Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex.

A single injection of 5 or 10 microliters of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Recurrent focal epileptiform discharge caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on the neurochemical alterations induced by the principal metallic ions found in whole blood.

[1]  P. Schwartzkroin,et al.  Recordings from cortical epileptogenic foci induced by cobalt iontophoresis , 1977, Experimental Neurology.

[2]  A. Harris.  Cortical neuroglia in experimental epilepsy , 1975, Experimental Neurology.

[3]  N. H. Bass,et al.  Neuronal compartmentation of ionic cobalt in rat cerebral cortex during initiation of epileptiform activity , 1975, Experimental Neurology.

[4]  B. Jennett.  Epilepsy and acute traumatic intracranial haematoma. , 1975, Journal of neurology, neurosurgery, and psychiatry.

[5]  A. Seregi,et al.  Ascorbic acid-like effect of the soluble fraction of rat brain on adenosine triphosphatases and its relation to catecholamines and chelating agents. , 1974, Biochemical pharmacology.

[6]  P. Harrison.  Biochemistry of iron. , 1971, Clinical toxicology.

[7]  M. Toga,et al.  The Pathology of Post‐Traumatic Epilepsies , 1970, Epilepsia.

[8]  H. Payan.  Cerebral Lesions Produced in Rats by Various Implants; Epileptogenic Effect of Cobalt , 1967 .

[9]  G. Dawson,et al.  Cobalt applied to the sensorimotor area of the cortex cerebri of the rat , 1966, The Journal of physiology.

[10]  R. Dow,et al.  Cobalt-induced seizures in the cat. , 1965, Electroencephalography and clinical neurophysiology.

[11]  W. Caveness.  ONSET AND CESSATION OF FITS FOLLOWING CRANIOCEREBRAL TRAUMA. , 1963, Journal of neurosurgery.

[12]  R. Dow,et al.  The production of cobalt experimental epilepsy in the rat. , 1962, Electroencephalography and clinical neurophysiology.

[13]  H. Kaplan.  Management of Craniocerebral Trauma and its Relation to Subsequent Seizures , 1961, Epilepsia.

[14]  E. Richardson,et al.  Epilepsy in Cerebral Vascular Disease , 1954 .

[15]  C. Whitty,et al.  STUDIES IN TRAUMATIC EPILEPSY , 1952, Journal of neurology, neurosurgery, and psychiatry.

[16]  R. Gerard,et al.  Iron induced oxidations in brain and other tissues , 1941 .