Protective role of pigment epithelium‐derived factor (PEDF) in early phase of experimental diabetic retinopathy

Pigment epithelium‐derived factor (PEDF) is the most potent inhibitor of angiogenesis in the mammalian eye, thus suggesting that PEDF may protect against proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. We investigated here whether and how PEDF could prevent the development of diabetic retinopathy.

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