Diabetic Mice against Type 1 Diabetes Loss of Invariant Chain Protects Nonobese

Jenny M. Phillips, Anne Cooke and Elizabeth K. BikoffRichard J. Mellanby, Chad H. Koonce, Anthony Monti,http://www.jimmunol.org/content/177/11/7588J Immunol€2006; 177:7588-7598; ;Referenceshttp://www.jimmunol.org/content/177/11/7588.full#ref-list-1This article cites 78 articles, 35 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  A. Sant,et al.  Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules , 1996, The Journal of experimental medicine.

[2]  R. Zinkernagel,et al.  Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection. , 1997, Journal of immunology.

[3]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[4]  Chad H. Koonce,et al.  Dissecting MHC Class II Export, B Cell Maturation, and DM Stability Defects in Invariant Chain Mutant Mice1 , 2004, The Journal of Immunology.

[5]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[6]  R. Locksley,et al.  T Helper Subset Differentiation in the Absence of Invariant Chain , 1997, The Journal of experimental medicine.

[7]  H. Kikutani,et al.  The murine autoimmune diabetes model: NOD and related strains. , 1992, Advances in immunology.

[8]  C. Benoist,et al.  Back to central tolerance. , 2004, Immunity.

[9]  V. Apostolopoulos,et al.  The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder1 , 2000, The Journal of Immunology.

[10]  L. Karlsson,et al.  Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines , 1997, European journal of immunology.

[11]  K. Hirokawa,et al.  Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells , 1996, European journal of immunology.

[12]  Pau Serra,et al.  Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice , 2006, Nature Immunology.

[13]  D. Lo,et al.  Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development. , 1995, Immunity.

[14]  K. Wucherpfennig,et al.  pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH , 1999, The Journal of experimental medicine.

[15]  E. Unanue,et al.  The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. , 1996, Journal of immunology.

[16]  K. Yamamura,et al.  Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice , 1987, Nature.

[17]  L. Kjer-Nielsen,et al.  Prevention of diabetes in non-obese diabetic I-Ak transgenic mice , 1990, Nature.

[18]  R. Germain,et al.  Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression , 1993, The Journal of experimental medicine.

[19]  E. Unanue,et al.  Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. , 2000, Immunity.

[20]  R. Flavell,et al.  Preferential Th1 Immune Response in Invariant Chain-Deficient Mice1 , 2002, The Journal of Immunology.

[21]  R. Maehr,et al.  Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. , 2005, The Journal of clinical investigation.

[22]  C. Watts.  The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules , 2004, Nature Immunology.

[23]  A. Rudensky,et al.  Requirement for diverse, low-abundance peptides in positive selection of T cells. , 1999, Science.

[24]  C. Benoist,et al.  The influence of invariant chain on the positive selection of single T cell receptor specificities , 1995, European journal of immunology.

[25]  E. Kominami,et al.  The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway , 1998, European journal of immunology.

[26]  R. Germain,et al.  Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. , 1995, Immunity.

[27]  W. T. Schaiff,et al.  HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells , 1992, The Journal of experimental medicine.

[28]  D. Mathis,et al.  Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease , 1993, The Journal of experimental medicine.

[29]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[30]  E. Bikoff,et al.  BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge. , 1999, Journal of immunology.

[31]  Chad H. Koonce,et al.  Relaxed DM Requirements During Class II Peptide Loading and CD4+ T Cell Maturation in BALB/c Mice1 , 2001, The Journal of Immunology.

[32]  J. Sprent,et al.  A defect in central tolerance in NOD mice , 2001, Nature Immunology.

[33]  C. Benoist,et al.  Mice lacking the MHC class II-associated invariant chain , 1993, Cell.

[34]  C. Benoist,et al.  Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. , 1994, Science.

[35]  H. Ruley,et al.  H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection , 1996, Cell.

[36]  R. Flavell,et al.  Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms. , 1995, Immunity.

[37]  A. Rudensky,et al.  Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. , 2004, Immunity.

[38]  M. Kasai,et al.  Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells , 1992, The Journal of experimental medicine.

[39]  K. Garcia,et al.  A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. , 2000, Science.

[40]  C. Benoist,et al.  Defective central tolerance induction in NOD mice: genomics and genetics. , 2005, Immunity.

[41]  J. Bonifacino,et al.  Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. , 1994, The EMBO journal.

[42]  R. Tisch,et al.  An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[43]  F. Powrie,et al.  Regulatory T cells in the control of immune pathology , 2001, Nature Immunology.

[44]  C. Goodnow,et al.  Cellular and genetic mechanisms of self tolerance and autoimmunity , 2005, Nature.

[45]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[46]  I. Mellman,et al.  The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules , 1994, The Journal of experimental medicine.

[47]  P. Cresswell,et al.  A role for calnexin (IP90) in the assembly of class II MHC molecules. , 1994, The EMBO journal.

[48]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[49]  Clemencia Pinilla,et al.  Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice1 , 2001, The Journal of Immunology.

[50]  R. Schwartz,et al.  Natural regulatory T cells and self-tolerance , 2005, Nature Immunology.

[51]  P. Santamaria,et al.  A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity , 1997, The Journal of experimental medicine.

[52]  P. Cresswell.  Invariant Chain Structure and MHC Class II Function , 1996, Cell.

[53]  L. Adorini,et al.  Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development , 2003, The Journal of Immunology.

[54]  C. Goodnow,et al.  Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes , 2002, The Journal of experimental medicine.

[55]  D. Kioussis,et al.  Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain , 1990, Nature.

[56]  P. Ricciardi-Castagnoli,et al.  Dendritic cell maturation and antigen presentation in the absence of invariant chain. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[57]  T. Laufer,et al.  Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells , 2001, The Journal of experimental medicine.

[58]  P. A. Peterson,et al.  Antigen Presentation and T Cell Development in H2-M-Deficient Mice , 1996, Science.

[59]  E. Kominami,et al.  CLIP‐derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C‐terminal processing , 2000, European journal of immunology.

[60]  R. Zinkernagel,et al.  Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. , 1996, Cellular immunology.

[61]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[62]  C. Benoist,et al.  Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells , 2004, The Journal of experimental medicine.

[63]  Hiroaki Ito,et al.  Analysis of the Role of  Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response , 1998, The Journal of experimental medicine.

[64]  H. Ploegh,et al.  Proteolysis in MHC class II antigen presentation: who's in charge? , 2000, Immunity.

[65]  C. Benoist,et al.  Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway , 1996, Cell.

[66]  R. Lechler,et al.  In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Don C. Wiley,et al.  Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes , 2001, Nature Immunology.

[68]  James J Walters,et al.  Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity. , 2005, The Journal of clinical investigation.

[69]  J. Miller,et al.  Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[70]  J. Todd,et al.  Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. , 2001, Immunity.

[71]  A. Caton,et al.  The role of self-peptides in the development of CD4+ CD25+ regulatory T cells. , 2005, Current opinion in immunology.

[72]  L. Klein,et al.  Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self , 2001, Nature Immunology.

[73]  R. Busch,et al.  Developing and shedding inhibitions: how MHC class II molecules reach maturity. , 1996, Current opinion in immunology.

[74]  Christoph Peters,et al.  Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain , 2002, The Journal of experimental medicine.

[75]  A. Rudensky,et al.  Phenotype and function of CD4+ T cells in mice lacking invariant chain. , 1996, Journal of immunology.

[76]  H. Weiner,et al.  Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. , 2001, The Journal of clinical investigation.