Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.

We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.

[1]  Wei W. Yu,et al.  Inkjet printed surface enhanced Raman spectroscopy array on cellulose paper. , 2010, Analytical chemistry.

[2]  S. Aguirre,et al.  Paper-based bioassays using gold nanoparticle colorimetric probes. , 2008, Analytical chemistry.

[3]  R. V. Van Duyne,et al.  A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. , 2002, Journal of the American Chemical Society.

[4]  Carsten Sönnichsen,et al.  A molecular ruler based on plasmon coupling of single gold and silver nanoparticles , 2005, Nature Biotechnology.

[5]  David A. Schultz,et al.  Single-target molecule detection with nonbleaching multicolor optical immunolabels. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Sihai Chen,et al.  Plasmonic detection of a model analyte in serum by a gold nanorod sensor. , 2007, Analytical chemistry.

[7]  J. Hafner,et al.  A label-free immunoassay based upon localized surface plasmon resonance of gold nanorods. , 2008, ACS nano.

[8]  R. V. Van Duyne,et al.  A comparative analysis of localized and propagating surface plasmon resonance sensors: the binding of concanavalin a to a monosaccharide functionalized self-assembled monolayer. , 2004, Journal of the American Chemical Society.

[9]  Mikael Käll,et al.  Refractometric sensing using propagating versus localized surface plasmons: a direct comparison. , 2009, Nano letters.

[10]  M. El-Sayed,et al.  Dependence of the enhanced optical scattering efficiency relative to that of absorption for gold metal nanorods on aspect ratio, size, end-cap shape, and medium refractive index. , 2005, The journal of physical chemistry. B.

[11]  Jeffrey N. Anker,et al.  Biosensing with plasmonic nanosensors. , 2008, Nature materials.

[12]  Weian Zhao,et al.  Lab on paper. , 2008, Lab on a chip.

[13]  Jeffrey N. Anker,et al.  Gas sensing with high-resolution localized surface plasmon resonance spectroscopy. , 2010, Journal of the American Chemical Society.

[14]  S. Bajpai,et al.  Graft copolymerization onto cellulose-based filter paper and its further development as silver nanoparticles loaded antibacterial food-packaging material. , 2009, Colloids and surfaces. B, Biointerfaces.

[15]  Chad A Mirkin,et al.  Nanostructures in biodiagnostics. , 2005, Chemical reviews.

[16]  Milan Mrksich,et al.  A conformation- and ion-sensitive plasmonic biosensor. , 2011, Nano letters.

[17]  Adam Wax,et al.  Label-free plasmonic detection of biomolecular binding by a single gold nanorod. , 2008, Analytical chemistry.

[18]  R. V. Van Duyne,et al.  Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. , 2005, Journal of the American Chemical Society.

[19]  N. Jaffrezic‐Renault,et al.  Investigating antibody-antigen binding with atomic force microscopy , 2002 .

[20]  P. Pellegrino,et al.  Highly sensitive surface enhanced Raman scattering substrates based on filter paper loaded with plasmonic nanostructures. , 2011, Analytical chemistry.

[21]  Paul Mulvaney,et al.  Direct observation of chemical reactions on single gold nanocrystals using surface plasmon spectroscopy. , 2008, Nature nanotechnology.

[22]  Christian Hafner,et al.  In situ sensing of single binding events by localized surface plasmon resonance. , 2008, Nano letters.

[23]  L. Lechuga,et al.  LSPR-based nanobiosensors , 2009 .

[24]  E. Kharasch,et al.  Urinary biomarkers for the early diagnosis of kidney cancer. , 2010, Mayo Clinic proceedings.

[25]  Anand Gole,et al.  Azide-derivatized gold nanorods: functional materials for "click" chemistry. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[26]  Limei Tian,et al.  Paper-based SERS swab for rapid trace detection on real-world surfaces. , 2010, ACS applied materials & interfaces.

[27]  Peter Nordlander,et al.  A single molecule immunoassay by localized surface plasmon resonance , 2010, Nanotechnology.

[28]  Paul Mulvaney,et al.  Electrochemical charging of single gold nanorods. , 2009, Journal of the American Chemical Society.

[29]  G. Whitesides,et al.  Patterned paper as a platform for inexpensive, low-volume, portable bioassays. , 2007, Angewandte Chemie.

[30]  G. Spoto,et al.  COTTON TEXTILE FIBRES COATED BY AU/TIO2 FILMS: SYNTHESIS, CHARACTERIZATION AND SELF CLEANING PROPERTIES , 2008 .

[31]  Sarah Kim,et al.  Patterned arrays of au rings for localized surface plasmon resonance. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[32]  Whole serum BSA antibody screening using a label-free biophotonic nanoparticle array. , 2009, Analytical biochemistry.

[33]  S. Maier,et al.  Plasmonics: Localization and guiding of electromagnetic energy in metal/dielectric structures , 2005 .

[34]  Xu Li,et al.  A perspective on paper-based microfluidics: Current status and future trends. , 2012, Biomicrofluidics.

[35]  C. Mosher,et al.  Microminiaturized immunoassays using atomic force microscopy and compositionally patterned antigen arrays. , 1998, Analytical chemistry.

[36]  L. Chau,et al.  Sensing capability of the localized surface plasmon resonance of gold nanorods. , 2007, Biosensors & bioelectronics.

[37]  George C. Schatz,et al.  A nanoscale optical biosensor: The long range distance dependence of the localized surface plasmon resonance of noble metal nanoparticles , 2004 .

[38]  Claudio Parolo,et al.  Paper-based nanobiosensors for diagnostics. , 2013, Chemical Society reviews.

[39]  J. Hafner,et al.  Localized surface plasmon resonance sensors. , 2011, Chemical reviews.

[40]  Emanuel Carrilho,et al.  Paper-based ELISA. , 2010, Angewandte Chemie.

[41]  G. Whitesides,et al.  Diagnostics for the developing world: microfluidic paper-based analytical devices. , 2010, Analytical chemistry.

[42]  Serkan Bütün,et al.  Electron beam lithography designed silver nano-disks used as label free nano-biosensors based on localized surface plasmon resonance. , 2012, Optics express.

[43]  Adam Wax,et al.  Rational Selection of Gold Nanorod Geometry for Label-Free Plasmonic Biosensors , 2009, ACS nano.

[44]  Adam D. McFarland,et al.  A Nanoscale Optical Biosensor: Real-Time Immunoassay in Physiological Buffer Enabled by Improved Nanoparticle Adhesion , 2003 .

[45]  Wei Shen,et al.  Progress in patterned paper sizing for fabrication of paper-based microfluidic sensors , 2010 .