Comparative numerical modeling of inhaled micron-sized particle deposition in human and rat nasal cavities

Abstract Micron-sized particle deposition in anatomically realistic models of a rat and human nasal cavity was numerically investigated. A steady laminar inhalation flow rate was applied and particles were released from the outside air. Particles showing equivalent total particle deposition fractions were classified into low, medium and high inertial particle. Typical particle sizes are 2.5, 9 and 20 μm for the human model and 1, 2 and 3 μm for the rat model, respectively. Using a surface-mapping technique the 3D nasal cavity surface was “unwrapped” into a 2D domain and the particle deposition locations were plotted for complete visual coverage of the domain surface. The total surface area comparison showed that the surface area of the human nasal model was about ten times the size of the rat model. In contrast, the regional surface area percentage analysis revealed the olfactory region of the rat model was significantly larger than all other regions making up ∼55.6% of the total surface area, while that of the human nasal model only occupying 10.5%. Flow pattern comparisons showed rapid airflow acceleration was found at the nasopharynx region and the nostril region for the human and rat model, respectively. For the human model, the main passage is the major deposition region for micro-particles. While for the rat model, it is the vestibule. Through comparing the regional deposition flux between human and rat models, this study can contribute towards better extrapolation approach of inhalation exposure data between inter-subject species.

[1]  Lung-Chi Chen,et al.  Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract , 2014, Inhalation toxicology.

[2]  Jiyuan Tu,et al.  Inhalability of micron particles through the nose and mouth , 2010, Inhalation toxicology.

[3]  Michael J. Oldham,et al.  Computational Fluid Dynamic Predictions and Experimental Results for Particle Deposition in an Airway Model , 2000 .

[4]  J. Tu,et al.  Detailed predictions of particle aspiration affected by respiratory inhalation and airflow , 2012 .

[5]  Hualiang Zhong,et al.  Modeling of release position and ventilation effects on olfactory aerosol drug delivery , 2013, Respiratory Physiology & Neurobiology.

[6]  S. Simpson,et al.  In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways , 1996 .

[7]  B. Asgharian,et al.  Deposition of fine and coarse aerosols in a rat nasal mold. , 2001, Inhalation toxicology.

[8]  Michelle Noga,et al.  Deposition of micrometer-sized aerosol particles in infant nasal airway replicas , 2008 .

[9]  Y. Cheng,et al.  Deposition of ultrafine aerosols in rat nasal molds. , 1990, Toxicology and applied pharmacology.

[10]  Ying Liu,et al.  Pulmonary responses to printer toner particles in mice after intratracheal instillation. , 2010, Toxicology letters.

[11]  Jeffry D Schroeter,et al.  Effects of Surface Smoothness on Inertial Particle Deposition in Human Nasal Models. , 2011, Journal of aerosol science.

[12]  R. C. Schroter,et al.  Mechanics of airflow in the human nasal airways , 2008, Respiratory Physiology & Neurobiology.

[13]  J. Kimbell,et al.  Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region , 2009, Inhalation toxicology.

[14]  J. Swenberg,et al.  Comparative morphometry of the nasal cavity in rats and mice. , 1982, Journal of anatomy.

[15]  Jiyuan Tu,et al.  Micron Particle Deposition in the Nasal Cavity Using the v2-f Model , 2011 .

[16]  Guilherme J M Garcia,et al.  Interindividual variability in nasal filtration as a function of nasal cavity geometry. , 2009, Journal of aerosol medicine and pulmonary drug delivery.

[17]  G. Ahmadi,et al.  Computational modelling of gas-particle flows with different particle morphology in the human nasal cavity , 2009 .

[18]  Cheng-Ping Chang,et al.  Development of a Taiwanese Head Model for Studying Occupational Particle Exposure , 2007, Inhalation toxicology.

[19]  R. H. Gray,et al.  Deposition and retention of inhaled aggregate 67Ga2O3 particles in beagle dogs, Fischer-344 rats, and CD-1 mice. , 1984, American Industrial Hygiene Association journal.

[20]  B. Li,et al.  Numerical Simulation of Airway Dimension Effects on Airflow Patterns and Odorant Deposition Patterns in the Rat Nasal Cavity , 2013, PloS one.

[21]  P. Högger,et al.  Development of an in vitro model to assess deposition of aerosol particles in a representative replica of the rat's respiratory tract. , 2012, Journal of aerosol medicine and pulmonary drug delivery.

[22]  J. Tu,et al.  A Numerical Study of Spray Particle Deposition in a Human Nasal Cavity , 2006 .

[23]  Y. Cheng,et al.  In vivo deposition of ultrafine aerosols in the nasal airway of the rat. , 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[24]  Jiyuan Tu,et al.  Numerical study of fibre deposition in a human nasal cavity , 2008 .

[25]  G. Ahmadi,et al.  CFD simulation of total and regional fiber deposition in human nasal cavities , 2014 .

[26]  J. Wen,et al.  Comparison of micron- and nanoparticle deposition patterns in a realistic human nasal cavity , 2009, Respiratory Physiology & Neurobiology.

[27]  Julia S. Kimbell,et al.  Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles , 2004 .

[28]  Jiyuan Tu,et al.  Numerical study of the effects of human body heat on particle transport and inhalation in indoor environment , 2013 .

[29]  Jiyuan Tu,et al.  Surface mapping for visualization of wall stresses during inhalation in a human nasal cavity , 2014, Respiratory Physiology & Neurobiology.

[30]  J. Tu,et al.  Source and trajectories of inhaled particles from a surrounding environment and its deposition in the respiratory airway , 2013, Inhalation toxicology.

[31]  W. Kreyling,et al.  Translocation of Inhaled Ultrafine Particles to the Brain , 2004, Inhalation toxicology.

[32]  Ming-Hsiu Chuang,et al.  In-Vivo Measurements of Micrometer-Sized Particle Deposition in the Nasal Cavities of Taiwanese Adults , 2012 .

[33]  Kai Zhao,et al.  Airflow and nanoparticle deposition in rat nose under various breathing and sniffing conditions: a computational evaluation of the unsteady effect. , 2010, Journal of aerosol science.

[34]  H. Clewell,et al.  Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. , 2008, Inhalation toxicology.

[35]  B. Asgharian,et al.  Inertial Particle Deposition in a Monkey Nasal Mold Compared with that in Human Nasal Replicas , 2005, Inhalation toxicology.

[36]  Goodarz Ahmadi,et al.  Numerical analysis of stochastic dispersion of micro-particles in turbulent flows in a realistic model of human nasal/upper airway , 2014 .

[37]  B. Wong,et al.  Experimental measurements and computational predictions of regional particle deposition in a sectional nasal model. , 2015, Journal of aerosol medicine and pulmonary drug delivery.

[38]  B. Asgharian,et al.  Computational fluid dynamics simulations of submicrometer and micrometer particle deposition in the nasal passages of a Sprague-Dawley rat , 2012 .

[39]  B. Asgharian,et al.  In vivo measurement of fine and coarse aerosol deposition in the nasal airways of female Long-Evans rats. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[40]  Jerry L. Campbell,et al.  Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages. , 2014, Toxicological sciences : an official journal of the Society of Toxicology.

[41]  Kevin R Minard,et al.  Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[42]  P. Dalton,et al.  Numerical modeling of turbulent and laminar airflow and odorant transport during sniffing in the human and rat nose. , 2006, Chemical senses.

[43]  J. Y. Tu,et al.  Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway , 2012, Comput. Biol. Medicine.

[44]  Michelle Noga,et al.  In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing , 2011 .