Cancer's Fuel Choice: New Flavors for a Picky Eater.

[1]  P. Tamayo,et al.  Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. , 2015, Molecular cell.

[2]  D. Tuveson,et al.  The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 , 2015, Cell.

[3]  K. Ross,et al.  Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism , 2015, Nature.

[4]  Flore Kruiswijk,et al.  p53 in survival, death and metabolic health: a lifeguard with a licence to kill , 2015, Nature Reviews Molecular Cell Biology.

[5]  K. Brindle Imaging metabolism with hyperpolarized (13)C-labeled cell substrates. , 2015, Journal of the American Chemical Society.

[6]  D. Sabatini,et al.  SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance , 2015 .

[7]  P. Carmeliet,et al.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.

[8]  J. Mi,et al.  Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation. , 2015, Cell reports.

[9]  K. Brindle,et al.  Imaging tumor metabolism using positron emission tomography. , 2015, Cancer journal.

[10]  Fei Tang,et al.  An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. , 2015, Molecular cell.

[11]  E. Lengyel,et al.  Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment , 2015, Clinical Cancer Research.

[12]  A. Lane,et al.  Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. , 2015, The Journal of clinical investigation.

[13]  M. V. Vander Heiden,et al.  Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. , 2015, Cancer research.

[14]  T. Rohan,et al.  Breast cancer risk in metabolically healthy but overweight postmenopausal women. , 2015, Cancer research.

[15]  A. Harris,et al.  Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress , 2015, Cancer cell.

[16]  R. Deberardinis,et al.  Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases , 2014, Cell.

[17]  J. Rabinowitz,et al.  Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate , 2014, Cancer & metabolism.

[18]  R. Deberardinis,et al.  Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. , 2014, Molecular cell.

[19]  Jianxin Xie,et al.  A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. , 2014, Molecular cell.

[20]  Christian M. Metallo,et al.  Regulation of substrate utilization by the mitochondrial pyruvate carrier. , 2014, Molecular cell.

[21]  C. Allis,et al.  Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells , 2014, Nature.

[22]  E. Cheng,et al.  Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. , 2014, Molecular cell.

[23]  Zhandong Liu,et al.  Serine catabolism regulates mitochondrial redox control during hypoxia. , 2014, Cancer discovery.

[24]  John M. Asara,et al.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function , 2014, Nature.

[25]  Peter Kraft,et al.  Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development , 2014, Nature Medicine.

[26]  R. Weinberg,et al.  Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition , 2014, Cell.

[27]  Ruoning Wang,et al.  The Intercellular Metabolic Interplay between Tumor and Immune Cells , 2014, Front. Immunol..

[28]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[29]  R. Deberardinis,et al.  Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. , 2014, Cell reports.

[30]  D. Sabatini,et al.  Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides , 2014, Nature.

[31]  G. Daley,et al.  Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism , 2013, Cell.

[32]  Benjamin J. Raphael,et al.  Mutational landscape and significance across 12 major cancer types , 2013, Nature.

[33]  Ralph J DeBerardinis,et al.  Glutamine and cancer: cell biology, physiology, and clinical opportunities. , 2013, The Journal of clinical investigation.

[34]  J. Locasale Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.

[35]  E. White,et al.  Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids , 2013, Proceedings of the National Academy of Sciences.

[36]  Christian M. Metallo,et al.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells , 2013, Nature.

[37]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[38]  Karen Blyth,et al.  Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells , 2012, Nature.

[39]  Michael R. Green,et al.  Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. , 2012, Cancer cell.

[40]  H. Aburatani,et al.  Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. , 2012, Cancer cell.

[41]  J. Veuthey,et al.  Identification and Functional Expression of the Mitochondrial Pyruvate Carrier , 2012, Science.

[42]  Claire Redin,et al.  A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans , 2012, Science.

[43]  Gregory Stephanopoulos,et al.  Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis , 2012, BMC Proceedings.

[44]  Gerald C. Chu,et al.  Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.

[45]  G. Semenza,et al.  Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.

[46]  Jesse M. Platt,et al.  Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability , 2011, Proceedings of the National Academy of Sciences.

[47]  Christian M. Metallo,et al.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.

[48]  W. Marston Linehan,et al.  Reductive carboxylation supports growth in tumor cells with defective mitochondria , 2011, Nature.

[49]  Ayellet V. Segrè,et al.  The Lin28/let-7 Axis Regulates Glucose Metabolism , 2011, Cell.

[50]  Abhishek K. Jha,et al.  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer , 2011, Nature.

[51]  Marc Liesa,et al.  Pancreatic cancers require autophagy for tumor growth. , 2011, Genes & development.

[52]  T. P. Neufeld,et al.  TOR-dependent control of autophagy: biting the hand that feeds. , 2010, Current opinion in cell biology.

[53]  K. Kinzler,et al.  Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.

[54]  David Allard,et al.  Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.

[55]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[56]  M. McMahon,et al.  NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. , 2009, Trends in biochemical sciences.

[57]  Jennifer E. Van Eyk,et al.  c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2016 .

[58]  H. Christofk,et al.  Pyruvate kinase M2 is a phosphotyrosine-binding protein , 2008, Nature.

[59]  Kevin Bray,et al.  Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. , 2006, Cancer cell.

[60]  P. Vaupel,et al.  Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. , 2004, The oncologist.

[61]  Peter Vaupel,et al.  The role of hypoxia-induced factors in tumor progression. , 2004, The oncologist.

[62]  E. Eigenbrodt,et al.  Association of the src-gene product of rous sarcoma virus with a pyruvate-kinase inactivating factor , 1981, Molecular and Cellular Endocrinology.

[63]  M. Weiner,et al.  Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases. , 1979, Clinical chemistry.

[64]  P. Paul,et al.  Plasma acetate turnover and oxidation. , 1979, The Journal of clinical investigation.

[65]  B. Zhou,et al.  Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH 3 a Downregulation Graphical Abstract Highlights , 2017 .

[66]  C. Muñoz-Pinedo,et al.  Regulation of cancer metabolism by oncogenes and tumor suppressors. , 2014, Methods in enzymology.

[67]  Stefano Fanti,et al.  The clinical use of PET with (11)C-acetate. , 2012, American journal of nuclear medicine and molecular imaging.

[68]  이연수 Functional genomics reveal that the serine synthesis pathway is essential in breast cancer , 2011 .

[69]  W. Zong,et al.  Necrotic death as a cell fate. , 2006, Genes & development.

[70]  T. Schub Mouse Model of Pancreatic Cancer , 2004, Lab Animal.

[71]  J. Downward Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.