Validation of expert-system image understanding in histopathology

The automated diagnostic assessment of tissue sections relies on knowledge-base-supported evaluation of tissue architecture and nuclear placement patterns. Given the multifaceted dependence structure of the relative placement of tissue components, it is not straightforward to ascertain whether the description used for the classification properly considers that dependence. Simulated imagery allows testing of the completeness of the descriptive information used in diagnostic assessment.<<ETX>>