论文信息 - Retinal vascular caliber, diabetes, and retinopathy.

Retinal vascular caliber, diabetes, and retinopathy.

PURPOSE To assess the relationship of retinal vessel caliber with diabetes and diabetic retinopathy (DR). DESIGN Population-based cross-sectional analysis of the Blue Mountains Eye Study, Australia (n = 3,654, age >or=49 years). METHODS Diabetes was defined as physician-diagnosed or fasting blood glucose >or= 7.0 mmol/l; impaired fasting glucose as fasting glucose 6.1 to 6.9 mmol/l. DR was graded from retinal photographs. Retinal vessel caliber was measured from digitized images. RESULTS After controlling for age, gender, blood pressure, and other factors, mean retinal venular caliber was significantly wider in participants with moderate-severe nonproliferative DR (severe 262.7 microm; moderate 236.7 microm) than in nondiabetic participants (221.9 microm) or participants with diabetes but no DR (221.2 microm) (P < .0001). Mean retinal arteriolar caliber was significantly wider in participants with diabetes (193.5 microm) than in nondiabetic participants (190.2 microm) (P < .01). CONCLUSIONS Increasing severity of DR in persons with diabetes is associated with widening of retinal venular caliber.

[1] Paul Mitchell,et al. Reliability of computer‐assisted retinal vessel measurement in a population , 2002, Clinical & experimental ophthalmology.

[2] C. Gerhardinger,et al. Early cellular and molecular changes induced by diabetes in the retina , 2001, Diabetologia.

[3] E M Kohner,et al. Role of Blood Flow and Impaired Autoregulation in the Pathogenesis of Diabetic Retinopathy , 1995, Diabetes.

[4] Ronald Klein,et al. The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. , 2004, Archives of ophthalmology.

[5] Paul Latkany,et al. Ocular perfusion abnormalities in diabetes. , 2002, Acta ophthalmologica Scandinavica.

[6] T. Wong,et al. Retinal vascular caliber and risk of retinopathy in young patients with type 1 diabetes. , 2006, Ophthalmology.

[7] R. Klein,et al. Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. , 2003, Ophthalmology.