A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery.

[1]  S. Kates,et al.  Passive immunization with anti‐glucosaminidase monoclonal antibodies protects mice from implant‐associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters , 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[2]  S. Kates,et al.  A systematic review of animal models for Staphylococcus aureus osteomyelitis. , 2014, European cells & materials.

[3]  T. Randau,et al.  Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee , 2014, BMC Infectious Diseases.

[4]  A. Trampuz,et al.  High Activity of Fosfomycin and Rifampin against Methicillin-Resistant Staphylococcus aureus Biofilm In Vitro and in an Experimental Foreign-Body Infection Model , 2014, Antimicrobial Agents and Chemotherapy.

[5]  W. Ko,et al.  In Vitro Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus , 2013, Antimicrobial Agents and Chemotherapy.

[6]  Kevin P. Francis,et al.  Vancomycin-Rifampin Combination Therapy Has Enhanced Efficacy against an Experimental Staphylococcus aureus Prosthetic Joint Infection , 2013, Antimicrobial Agents and Chemotherapy.

[7]  M. Mariconda,et al.  Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty , 2013, BMC Musculoskeletal Disorders.

[8]  E. Schwarz,et al.  Anti-oxidation Treatment of Ultra High Molecular Weight Polyethylene Components to Decrease Periprosthetic Osteolysis: Evaluation of Osteolytic and Osteogenic Properties of Wear Debris Particles in a Murine Calvaria Model , 2013, Current Rheumatology Reports.

[9]  C. Murray,et al.  Earlier debridement and antibiotic administration decrease infection. , 2012, Journal of surgical orthopaedic advances.

[10]  K. Francis,et al.  Mouse model of chronic post‐arthroplasty infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long‐term study , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  Sabrina Shandley,et al.  Hyperbaric oxygen therapy in a mouse model of implant‐associated osteomyelitis , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  A. Mikos,et al.  Infection and tissue engineering in segmental bone defects--a mini review. , 2011, Current opinion in biotechnology.

[13]  D. Nicolau,et al.  Comparative Efficacies of Human Simulated Exposures of Telavancin and Vancomycin against Methicillin-Resistant Staphylococcus aureus with a Range of Vancomycin MICs in a Murine Pneumonia Model , 2010, Antimicrobial Agents and Chemotherapy.

[14]  Alessandro Bistolfi,et al.  In Vitro Comparison between Commercially and Manually Mixed Antibiotic-Loaded Bone Cements , 2010, Journal of applied biomaterials & biomechanics : JABB.

[15]  S. Guelcher,et al.  Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Todd D. Jaeblon,et al.  Polymethylmethacrylate: Properties and Contemporary Uses in Orthopaedics , 2010, The Journal of the American Academy of Orthopaedic Surgeons.

[17]  E. Schwarz,et al.  Effects of antiresorptive agents on osteomyelitis , 2010, Annals of the New York Academy of Sciences.

[18]  Stephan M Perren,et al.  Internal fixator for use in the mouse. , 2009, Injury.

[19]  J. Meehan,et al.  Local antibiotic therapy in osteomyelitis. , 2009, Seminars in plastic surgery.

[20]  E. Schwarz,et al.  Quantitative mouse model of implant‐associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[21]  R. Spencer,et al.  The role of polymethylmethacrylate bone cement in modern orthopaedic surgery. , 2007, The Journal of bone and joint surgery. British volume.

[22]  P. Stewart,et al.  Spatial Patterns of DNA Replication, Protein Synthesis, and Oxygen Concentration within Bacterial Biofilms Reveal Diverse Physiological States , 2007, Journal of bacteriology.

[23]  Guiqing Wang,et al.  Increased Vancomycin MICs for Staphylococcus aureus Clinical Isolates from a University Hospital during a 5-Year Period , 2006, Journal of Clinical Microbiology.

[24]  Hiroaki Matsuno,et al.  A new antibacterial carrier of hyaluronic acid gel , 2006, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[25]  Andreas F Widmer,et al.  Infections associated with orthopedic implants , 2006, Current opinion in infectious diseases.

[26]  S. Patil,et al.  Management of complex tibial and femoral nonunion using the Ilizarov technique, and its cost implications. , 2006, The Journal of bone and joint surgery. British volume.

[27]  C. Zalavras,et al.  Management of open fractures. , 2005, Infectious disease clinics of North America.

[28]  C. Bourgeault,et al.  Characterization of a chronic infection in an internally‐stabilized segmental defect in the rat femur , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[29]  M. Bosse,et al.  Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case report. , 2005, The Journal of bone and joint surgery. American volume.

[30]  D. Goldmann,et al.  Use of Confocal Microscopy To Analyze the Rate of Vancomycin Penetration through Staphylococcus aureus Biofilms , 2005, Antimicrobial Agents and Chemotherapy.

[31]  C. R. Arciola,et al.  Prevalence of cna, fnbA and fnbB adhesin genes among Staphylococcus aureus isolates from orthopedic infections associated to different types of implant. , 2005, FEMS microbiology letters.

[32]  W. Zimmerli,et al.  Prosthetic-joint infections. , 2004, The New England journal of medicine.

[33]  R. Darouiche.  Treatment of infections associated with surgical implants. , 2004, The New England journal of medicine.

[34]  S. Stapley,et al.  Spread of infection, in an animal model, after intramedullary nailing of an infected external fixator pin track , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[35]  D. Musher,et al.  Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria. , 1994, The Journal of infectious diseases.

[36]  L. Albrecht,et al.  Vancomycin Protein Binding in Patients with Infections Caused by Staphylococcus Aureus , 1991, DICP : the annals of pharmacotherapy.

[37]  D. T. Rock,et al.  Comparison of steady-state pharmacokinetics of two dosage regimens of vancomycin in normal volunteers , 1987, Antimicrobial Agents and Chemotherapy.

[38]  N. Beeching,et al.  Comparative in-vitro activity of antibiotics incorporated in acrylic bone cement. , 1986, The Journal of antimicrobial chemotherapy.

[39]  J. Calhoun,et al.  Adult osteomyelitis. , 2005, Infectious disease clinics of North America.