Miniature spectroscopic instrumentation: Applications to biology and chemistry

Spectroscopy is a fundamental analytical tool utilized throughout all of the sciences. For chemistry and biology alone, there are thousands of applications. In the past two decades there have been monumental advances in the miniaturization of components used in spectrophotometric systems. The key components include detector arrays, laser diodes, and fiber optics. Currently, there are numerous commercially available miniature spectrometer systems as well as discrete components that are used by researchers in designing their own systems. A comprehensive summary of current instrumentation available for the design and development of miniaturized spectroscopy applications is described, including detectors, wavelength discriminating components, light sources, and sampling assemblies. Recommendations are made for designing spectrometer systems for specific applications. Current literature is reviewed for chemical and biological applications specifically using miniaturized spectrometer systems with the focus being on ultraviolet-visible-near-infrared spectrometers. The applications include laboratory applications, environmental sensing, on-site industrial analyses, botany and ecology applications, and finally clinical and biochemical studies. Additionally, microspectrometers, two-dimensional arrays, and photonics crystals are discussed in regards to their future role in chemistry and biology applications.

[1]  J. Inoue,et al.  Photonic crystals versus diffraction gratings in Smith-Purcell radiation , 2002 .

[2]  C. Pickering,et al.  Modelling of high temperature optical constants and surface roughness evolution during MOVPE growth of GaN using in-situ spectral reflectometry , 2002 .

[3]  K. Yoshino,et al.  Tunable photonic band schemes of opals and inverse opals infiltrated with liquid crystals , 2002 .

[4]  Peter Beiersdorfer,et al.  Design and implementation of a high-resolution, high-efficiency optical spectrometer , 2002 .

[5]  N. H. Velthorst,et al.  Laser-based non-fluorescence detection techniques for liquid separation systems. , 2002, Journal of chromatography. A.

[6]  Adrian Ponce,et al.  An anthrax "smoke" detector , 2002 .

[7]  Susumu Noda,et al.  Recent progress of semiconductor photonic crystals , 2002, Proceedings of the 2nd IEEE Conference on Nanotechnology.

[8]  A. Cunningham,et al.  Assessment of a microscopic photobleaching technique for measuring the spectral absorption efficiency of individual phytoplankton cells , 2002 .

[9]  Alexei M. Zheltikov,et al.  Photonic crystals in nonlinear and ultrafast optics , 2002, Saratov Fall Meeting.

[10]  Edward R. Lyons,et al.  Fiber-optic-based optical trapping and detection for lab-on-a-chip (LOC) applications , 2002, SPIE BiOS.

[11]  Darwin R. Reyes,et al.  Micro total analysis systems. 2. Analytical standard operations and applications. , 2002, Analytical chemistry.

[12]  Darwin R. Reyes,et al.  Micro total analysis systems. 1. Introduction, theory, and technology. , 2002, Analytical chemistry.

[13]  M. Shur,et al.  Introduction to Solid-State Lighting , 2002 .

[14]  W. Richter,et al.  Real-time calibration of wafer temperature, growth rate and composition by optical in-situ techniques during AlxGa1−xAs growth in MOVPE , 2002 .

[15]  S. Saavedra,et al.  A simplified broadband coupling approach applied to chemically robust sol-gel, planar integrated optical waveguides. , 2002, Analytical chemistry.

[16]  P. Hietz,et al.  A new method to determine the oxygen concentration inside the sapwood of trees. , 2002, Journal of experimental botany.

[17]  Ö. Pekcan,et al.  UV-visible technique for studying powder coatings and their dissolution , 2001 .

[18]  B. Weckhuysen,et al.  Monitoring Chromia/Alumina Catalysts in Situ during Propane Dehydrogenation by Optical Fiber UV–Visible Diffuse Reflectance Spectroscopy , 2001 .

[19]  Lena Ohannesian,et al.  Handbook of Pharmaceutical Analysis , 2001 .

[20]  J. Farinas,et al.  A microfluidic device for measuring cellular membrane potential. , 2001, Analytical biochemistry.

[21]  F V Bright,et al.  Optical sensor array and integrated light source. , 2001, Analytical chemistry.

[22]  K. Cantrell.  The development and characterization of miniature spectrometers for measuring the redox status of environmental samples , 2001 .

[23]  P. Bernazzani,et al.  Modular Spectrometers in the Undergraduate Chemistry Laboratory , 2001 .

[24]  K. Roberts,et al.  High-performance liquid chromatography interfaced with fluorescence line-narrowing spectroscopy for on-line analysis. , 2001, Analytical Chemistry.

[25]  J B Shear,et al.  Development of multianalyte sensor arrays composed of chemically derivatized polymeric microspheres localized in micromachined cavities. , 2001, Journal of the American Chemical Society.

[26]  Robert McLaren,et al.  A Sensitive Small-Volume UV/Vis Flow Cell and Total Absorbance Detection System for Micro-HPLC , 2001 .

[27]  A. Chang,et al.  Enhanced detection of live bacteria using a dendrimer thin film in an optical biosensor. , 2001, Analytical chemistry.

[28]  B. Lipschultz,et al.  Applications of visible CCD cameras on the Alcator C-Mod tokamak , 2001 .

[29]  A. Cunningham,et al.  Ship-borne measurements of ocean colour: Development of a CCD-based reflectance radiometer and trials on a longitudinal transect of the Atlantic Ocean , 2001 .

[30]  Pablo J. Zarco-Tejada,et al.  Chlorophyll Fluorescence Effects on Vegetation Apparent Reflectance: I. Leaf-Level Measurements and Model Simulation , 2000 .

[31]  Wayne G. Sainty,et al.  Multiwavelength monitoring of thin film growth using a fiber spectrometer , 2000, SPIE Optics + Photonics.

[32]  Klavs F. Jensen,et al.  In-situ Reflectance Monitoring of GaSb Substrate Oxide Desorption , 2000 .

[33]  Yang,et al.  Multichannel mode-filtered light detection based on an optical fiber for small-volume chemical analysis , 2000, Analytical chemistry.

[34]  Sune Svanberg,et al.  Compact fiber-optic fluorosensor using a continuous-wave violet diode laser and an integrated spectrometer , 2000 .

[35]  Shannon E. Stitzel,et al.  Cross-reactive chemical sensor arrays. , 2000, Chemical reviews.

[36]  George P. Anderson,et al.  Automated Fiber Optic Biosensor for Multiplexed Immunoassays , 2000 .

[37]  O. Wolfbeis,et al.  Luminescence Lifetime Imaging of Oxygen, pH, and Carbon Dioxide Distribution Using Optical Sensors , 2000 .

[38]  José Higino Correia,et al.  High-selectivity single-chip spectrometer in silicon for operation in visible part of the spectrum , 2000 .

[39]  C. Mazel,et al.  Light absorption and utilization by colonies of the congeneric hermatypic corals Montastraea faveolata and Montastraea cavernosa , 2000 .

[40]  C. Wai,et al.  A high pressure fiber-optic reactor with charge-coupled device array ultraviolet-visible spectrometer for monitoring chemical processes in supercritical fluids , 1999 .

[41]  I. Robinson,et al.  The Southampton underwater multiparameter optical-fibre spectrometer system (SUMOSS) , 1999 .

[42]  Erik W. Anthon,et al.  Miniature spectrometer based on linear variable interference filters , 1999, Optics East.

[43]  Peter Dress,et al.  Linearity and effective optical pathlength of liquid waveguide capillary cells , 1999, Optics East.

[44]  Anand Asundi,et al.  Portable system approach of monitoring plant nutrient deficiency using fiber optic spectrophotometry , 1999, International Symposium on Photonics and Applications.

[45]  George R. Carruthers,et al.  Fast UV slitless spectrometer for meteor research , 1999, Optics & Photonics.

[46]  Wolfgang Budach,et al.  Planar Waveguides as High-Performance Sensing Platforms for Fluorescence-Based Multiplexed Oligonucleotide Hybridization Assays , 1999 .

[47]  Dean P. Neikirk,et al.  Single-analyte to multianalyte fluorescence sensors , 1999, Photonics West - Biomedical Optics.

[48]  B. McArthur,et al.  Penetration of ultraviolet radiation in the waters of the estuary and Gulf of St. Lawrence , 1999 .

[49]  Olivier Charon,et al.  Industrial combustion monitoring using optical sensors , 1999, Other Conferences.

[50]  O. Uy,et al.  Polymer-based lanthanide luminescent sensor for detection of the hydrolysis product of the nerve agent Soman in water. , 1999, Analytical chemistry.

[51]  Alois J. Adams,et al.  Spectral reflectance of rice seedlings , 1999, Other Conferences.

[52]  W. Breiland,et al.  In situ monitoring of GaSb, GaInAsSb, and AlGaAsSb 1 This work was sponsored by the Department of En , 1998 .

[53]  C. Wai,et al.  A SIMPLE HIGH PRESSURE FLOW CELL FOR ON-LINE ABSORPTION, RAMAN, AND TIME RESOLVED LASER INDUCED FLUORESCENCE SPECTROSCOPY IN SUPERCRITICAL FLUIDS , 1998 .

[54]  D. Dalgleish,et al.  Design of a Small Angle Spetrometer: Application to Milk Casein , 1998 .

[55]  Jerry Workman,et al.  Applied Spectroscopy: A Compact Reference for Practitioners , 1998 .

[56]  J. A. Howell,et al.  Ultraviolet and Absorption Light Spectrometry , 1998 .

[57]  Luis H. Garcia-Rubio,et al.  Multiangle-multiwavelength UV/visible spectroscopy for the characterization of the joint property distribution of whole blood and its components , 1998, Photonics West - Biomedical Optics.

[58]  David N. Sitter,et al.  A photospectrometer realized in a standard integrated circuit process , 1998 .

[59]  R. E. Fields,et al.  Solid-State Array Detectors for Analytical Spectrometry , 1997 .

[60]  Charles H. Mazel,et al.  Diver-operated instrument for in situ measurement of spectral fluorescence and reflectance of benthic marine organisms and substrates , 1997 .

[61]  Michael S. Patterson,et al.  Noninvasive in-vivo measurements of photosensitizer uptake using diffuse reflectance spectroscopy , 1997, Photonics West - Biomedical Optics.

[62]  Gregory T. A. Kovacs,et al.  Miniature spectrometers for biochemical analysis , 1997, Photonics West - Biomedical Optics.

[63]  Kenneth T. V. Grattan,et al.  Smart-sensor approach for a fibre-optic-based residual chlorine monitor , 1997 .

[64]  J. D. Vries.  Ozone Monitoring Instrument/Imaging Spectrometer , 1997 .

[65]  Stu Borman,et al.  Diverse Strategies Emerge For Diagnosing Alzheimer's Disease: Novel concepts under development include measurement of DNA damage and imaging of technetium complexes , 1996 .

[66]  Otto S. Wolfbeis,et al.  Capillary waveguide sensors , 1996 .

[67]  Haishan Zeng,et al.  Optical spectroscopy studies of diseased skin: preliminary results , 1996, Other Conferences.

[68]  K. Strong,et al.  Remote measurements of vertical profiles of atmospheric constituents with a UV-visible ranging spectrometer. , 1995, Applied optics.

[69]  Muamer Zukic,et al.  Miniaturized high-resolution NUV-VIS-NIR imaging spectrometer array for FAST SAT applications , 1994, Optics & Photonics.

[70]  B. Dierickx,et al.  Random addressable CMOS image sensor for industrial applications , 1994 .

[71]  Steven S Saavedra,et al.  Evanescent sensing in doped sol-gel glass films , 1994 .

[72]  J. Callis,et al.  Noninvasive monitoring of bulk polymerization using short-wavelength near-infrared spectroscopy , 1993 .

[73]  B. Mulloy,et al.  Microscopy, Optical Spectroscopy, and Macroscopic Techniques , 1993 .

[74]  Gregory C. Burke,et al.  Miniature optical-fiber-based spectrometer employing a compact tandem fiber probe , 1993, Other Conferences.

[75]  Roderic L. Jones,et al.  A novel ranging UV-visible spectrometer for remote sensing of the troposphere , 1993, Other Conferences.

[76]  M. Weling,et al.  Color detection using amorphous silicon Schottky photodiode , 1991 .

[77]  Norman C. Anheier,et al.  Planar waveguide spectrometer , 1990, Optics & Photonics.

[78]  N. Anheier,et al.  Miniaturized spectrometer employing planar waveguides and grating couplers for chemical analysis. , 1990, Applied optics.

[79]  A. Weeks,et al.  Introduction to laser diode-pumped solid state lasers , 2002 .

[80]  Bernard Valeur,et al.  New trends in fluorescence spectroscopy : applications to chemical and life sciences , 2001 .

[81]  G. Anderson,et al.  Multi-analyte interrogation using the fiber optic biosensor. , 2000, Biosensors & bioelectronics.

[82]  G. J. Dixon.  Spectrometers control manufacturing processes , 1998 .

[83]  O. Manuel Uy,et al.  Polymer Based Lanthanide Luminescent Sensors for the Detection of Nerve Agents , 1997 .

[84]  Leslie K. Moore,et al.  Miniature FlowProbTM chemical sensor , 1997 .

[85]  R. Clark,et al.  Biomedical applications of spectroscopy , 1996 .

[86]  M. Bonner Denton,et al.  Charge-Transfer Devices in Spectroscopy , 1994 .

[87]  Galen Wood Ewing,et al.  Analytical instrumentation handbook , 1990 .

[88]  A. E. Greenberg,et al.  Standard methods for the examination of water and wastewater : supplement to the sixteenth edition , 1988 .

[89]  C. L. Bashford,et al.  Spectrophotometry and spectrofluorimetry : a practical approach , 1987 .

[90]  H. Macleod,et al.  Thin-Film Optical Filters , 1969 .