Investigations of process parameters during dissolution studies of drug loaded 3D printed tablets

The present research paper attempts to study the effect of different process parameters on the dissolution rate during 3D printed tablets. Three-dimensional printing has the potential of serving tailored made tablets to cater personalized drug delivery systems. Fluorescein loaded PVA filaments through impregnation route was used to fabricate tablets based on Taguchi based design of experimentation using Fused Deposition Modelling (FDM). The effect of print speed, infill percentage and layer thickness were analyzed to study the effect on rate of dissolution. Infill percentage followed by print speed were found to be critical parameters affecting dissolution rate. The data analysis provided an insight into the study of interaction among different 3D printing parameters to develop an empirical relation for percentage release of the drug in human body.

[1]  A. Leardini,et al.  A methodology for the customization of hinged ankle-foot orthoses based on in vivo helical axis calculation with 3D printed rigid shells , 2020, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[2]  Pramod Kumar,et al.  Regulatory Updates and Analytical Methodologies for Nitrosamine Impurities Detection in Sartans, Ranitidine, Nizatidine, and Metformin along with Sample Preparation Techniques , 2020, Critical reviews in analytical chemistry.

[3]  Nasim Samiei,et al.  Recent trends on applications of 3D printing technology on the design and manufacture of pharmaceutical oral formulation: a mini review , 2020, Beni-Suef University Journal of Basic and Applied Sciences.

[4]  A. Healy,et al.  Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion Loading of Filaments for Fused Deposition Modelling of Solid Dosage Forms , 2020, Pharmaceutics.

[5]  M. Airaksinen,et al.  Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review , 2020, Pharmaceutics.

[6]  Jianping Zhou,et al.  Experimental study on preparation of coaxial drug-loaded tissue-engineered bone scaffold by 3D printing technology , 2019, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[7]  T. Tagami,et al.  Drug Incorporation into Polymer Filament Using Simple Soaking Method for Tablet Preparation Using Fused Deposition Modeling. , 2019, Biological & pharmaceutical bulletin.

[8]  Orestis L. Katsamenis,et al.  A 3D printed bilayer oral solid dosage form combining metformin for prolonged and glimepiride for immediate drug delivery , 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[9]  A. Kashani,et al.  Additive manufacturing (3D printing): A review of materials, methods, applications and challenges , 2018, Composites Part B: Engineering.

[10]  Changquan Calvin Sun,et al.  Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures , 2017, Pharmaceutical Research.

[11]  R. Kumar,et al.  Enhanced Brain Delivery of Dimethyl Fumarate Employing Tocopherol-Acetate-Based Nanolipidic Carriers: Evidence from Pharmacokinetic, Biodistribution, and Cellular Uptake Studies. , 2017, ACS chemical neuroscience.

[12]  M. A. Alhnan,et al.  A flexible-dose dispenser for immediate and extended release 3D printed tablets. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[13]  P. Langguth,et al.  Oral Solid Dosage Form Disintegration Testing - The Forgotten Test. , 2015, Journal of pharmaceutical sciences.

[14]  A. Basit,et al.  Fused-filament 3D printing (3DP) for fabrication of tablets. , 2014, International journal of pharmaceutics.

[15]  B. Ranjbar,et al.  Differential scanning calorimetry techniques: applications in biology and nanoscience. , 2010, Journal of biomolecular techniques : JBT.

[16]  C. Setty,et al.  RELEASE KINETICS – CONCEPTS AND APPLICATIONS , 2019, International Journal of Pharmacy Research & Technology.

[17]  A. Basit,et al.  3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[18]  B. Shastry,et al.  Pharmacogenetics and the concept of individualized medicine , 2006, The Pharmacogenomics Journal.