Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase‐13 promoter activation

[1]  M. Seno,et al.  Involvement of MAPK signaling molecules and Runx2 in the NELL1‐induced osteoblastic differentiation , 2008, FEBS letters.

[2]  Renny T. Franceschi,et al.  Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development , 2007, The Journal of cell biology.

[3]  N. Selvamurugan,et al.  Overexpression of Runx2 directed by the matrix metalloproteinase‐13 promoter containing the AP‐1 and Runx/RD/Cbfa sites alters bone remodeling in vivo , 2006, Journal of cellular biochemistry.

[4]  Andrés J. García,et al.  Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation , 2006, Journal of Cell Science.

[5]  G. Stein,et al.  Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Mahboob Rahman,et al.  Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Coffman Runx transcription factors and the developmental balance between cell proliferation and differentiation , 2003, Cell biology international.

[8]  A. Geiser,et al.  Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling. , 2003, Molecular endocrinology.

[9]  B. Riggs,et al.  Changes in Runx2/Cbfa1 Expression and Activity During Osteoblastic Differentiation of Human Bone Marrow Stromal Cells , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  Yoshiaki Ito,et al.  Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms , 2002, EMBO reports.

[11]  Yoshiaki Ito,et al.  Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin–proteasome‐mediated degradation , 2001, The EMBO journal.

[12]  D. Tyson,et al.  Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1* , 2000, The Journal of Biological Chemistry.

[13]  G. Karsenty,et al.  Inhibition of Osteoblast-specific Transcription Factor Cbfa1 by the cAMP Pathway in Osteoblastic Cells , 1999, The Journal of Biological Chemistry.

[14]  S. Krane,et al.  Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. , 1999, The Journal of clinical investigation.

[15]  N. Selvamurugan,et al.  Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence* , 1998, The Journal of Biological Chemistry.

[16]  K Yano,et al.  Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[17]  G. Stein,et al.  Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone‐specific complex , 1997, Journal of cellular biochemistry.

[18]  S. Mundlos,et al.  Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development , 1997, Cell.

[19]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[20]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[21]  S. Baekkeskov,et al.  Phosphorylation of Serine Residues 3, 6, 10, and 13 Distinguishes Membrane Anchored from Soluble Glutamic Acid Decarboxylase 65 and Is Restricted to Glutamic Acid Decarboxylase 65α* , 1997, The Journal of Biological Chemistry.

[22]  K. Tanaka,et al.  The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability , 1996, Molecular and cellular biology.

[23]  Jack P. Witty,et al.  Parathyroid hormone‐induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[24]  J. Clohisy,et al.  Parathyroid hormone induces transcription of collagenase in rat osteoblastic cells by a mechanism using cyclic adenosine 3',5'-monophosphate and requiring protein synthesis. , 1992, Molecular endocrinology.

[25]  J. Delaisse,et al.  Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue. , 1988, Endocrinology.

[26]  S. Teitelbaum,et al.  Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells. , 1987, Endocrinology.

[27]  S. K. Zaidi,et al.  Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. , 2004, Critical reviews in eukaryotic gene expression.

[28]  M. Reiss,et al.  Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. , 2004, The Journal of biological chemistry.

[29]  G. Xiao,et al.  Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. , 2003, Connective tissue research.

[30]  J. Westendorf,et al.  Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia , 1999, Journal of cellular biochemistry.