Monitoring receptor signaling by intramolecular FRET.

[1]  Terry Kenakin,et al.  Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors. , 2007, Trends in pharmacological sciences.

[2]  M. Bouvier,et al.  The evasive nature of drug efficacy: implications for drug discovery. , 2007, Trends in pharmacological sciences.

[3]  S. Marullo,et al.  Resonance energy transfer approaches in molecular pharmacology and beyond. , 2007, Trends in pharmacological sciences.

[4]  Krzysztof Palczewski,et al.  Visual Rhodopsin Sees the Light: Structure and Mechanism of G Protein Signaling* , 2007, Journal of Biological Chemistry.

[5]  R. Lefkowitz,et al.  β-Arrestins and Cell Signaling , 2007 .

[6]  M. Lohse,et al.  Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. , 2007, The Journal of clinical investigation.

[7]  M. Lohse,et al.  Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching &bgr;1-Adrenergic but Locally Confined &bgr;2-Adrenergic Receptor–Mediated Signaling , 2006, Circulation research.

[8]  M. Lohse,et al.  GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling* , 2006, Journal of Biological Chemistry.

[9]  John A. Frangos,et al.  G protein-coupled receptors sense fluid shear stress in endothelial cells , 2006, Proceedings of the National Academy of Sciences.

[10]  R. Fischmeister,et al.  Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. , 2006, Circulation research.

[11]  M. Lohse,et al.  Simultaneous Optical Measurements of Cytosolic Ca2+ and cAMP in Single Cells , 2006, Science's STKE.

[12]  Carsten Hoffmann,et al.  Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer* , 2006, Journal of Biological Chemistry.

[13]  Michel Bouvier,et al.  Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes , 2006, Nature Structural &Molecular Biology.

[14]  Xavier Deupi,et al.  Coupling ligand structure to specific conformational switches in the β2-adrenoceptor , 2006, Nature chemical biology.

[15]  R. Tsien,et al.  The Fluorescent Toolbox for Assessing Protein Location and Function , 2006, Science.

[16]  M. Lohse,et al.  Monitoring of cAMP synthesis and degradation in living cells. , 2006, Physiology.

[17]  D. Cooper,et al.  Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP , 2006, Journal of Cell Science.

[18]  K. Eidne,et al.  Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET) , 2006, Nature Methods.

[19]  M. Lohse,et al.  Dynamics of receptor/G protein coupling in living cells , 2005, The EMBO journal.

[20]  M. Lohse,et al.  Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  S. Reiken,et al.  Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias , 2005, Cell.

[22]  M. Lohse,et al.  Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line*[boxs] , 2005, Journal of Biological Chemistry.

[23]  G. Schertler.  Structure of rhodopsin and the metarhodopsin I photointermediate. , 2005, Current opinion in structural biology.

[24]  Xavier Deupi,et al.  Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists* , 2005, Journal of Biological Chemistry.

[25]  M. Lohse,et al.  Molecular basis of inverse agonism in a G protein–coupled receptor , 2005, Nature chemical biology.

[26]  Pascale G. Charest,et al.  Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET , 2005, EMBO reports.

[27]  Martin J. Lohse,et al.  β-Arrestin Binding to the β2-Adrenergic Receptor Requires Both Receptor Phosphorylation and Receptor Activation* , 2005, Journal of Biological Chemistry.

[28]  Mark H Ellisman,et al.  A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells , 2005, Nature Methods.

[29]  Michel Bouvier,et al.  Real-time monitoring of receptor and G-protein interactions in living cells , 2005, Nature Methods.

[30]  Horst Wallrabe,et al.  Imaging protein molecules using FRET and FLIM microscopy. , 2005, Current opinion in biotechnology.

[31]  M. Lohse,et al.  Real-time Monitoring of the PDE2 Activity of Live Cells , 2005, Journal of Biological Chemistry.

[32]  Kees Jalink,et al.  Detecting cAMP‐induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator , 2004, EMBO reports.

[33]  Xiaodong Cheng,et al.  Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Lohse,et al.  Kinetics of G-protein-coupled receptor signalling and desensitization. , 2004, Biochemical Society transactions.

[35]  Martin J. Lohse,et al.  Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation*♦ , 2004, Journal of Biological Chemistry.

[36]  Martin J. Lohse,et al.  Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases , 2004, Circulation research.

[37]  Yang Xiang,et al.  Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. , 2004, The Journal of biological chemistry.

[38]  M. Lohse,et al.  Gi protein activation in intact cells involves subunit rearrangement rather than dissociation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  J. Bos.  Epac: a new cAMP target and new avenues in cAMP research , 2003, Nature Reviews Molecular Cell Biology.

[40]  M. Lohse,et al.  Measurement of the millisecond activation switch of G protein–coupled receptors in living cells , 2003, Nature Biotechnology.

[41]  Tullio Pozzan,et al.  Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes , 2002, Science.

[42]  A. Scheer,et al.  Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling. , 2001, The Journal of biological chemistry.

[43]  D. Cooper,et al.  A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[44]  Y. Liu,et al.  Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. , 2001, Biophysical journal.

[45]  K. Palczewski,et al.  Activation of rhodopsin: new insights from structural and biochemical studies. , 2001, Trends in biochemical sciences.

[46]  P. Devreotes,et al.  Receptor-Mediated Activation of Heterotrimeric G-Proteins in Living Cells , 2001, Science.

[47]  Roger Y. Tsien,et al.  Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Y. Umezawa,et al.  Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Ialpha and green fluorescent proteins. , 2000, Analytical chemistry.

[49]  S. Angers,et al.  Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[50]  U. Gether.  Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. , 2000, Endocrine reviews.

[51]  R. Tsien,et al.  green fluorescent protein , 2020, Catalysis from A to Z.

[52]  R. Tsien,et al.  Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin , 1997, Nature.

[53]  H. Khorana,et al.  Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin , 1996, Science.

[54]  O. Lichtarge,et al.  Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F , 1996, Nature.

[55]  Susan S. Taylor,et al.  Fluorescence ratio imaging of cyclic AMP in single cells , 1991, Nature.

[56]  Stepan Gambaryan,et al.  Fluorescent sensors for rapid monitoring of intracellular cGMP , 2005, Nature Methods.

[57]  Susan S. Taylor,et al.  A genetically encoded, fluorescent indicator for cyclic AMP in living cells , 1999, Nature Cell Biology.

[58]  J. Black,et al.  A personal view of pharmacology. , 1996, Annual review of pharmacology and toxicology.

[59]  A. Gilman,et al.  G proteins: transducers of receptor-generated signals. , 1987, Annual review of biochemistry.

[60]  L. Stryer.  Fluorescence energy transfer as a spectroscopic ruler. , 1978, Annual review of biochemistry.

[61]  Th. Förster.  Zwischenmolekulare Energiewanderung und Fluoreszenz , 1948 .