The platelet P2Y12 receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [3H]PSB-0413
暂无分享,去创建一个
C. Müller | C. Gachet | P. Ohlmann | M. Cattaneo | A. Lecchi | A. El-Tayeb
[1] P. Ohlmann,et al. β-arrestin-1 participates in thrombosis and regulates integrin αIIbβ3 signalling without affecting P2Y receptors desensitisation and function , 2012, Thrombosis and Haemostasis.
[2] S. Mundell,et al. An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets. , 2011, Blood.
[3] M. Cattaneo. Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate , 2011, Thrombosis and Haemostasis.
[4] M. Cattaneo. The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects. , 2011, Blood.
[5] M. Cattaneo. Molecular defects of the platelet P2 receptors , 2011, Purinergic Signalling.
[6] D. Summa,et al. The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions. , 2011, Pharmacological research.
[7] K. Jacobson,et al. Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500). , 2010, Pharmacological research.
[8] K. Jacobson,et al. P2Y nucleotide receptors: promise of therapeutic applications. , 2010, Drug discovery today.
[9] M. Cattaneo. New P2Y12 Inhibitors , 2010, Circulation.
[10] Meryem Köse,et al. High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. , 2009, Journal of medicinal chemistry.
[11] H. Katus,et al. Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene. , 2009, International journal of cardiology.
[12] M. Lohse,et al. Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with β-Arrestin-1 and -2* , 2008, Journal of Biological Chemistry.
[13] E. Schwedhelm,et al. P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease. , 2008, British journal of clinical pharmacology.
[14] C. Gachet. P2 receptors, platelet function and pharmacological implications , 2008, Thrombosis and Haemostasis.
[15] Geoffrey Burnstock,et al. Physiology and pathophysiology of purinergic neurotransmission. , 2007, Physiological reviews.
[16] S. Mundell,et al. Distinct Clathrin‐Coated Pits Sort Different G Protein‐Coupled Receptor Cargo , 2006, Traffic.
[17] K. Jacobson,et al. [32P]2‐iodo‐N6‐methyl‐(N)‐methanocarba‐2′‐deoxyadenosine‐3′,5′‐bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors , 2006, British journal of pharmacology.
[18] C. Gachet. Regulation of platelet functions by P2 receptors. , 2006, Annual review of pharmacology and toxicology.
[19] C. Müller,et al. Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors. , 2005, Bioorganic & medicinal chemistry letters.
[20] P. Fontana,et al. LETTER TO THE EDITOR: P2Y1 gene polymorphism and ADP‐induced platelet response , 2005, Journal of thrombosis and haemostasis : JTH.
[21] S. Mundell,et al. P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. , 2005, Blood.
[22] J. Herbert,et al. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. , 2005, Seminars in thrombosis and hemostasis.
[23] J. Galzi,et al. Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties? , 2005, Molecular Pharmacology.
[24] J. Cazenave,et al. Adenine triphosphate nucleotides are antagonists at the P2Y12 receptor , 2004, Journal of thrombosis and haemostasis : JTH.
[25] J. Cazenave,et al. Preparation of washed platelet suspensions from human and rodent blood. , 2004, Methods in molecular biology.
[26] P. Fontana,et al. P2Y12 H2 Haplotype Is Associated With Peripheral Arterial Disease: A Case-Control Study , 2003, Circulation.
[27] P. Fontana,et al. Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y12 Gene Sequence Variations in Healthy Subjects , 2003, Circulation.
[28] S. Kunapuli,et al. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. , 2003, Blood.
[29] J. Ware,et al. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[30] J. Bourguignon,et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. , 2001, European journal of pharmacology.
[31] J. Cazenave,et al. Desensitization of the Platelet Aggregation Response to ADP: Differential Down-regulation of the P2Y1 and P2cyc Receptors , 2000, Thrombosis and Haemostasis.
[32] P. Mannucci,et al. Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors , 1995, British journal of haematology.
[33] J. Herbert,et al. Binding of [3H]-2-methylthio ADP to rat platelets--effect of clopidogrel and ticlopidine. , 1994, The Journal of pharmacology and experimental therapeutics.
[34] G. Cristalli,et al. Identification of a receptor for ADP on blood platelets by photoaffinity labelling. , 1993, The Biochemical journal.
[35] P. Mannucci,et al. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. , 1992, Blood.
[36] Broekman Mj. Homogenization by nitrogen cavitation technique applied to platelet subcellular fractionation. , 1992 .
[37] D. Macfarlane. 2-Methylthioadenosine [beta-32P]diphosphate: synthesis and use as probe of platelet ADP receptors. , 1992, Methods in enzymology.
[38] G. Jamieson,et al. Identification of high-affinity (Kd 0.35 mumol/L) and low-affinity (Kd 7.9 mumol/L) platelet binding sites for ADP and competition by ADP analogues , 1988 .
[39] D. Macfarlane,et al. 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. , 1983, The Journal of clinical investigation.
[40] D. Macfarlane. The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway. , 1981, Molecular pharmacology.
[41] D Rodbard,et al. Ligand: a versatile computerized approach for characterization of ligand-binding systems. , 1980, Analytical biochemistry.
[42] J. Sixma,et al. Binding of adenosine diphosphate to human blood platelets and to isolated blood platelet membranes. , 1980, Biochimica et biophysica acta.
[43] A. J. Barber,et al. Isolation and characterization of plasma membranes from human blood platelets. , 1970, The Journal of biological chemistry.