Changes in the human visual evoked potential caused by the anticholinergic agent hyoscine hydrobromide: comparison with results in Alzheimer's disease.

The anticholinergic drug hyoscine hydrobromide produced a slowing of the P2 and N3 components of the flash visual evoked potential (VEP) in young normals but did not affect the pattern reversal VEP. These results, which are similar to those found in Alzheimer's disease, could be explained by an underlying defect of the cholinergic system.

[1]  D. Drachman,et al.  Human memory and the cholinergic system. A relationship to aging? , 1974, Archives of neurology.

[2]  P. Davies,et al.  SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.

[3]  M. Rossor.  Neurotransmitters and CNS disease. Dementia. , 1982, Lancet.

[4]  V. Longo.  Behavioral and electroencephalographic effects of atropine and related compounds. , 1966, Pharmacological reviews.

[5]  H. Weingartner,et al.  Human serial learning: enhancement with arecholine and choline impairment with scopolamine. , 1978, Science.

[6]  G. Harding,et al.  VISUAL EVOKED POTENTIALS IN PRE-SENILE DEMENTIA , 1981 .

[7]  N. Sims,et al.  Acetylcholine synthesis and glucose oxidation are preserved in human brain obtained shortly after death , 1982, Neuroscience Letters.

[8]  Robert H. Perry,et al.  Neurotransmitter enzyme abnormalities in senile dementia Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue , 1977, Journal of the Neurological Sciences.

[9]  J. Coyle,et al.  Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.

[10]  M N Rossor,et al.  A post-mortem study of the cholinergic and GABA systems in senile dementia. , 1982, Brain : a journal of neurology.

[11]  Peter Davies,et al.  Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's-type dementia brains , 1977, Brain Research.

[12]  D M Bowen,et al.  Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. , 1976, Brain : a journal of neurology.

[13]  G. Blessed,et al.  NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA , 1977, The Lancet.

[14]  C. Shute,et al.  The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections. , 1967, Brain : a journal of neurology.

[15]  E K Perry,et al.  Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. , 1978, British medical journal.

[16]  A. Corona,et al.  Visual evoked potentials in aging of the brain. , 1982, Advances in neurology.

[17]  R. Spehlmann,et al.  Acetylcholine and the synaptic transmission of specific impulses to the visual cortex. , 1971, Brain : a journal of neurology.

[18]  J. Schwartzbaum,et al.  Effects of scopolamine upon behavioral reactivity and visually evoked potential to flashes in rats. , 1973, Journal of comparative and physiological psychology.

[19]  R. Spehlmann.  Acetylcholine and the synaptic transmission of non-specific impulses to the visual cortex. , 1971, Brain : a journal of neurology.

[20]  A. Ostfeld,et al.  Central nervous system effects of hyoscine in man. , 1962, The Journal of pharmacology and experimental therapeutics.

[21]  P. Davies.  Neurotransmitter-related enzymes in senile dementia of the alzheimer type , 1979, Brain Research.

[22]  Biochemical changes in Alzheimer's disease-senile dementia: neurotransmitters in senile dementia of the Alzheimer's type. , 1979, Research publications - Association for Research in Nervous and Mental Disease.

[23]  C E Wright,et al.  Presenile dementia--the use of the flash and pattern VEP in diagnosis. , 1984, Electroencephalography and clinical neurophysiology.

[24]  I. Grove-White,et al.  An analysis of the learning deficit following hyoscine administration to man , 1973, British journal of pharmacology.

[25]  D L Price,et al.  Alzheimer's disease: a disorder of cortical cholinergic innervation. , 1983, Science.

[26]  S. Bellur.  Alzheimer's Disease: Senile Dementia and Related Disorders , 1979 .

[27]  S. L. Visser,et al.  Visual evoked response in senile and presenile dementia. , 1976, Electroencephalography and clinical neurophysiology.