MTH1 is involved in the toxic and carcinogenic long-term effects induced by zinc oxide and cobalt nanoparticles

[1]  Wen-en Zhao,et al.  Potent and specific MTH1 inhibitors targeting gastric cancer , 2019, Cell Death & Disease.

[2]  Peter Wick,et al.  Transient DNA damage following exposure to gold nanoparticles. , 2018, Nanoscale.

[3]  M. K. Swamy,et al.  Potential applications of engineered nanoparticles in medicine and biology: an update , 2018, JBIC Journal of Biological Inorganic Chemistry.

[4]  K. Paknikar,et al.  Applications of cobalt ferrite nanoparticles in biomedical nanotechnology. , 2018, Nanomedicine.

[5]  Pradeep Kumar,et al.  Corrigendum: Application of Nanotechnology in Food Science: Perception and Overview , 2017, Front. Microbiol..

[6]  P. Mishra,et al.  Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications. , 2017, Drug discovery today.

[7]  Pradeep Kumar,et al.  Application of Nanotechnology in Food Science: Perception and Overview , 2017, Front. Microbiol..

[8]  R. Marcos,et al.  Long-term effects of silver nanoparticles in caco-2 cells , 2017, Nanotoxicology.

[9]  M. Akbari,et al.  Mitochondrial oxidative stress and dysfunction induced by single- and multiwall carbon nanotubes: A comparative study. , 2017, Journal of biomedical materials research. Part A.

[10]  Y. Nakabeppu,et al.  MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?☆ , 2017, Free radical biology & medicine.

[11]  Q. Sun,et al.  Expression and function of MutT homolog 1 in distinct subtypes of breast cancer , 2017, Oncology letters.

[12]  Jia Liu,et al.  Contribution of oxidative stress to TiO2 nanoparticle-induced toxicity. , 2016, Environmental toxicology and pharmacology.

[13]  Y. Kallberg,et al.  Validation and development of MTH1 inhibitors for treatment of cancer. , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[14]  C. Jiang,et al.  Reactive Oxygen Species Dictate the Apoptotic Response of Melanoma Cells to TH588. , 2016, The Journal of investigative dermatology.

[15]  Y. Liu,et al.  Cytotoxicity and genotoxicity in liver cells induced by cobalt nanoparticles and ions , 2016, Bone & joint research.

[16]  Mark D. Johnson,et al.  Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesis. , 2016, American journal of translational research.

[17]  Choon Nam Ong,et al.  Oxidative stress by inorganic nanoparticles. , 2016, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[18]  R. Marcos,et al.  Genotoxic and cell-transformation effects of multi-walled carbon nanotubes (MWCNT) following in vitro sub-chronic exposures. , 2016, Journal of hazardous materials.

[19]  Graeme Walker,et al.  Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. , 2016, Journal of medicinal chemistry.

[20]  F. Mseeh,et al.  Identification of potent and selective MTH1 inhibitors. , 2005, Bioorganic & medicinal chemistry letters.

[21]  R. Marcos,et al.  Acute and long-term in vitro effects of zinc oxide nanoparticles , 2016, Archives of Toxicology.

[22]  R. Marcos,et al.  Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency. , 2015, Mutation research.

[23]  David Rejeski,et al.  Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory , 2015, Beilstein journal of nanotechnology.

[24]  M. Wheatley,et al.  Acute exposure to ZnO nanoparticles induces autophagic immune cell death , 2015, Nanotoxicology.

[25]  D. Iannazzo,et al.  Toxicological assessment of multi-walled carbon nanotubes on A549 human lung epithelial cells. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[26]  Ricard Marcos,et al.  Long-term exposures to low doses of cobalt nanoparticles induce cell transformation enhanced by oxidative damage , 2015, Nanotoxicology.

[27]  R. Marcos,et al.  Genotoxic and cell-transforming effects of titanium dioxide nanoparticles. , 2015, Environmental research.

[28]  Richard Svensson,et al.  MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool , 2014, Nature.

[29]  D. Mateo,et al.  Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells , 2014, Toxicology mechanisms and methods.

[30]  Sabine U. Vorrink,et al.  Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models , 2014, Particle and Fibre Toxicology.

[31]  Ji-Eun Kim,et al.  Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.

[32]  A. Al-Khedhairy,et al.  Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells , 2013, International journal of nanomedicine.

[33]  Rongfa Guan,et al.  Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles , 2012, Nanoscale Research Letters.

[34]  Diana Anderson,et al.  Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2) , 2012, Apoptosis.

[35]  Y. Hwang,et al.  Photoluminescence characteristics of Cd1-xMnxTe single crystals grown by the vertical Bridgman method , 2012, Nanoscale Research Letters.

[36]  E Sabbioni,et al.  Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. , 2008, Mutagenesis.

[37]  T. Hirano.  Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis. , 2008, Journal of radiation research.

[38]  M. Ohno,et al.  Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs , 2008, The EMBO journal.

[39]  Laetitia Gonzalez,et al.  Genotoxicity of engineered nanomaterials: A critical review , 2008 .

[40]  K. Robbie,et al.  Nanomaterials and nanoparticles: Sources and toxicity , 2007, Biointerphases.

[41]  C. Bortner,et al.  Low level, long‐term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: Potential role in skin co‐carcinogenesis , 2005, International journal of cancer.

[42]  J. Chiu,et al.  Suppressed oxidant-induced apoptosis in cadmium adapted alveolar epithelial cells and its potential involvement in cadmium carcinogenesis. , 2000, Toxicology.