The mission of QuTech is to bring quantum technology to industry and society by translating fundamental scientific research into applied research. To this end we are developing Quantum Inspire (QI), a full-stack quantum computer prototype for future co-development and collaborative R&D in quantum computing. A prerelease of this prototype system is already offering the public cloud-based access to QuTech technologies such as a programmable quantum computer simulator (with up to 31 qubits) and tutorials and user background knowledge on quantum information science (www.quantum-inspire.com). Access to a programmable CMOS-compatible Silicon spin qubit-based quantum processor will be provided in the next deployment phase. The first generation of QI’s quantum processors consists of a double quantum dot hosted in an in-house grown SiGe/28Si/SiGe heterostructure, and defined with a single layer of Al gates. Here we give an overview of important aspects of the QI full-stack. We illustrate QI’s modular system architecture and we will touch on parts of the manufacturing and electrical characterization of its first generation two spin qubit quantum processor unit. We close with a section on QI’s qubit calibration framework. The definition of a single qubit Pauli X gate is chosen as concrete example of the matching of an experiment to a component of the circuit model for quantum computation.