Viral Dynamics in HIV-1 Infection

We thank Alan Perelson for a critical reading of the manuscript. This work was supported by NIH grant AI28108.

[1]  K Inaba,et al.  Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. , 1992, Science.

[2]  S. Christmas,et al.  The role of mononuclear phagocytes in cardiac allograft rejection in the rat. III. The effect of cells extracted from rat cardiac allografts upon beating heart cell cultures. , 1982, Cellular immunology.

[3]  Jerome A. Zack,et al.  HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure , 1990, Cell.

[4]  Anthony S. Fauci,et al.  HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease , 1993, Nature.

[5]  C. Benson,et al.  Viral Dynamics in Human Immunodeficiency Virus Type 1 Infection , 1995 .

[6]  O. Bagasra,et al.  Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[7]  S. J. Clark,et al.  High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. , 1993, Science.

[8]  D. Richman,et al.  Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. , 1997, Science.

[9]  J. McCune,et al.  T cell turnover in HIV-1 disease. , 1997, Immunity.

[10]  R Brookmeyer,et al.  Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. , 1997, Science.

[11]  D. Ho,et al.  Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. , 1991, The New England journal of medicine.

[12]  D. Ho,et al.  HIV-1 dynamics in vivo. , 1995, Journal of biological regulators and homeostatic agents.

[13]  C H Fox,et al.  The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4. , 1989, Science.

[14]  D. Markovitz,et al.  The role of mononuclear phagocytes in HTLV-III/LAV infection. , 1986, Science.

[15]  J. Mcdougal,et al.  In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). , 1986, Journal of immunology.

[16]  Alan S. Perelson,et al.  Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue , 1996, Science.

[17]  E. Rosenberg,et al.  Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. , 1997, Science.

[18]  A. Collier,et al.  Plasma viremia in human immunodeficiency virus infection. , 1989, The New England journal of medicine.

[19]  R. Siliciano,et al.  Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection , 1997, Nature.

[20]  R. Rabin,et al.  Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. , 1995, The Journal of clinical investigation.

[21]  D. Richman,et al.  Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro , 1995, Journal of virology.

[22]  G. F. Burton,et al.  Follicular dendritic cells and human immunodeficiency virus infectivity , 1995, Nature.

[23]  A. McLean,et al.  In vivo estimates of division and death rates of human T lymphocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Justement,et al.  Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J. Coffin,et al.  HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy , 1995, Science.

[26]  D. Baltimore,et al.  Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: A molecular model for latency , 1990, Cell.

[27]  E A Emini,et al.  Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. , 1997, The New England journal of medicine.

[28]  Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. , 1990, Disease markers.

[29]  D. Littman.  Chemokine Receptors: Keys to AIDS Pathogenesis? , 1998, Cell.

[30]  P. S. Kim,et al.  HIV Entry and Its Inhibition , 1998, Cell.

[31]  A. Cann,et al.  HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation. , 1988, Science.

[32]  M P Dempsey,et al.  Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. , 1991, Science.

[33]  R P Johnson,et al.  Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. , 1998, Science.

[34]  Martin A. Nowak,et al.  Viral dynamics in human immunodeficiency virus type 1 infection , 1995, Nature.

[35]  Alan S. Perelson,et al.  Decay characteristics of HIV-1-infected compartments during combination therapy , 1997, Nature.

[36]  B. Cullen,et al.  Molecular basis of latency in pathogenic human viruses. , 1991, Science.

[37]  A. Perelson,et al.  Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection , 1995, Nature.

[38]  M. Hirsch,et al.  Infection of monocyte/macrophages by human T lymphotropic virus type III. , 1986, The Journal of clinical investigation.

[39]  M. Bukrinsky,et al.  Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[40]  D. Kraft,et al.  HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo. , 1995, Immunity.

[41]  N. Haigwood,et al.  Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis , 1992, The Journal of experimental medicine.

[42]  R. Furth.  Origin and turnover of monocytes and macrophages. , 1989 .

[43]  R. Steinman,et al.  Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid , 1996, Science.

[44]  A. Fauci,et al.  Lymphoid organs function as major reservoirs for human immunodeficiency virus. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Robert F. Siliciano,et al.  In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency , 1995, Nature Medicine.

[46]  M. Zupancic,et al.  Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. , 1997, Science.

[47]  M A Nowak,et al.  Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Eric N. Miller,et al.  HIV‐1 infection , 1990, Neurology.

[49]  J Leibowitch,et al.  Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. , 1997, Science.

[50]  A S Perelson,et al.  Dynamics of HIV-1 and CD4+ lymphocytes in vivo. , 1997, AIDS.

[51]  D. Richman,et al.  Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[52]  B. Cullen.  HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell , 1998, Cell.

[53]  D. Trono,et al.  Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency , 1992, Journal of virology.

[54]  T. Curiel,et al.  Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes , 1995, Nature Medicine.

[55]  R. Steinman,et al.  Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1 , 1994, Cell.

[56]  A. Perelson,et al.  HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time , 1996, Science.

[57]  D. Ho,et al.  Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. , 1989, The New England journal of medicine.

[58]  John W. Mellors,et al.  Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma , 1996, Science.

[59]  Ashley T. Haase,et al.  Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS , 1993, Nature.