. , 1999, Molecular cell.

[18]  S. Harrison,et al.  Crystal structures of c-Src reveal features of its autoinhibitory mechanism. , 1999, Molecular cell.

[19]  Neil J McKenna,et al.  A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex , 1999, Cell.

[20]  D. Edwards,et al.  Agonist and antagonists induce homodimerization and mixed ligand heterodimerization of human progesterone receptors in vivo by a mammalian two-hybrid assay. , 1998, Molecular endocrinology.

[21]  P. Sigler,et al.  Atomic structure of progesterone complexed with its receptor , 1998, Nature.

[22]  P B Sigler,et al.  Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[23]  D. Edwards,et al.  The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors* , 1998, The Journal of Biological Chemistry.

[24]  M. Bagchi,et al.  A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor. , 1998, Molecular endocrinology.

[25]  Wen-rong Gong,et al.  Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross‐talk with estrogen receptor , 1998, The EMBO journal.

[26]  R. Sutherland,et al.  Mechanisms of Cyclin-Dependent Kinase Inactivation by Progestins , 1998, Molecular and Cellular Biology.

[27]  D. Edwards,et al.  The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation. , 1998, Endocrinology.

[28]  N. Weigel,et al.  The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor , 1998, Molecular and Cellular Biology.

[29]  K. Horwitz,et al.  The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. , 1997, Molecular endocrinology.

[30]  J. Kuriyan,et al.  Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement , 1997, Nature.

[31]  D. Edwards,et al.  16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  A. Bamberger,et al.  Modulation of AP-1 activity by the human progesterone receptor in endometrial adenocarcinoma cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. T. Brown,et al.  Regulation, substrates and functions of src. , 1996, Biochimica et biophysica acta.

[34]  E. Kalkhoven,et al.  Negative Interaction between the RelA(p65) Subunit of NF-B and the Progesterone Receptor (*) , 1996, The Journal of Biological Chemistry.

[35]  B. Katzenellenbogen,et al.  Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[36]  B. O’Malley,et al.  Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily , 1995, Science.

[37]  D. Edwards,et al.  Progesterone receptor and the mechanism of action of progesterone antagonists , 1995, The Journal of Steroid Biochemistry and Molecular Biology.

[38]  K. Horwitz,et al.  A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. , 1994, Molecular endocrinology.

[39]  K. Horwitz,et al.  Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. , 1993, Molecular endocrinology.

[40]  D. Edwards,et al.  The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. , 1993, Endocrinology.

[41]  E. Milgrom,et al.  In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  K. Horwitz,et al.  Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. , 1993, The Journal of biological chemistry.

[43]  B. O’Malley,et al.  Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[44]  B. O’Malley,et al.  Identification of a negative regulatory function for steroid receptors. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[45]  D. Edwards,et al.  Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor. , 1992, Biochemistry.

[46]  P. Chambon,et al.  A single amino acid that determines the sensitivity of progesterone receptors to RU486. , 1992, Science.

[47]  D. F. Skafar Differences in the binding mechanism of RU486 and progesterone to the progesterone receptor. , 1991, Biochemistry.

[48]  G. Ryffel,et al.  Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. , 1991, Nucleic acids research.

[49]  P. Chambon,et al.  Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. , 1990, The EMBO journal.

[50]  P Chambon,et al.  Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. , 1990, The EMBO journal.

[51]  E. Baulieu,et al.  Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor. , 1990, Science.

[52]  D. Edwards,et al.  Mapping contacts between unpurified human progesterone receptor and the hormone response element of mouse mammary tumor virus. , 1989, DNA.

[53]  D. Edwards,et al.  Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered form. , 1989, Molecular endocrinology.

[54]  E. Baulieu Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor , 1989 .

[55]  G. Chalepakis,et al.  Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus , 1988, Cell.

[56]  J. Brosens,et al.  Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells. , 2002, Molecular endocrinology.

[57]  P. Giangrande,et al.  The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. , 1999, Recent progress in hormone research.

[58]  D. Edwards,et al.  Coregulatory proteins in nuclear hormone receptor action. , 1999, Vitamins and hormones.

[59]  Sheila M. Thomas,et al.  Cellular functions regulated by Src family kinases. , 1997, Annual review of cell and developmental biology.

[60]  B. O’Malley,et al.  Molecular mechanisms of action of steroid/thyroid receptor superfamily members. , 1994, Annual review of biochemistry.

[61]  B. McEwen,et al.  Non-genomic and genomic effects of steroids on neural activity. , 1991, Trends in pharmacological sciences.