Molecular biology of human apolipoprotein B and related diseases.

[1]  W. Kannel,et al.  Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. , 2020, Annals of internal medicine.

[2]  S. Young,et al.  Lipoprotein B37, a naturally occurring lipoprotein containing the amino-terminal portion of apolipoprotein B100, does not bind to the apolipoprotein B,E (low density lipoprotein) receptor. , 1987, The Journal of biological chemistry.

[3]  R. Mahley,et al.  Structural relationship of human apolipoprotein B48 to apolipoprotein B100. , 1987, The Journal of clinical investigation.

[4]  Z W Gu,et al.  Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. , 1987, Science.

[5]  S. Grundy,et al.  Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[6]  R. Pease,et al.  A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine , 1987, Cell.

[7]  R. Jackson,et al.  Isolation and characterization of four heparin-binding cyanogen bromide peptides of human plasma apolipoprotein B. , 1987, Biochemistry.

[8]  K. Weisgraber,et al.  Human apolipoprotein B-100 heparin-binding sites. , 1987, The Journal of biological chemistry.

[9]  S. Young,et al.  Characterization of an abnormal species of apolipoprotein B, apolipoprotein B-37, associated with familial hypobetalipoproteinemia. , 1987, The Journal of clinical investigation.

[10]  S. Young,et al.  Genetic analysis of a kindred with familial hypobetalipoproteinemia. Evidence for two separate gene defects: one associated with an abnormal apolipoprotein B species, apolipoprotein B-37; and a second associated with low plasma concentrations of apolipoprotein B-100. , 1987, The Journal of clinical investigation.

[11]  T. Hughes,et al.  A novel cell line (Caco-2) for the study of intestinal lipoprotein synthesis. , 1987, The Journal of biological chemistry.

[12]  W. A. Bradley,et al.  Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100 , 1986, Nature.

[13]  D. Atkinson,et al.  The complete sequence and structural analysis of human apolipoprotein B‐100: relationship between apoB‐100 and apoB‐48 forms. , 1986, The EMBO journal.

[14]  R. Pease,et al.  Structure of the human apolipoprotein B gene. , 1986, The Journal of biological chemistry.

[15]  H. Brewer,et al.  Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[16]  S. Grundy,et al.  In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia. , 1986, The Journal of clinical investigation.

[17]  R. Mahley,et al.  Complete protein sequence and identification of structural domains of human apolipoprotein B , 1986, Nature.

[18]  J. Borén,et al.  Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells. , 1986, The Journal of biological chemistry.

[19]  R. Nicolosi,et al.  Complementary DNA derived structure of the amino-terminal domain of human apolipoprotein B and size of its messenger RNA transcript. , 1986, Biochemistry.

[20]  S. Young,et al.  Parallel expression of the MB19 genetic polymorphism in apoprotein B-100 and apoprotein B-48. Evidence that both apoproteins are products of the same gene. , 1986, The Journal of biological chemistry.

[21]  J. Kane,et al.  Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[22]  T. Forte,et al.  Characterization of lipoproteins produced by the human liver cell line, Hep G2, under defined conditions. , 1986, Journal of lipid research.

[23]  S. Naylor,et al.  Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[24]  R. Eddy,et al.  Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization. , 1985, Science.

[25]  T. Südhof,et al.  The LDL receptor gene: a mosaic of exons shared with different proteins. , 1985, Science.

[26]  D. Russell,et al.  The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA , 1984, Cell.

[27]  T. Carew,et al.  Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta. Predominance of intimal degradation. , 1984, Arteriosclerosis.

[28]  D. Vance,et al.  Isolation and analysis of lipoproteins secreted by rat liver hepatocytes. , 1984, Biochimica et biophysica acta.

[29]  R. Mahley,et al.  The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. , 1983, The Journal of biological chemistry.

[30]  R. Mahley,et al.  The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. , 1983, The Journal of biological chemistry.

[31]  Joseph L. Goldstein,et al.  Recycling receptors: The round-trip itinerary of migrant membrane proteins , 1983, Cell.

[32]  R. Mahley,et al.  Foam Cells in Explants of Atherosclerotic Rabbit Aortas Have Receptors for β‐Very Low Density Low Density Lipoproteins and Modified Low Density Lipoproteins , 1983, Arteriosclerosis.

[33]  Y. Marcel,et al.  Mapping of antigenic determinants of human apolipoprotein B using monoclonal antibodies against low density lipoproteins. , 1982, The Journal of biological chemistry.

[34]  M. Brown,et al.  Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia. , 1982, The Journal of biological chemistry.

[35]  C. Glueck,et al.  Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. , 1982, Journal of lipid research.

[36]  M. Lane,et al.  Association and assembly of triglyceride and phospholipid with glycosylated and unglycosylated apoproteins of very low density lipoprotein in the intact liver cell. , 1982, The Journal of biological chemistry.

[37]  J. Goldstein,et al.  Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia , 1982, Cell.

[38]  R. Mahley,et al.  Human apolipoprotein E. The complete amino acid sequence. , 1982, The Journal of biological chemistry.

[39]  M. Brown,et al.  Regulation of plasma cholesterol by lipoprotein receptors. , 1981, Science.

[40]  M. Malloy,et al.  Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein. , 1981, The Journal of clinical investigation.

[41]  T. Forte,et al.  Synthesis of two forms of apolipoprotein B by cultured rat hepatocytes. , 1981, Biochemical and biophysical research communications.

[42]  P. Weigel,et al.  Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps. , 1981, The Journal of biological chemistry.

[43]  C. Sparks,et al.  Analysis of lipoprotein apoproteins by SDS-gel filtration column chromatography. , 1981, Journal of lipid research.

[44]  R. Mahley,et al.  Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B. , 1980, The Journal of biological chemistry.

[45]  M. Brown,et al.  The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. , 1980, The Journal of biological chemistry.

[46]  K. V. Krishnaiah,et al.  Apolipoprotein B variant derived from rat intestine. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[47]  J. Kane,et al.  Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[48]  C. Glueck,et al.  Familial hyper‐alpha‐lipoproteinemia in 26 kindreds , 1980, Clinical genetics.

[49]  R. Mahley,et al.  Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors. , 1979, Biochimica et biophysica acta.

[50]  Richard G. W. Anderson,et al.  Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins , 1979, The Journal of cell biology.

[51]  H. G. Windmueller,et al.  Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. , 1979, The Journal of biological chemistry.

[52]  D. Steinberg,et al.  Metabolic studies in an unusual case of asymptomatic familial hypobetalipoproteinemia with hypolphalipoproteinemia and fasting chylomicronemia. , 1979, The Journal of clinical investigation.

[53]  Joseph L. Goldstein,et al.  Coated pits, coated vesicles, and receptor-mediated endocytosis , 1979, Nature.

[54]  R. Mahley,et al.  Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[55]  R. Lees,et al.  Immunofluorescence studies of apolipoprotein B in intestinal mucosa: Absence in abetalipoproteinemia , 1979 .

[56]  R. Mahley,et al.  Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. , 1978, The Journal of biological chemistry.

[57]  R. Mahley,et al.  Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. , 1977, The Journal of biological chemistry.

[58]  W. C. Breckenridge,et al.  Isolation and carbohydrate composition of glycopeptides of human apo low-density lipoprotein from normal and type II hyperlipoproteinemic subjects. , 1976, Canadian journal of biochemistry.

[59]  N. Swaminathan,et al.  The monosaccharide composition and sequence of the carbohydrate moiety of human serum low density lipoproteins. , 1976, Biochemistry.

[60]  C. Legum,et al.  Further observations on familial hypobetaliproteinaemia , 1976, Clinical genetics.

[61]  A. Beaudet,et al.  Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. , 1975, The Journal of biological chemistry.

[62]  J. Goldstein,et al.  Regulation of the activity of the low density lipoprotein receptor in human fibroblasts , 1975, Cell.

[63]  M. Brown,et al.  Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. , 1975, The Journal of clinical investigation.

[64]  M. Brown,et al.  Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. , 1974, The Journal of biological chemistry.

[65]  H. Thiede,et al.  Investigation of serum lipoproteins and apoproteins in abetalipoproteinaemia. , 1974, Clinical science and molecular medicine.

[66]  A. W. Kruski,et al.  A study of the abnormal lipoproteins in abetalipoproteinemia. , 1974, The Journal of clinical investigation.

[67]  A. Gotto,et al.  A molecular theory of lipid—protein interactions in the plasma lipoproteins , 1974, FEBS letters.

[68]  A. Khachadurian,et al.  A-beta-lipoproteinaemia and colour-blindness. , 1971, Archives of disease in childhood.

[69]  R. A. Cooper,et al.  The relationship between serum lipoproteins and red cell membranes in abetalipoproteinemia: deficiency of lecithin:cholesterol acyltransferase. , 1971, The Journal of laboratory and clinical medicine.

[70]  A. Gotto,et al.  On the protein defect in abetalipoproteinemia. , 1971, The New England journal of medicine.

[71]  J. Polonovski,et al.  [Asymptomatic familial hypolipoproteinemia involving mainly beta-lipoproteins revealed during the study of an isolated proteinuria]. , 1969, La Presse medicale.

[72]  A. Butkus,et al.  Familial hypo-β-lipoproteinemia: A genetic disorder of lipid metabolism with nervous system involvement , 1969 .

[73]  M. Schiffer,et al.  Use of helical wheels to represent the structures of proteins and to identify segments with helical potential. , 1967, Biophysical journal.

[74]  J. Lloyd,et al.  A-β-lipoproteinaemia , 1965 .

[75]  Charles R.scriver.  The Metabolic basis of inherited disease , 1989 .

[76]  D. Steinberg,et al.  Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[77]  D. Atkinson,et al.  Recombinant lipoproteins: implications for structure and assembly of native lipoproteins. , 1986, Annual review of biophysics and biophysical chemistry.

[78]  C. Disteche,et al.  Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[79]  M. Brown,et al.  Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. , 1983, Annual review of biochemistry.

[80]  N. Baker,et al.  Apolipoprotein B is structurally and metabolically heterogeneous in the rat. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[81]  S. Shapiro,et al.  Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins]. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[82]  W. Kannel,et al.  Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. , 1979, Annals of internal medicine.

[83]  M. Brown,et al.  Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[84]  M. Brown,et al.  The low-density lipoprotein pathway and its relation to atherosclerosis. , 1977, Annual review of biochemistry.