Transcriptional Reprogramming of Mature CD4+ T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes

[1]  B. Jabri,et al.  Intraepithelial lymphocytes in celiac disease immunopathology , 2012, Seminars in Immunopathology.

[2]  J. Kaye,et al.  TOX Is Required for Development of the CD4 T Cell Lineage Gene Program , 2011, The Journal of Immunology.

[3]  S. Swain,et al.  Cytotoxic CD4 T Cells in Antiviral Immunity , 2011, Journal of biomedicine & biotechnology.

[4]  Hilde Cheroutre,et al.  The light and dark sides of intestinal intraepithelial lymphocytes , 2011, Nature Reviews Immunology.

[5]  T. Waldmann,et al.  Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens , 2011, Nature.

[6]  W. Ellmeier,et al.  The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes , 2010, Nature Immunology.

[7]  Kyewon Park,et al.  The role of ThPOK in control of CD4/CD8 lineage commitment. , 2010, Annual review of immunology.

[8]  M. Kubo,et al.  Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells , 2010, Nature Immunology.

[9]  Dan R. Littman,et al.  Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria , 2009, Cell.

[10]  T. Strutt,et al.  Functionally Diverse Subsets in CD4 T Cell Responses Against Influenza , 2009, Journal of Clinical Immunology.

[11]  Lino Tessarollo,et al.  The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. , 2008, Immunity.

[12]  Hiroshi Kawamoto,et al.  Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate , 2008, Nature Immunology.

[13]  D. Green,et al.  Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. , 2008, Cell host & microbe.

[14]  H. Cheroutre,et al.  Doubting the TCR coreceptor function of CD8alphaalpha. , 2008, Immunity.

[15]  I. Taniuchi,et al.  Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development , 2008, Science.

[16]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[17]  B. Sullivan,et al.  Identification of Pre- and Postselection TCRαβ+ Intraepithelial Lymphocyte Precursors in the Thymus , 2006 .

[18]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[19]  M. Colonna,et al.  The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. , 2005, Blood.

[20]  M. Baseler,et al.  A Novel Flow Cytometric Assay for Evaluating Cell-Mediated Cytotoxicity , 2005, Journal of immunotherapy.

[21]  Xiaolong Liu,et al.  The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection , 2005, Nature Immunology.

[22]  Yi Zhang,et al.  The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment , 2005, Nature.

[23]  V. Appay The physiological role of cytotoxic CD4+ T‐cells: the holy grail? , 2004, Clinical and experimental immunology.

[24]  I. McInnes,et al.  Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. , 2004, Current opinion in pharmacology.

[25]  L. Chiriboga,et al.  Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. , 2004, Blood.

[26]  H. Cheroutre Starting at the beginning: new perspectives on the biology of mucosal T cells. , 2004, Annual review of immunology.

[27]  S. Pai,et al.  Critical roles for transcription factor GATA-3 in thymocyte development. , 2003, Immunity.

[28]  R. Koup,et al.  Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. , 2003, Journal of immunological methods.

[29]  Vahid Asnafi,et al.  Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. , 2003, Gastroenterology.

[30]  J. Alberola-Ila,et al.  GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. , 2003, Immunity.

[31]  Yoram Groner,et al.  Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  K. Kaukinen,et al.  Intraepithelial Lymphocytes in Celiac Disease , 2003, American Journal of Gastroenterology.

[33]  D. Littman,et al.  Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development , 2002, Cell.

[34]  Anthony D. Kelleher,et al.  Characterization of CD4+ CTLs Ex Vivo1 , 2002, The Journal of Immunology.

[35]  M. Bennett,et al.  2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes , 2001, Immunological reviews.

[36]  A. Alcamí,et al.  Viral mechanisms of immune evasion , 2000, Molecular Medicine Today.

[37]  N. Copeland,et al.  A molecular analysis of NKT cells: identification of a class‐I restricted T cell‐associated molecule (CRTAM) , 2000, Journal of leukocyte biology.

[38]  T. Matsuguchi,et al.  Interleukin-15 May Be Responsible for Early Activation of Intestinal Intraepithelial Lymphocytes after Oral Infection with Listeria monocytogenes in Rats , 1998, Infection and Immunity.

[39]  E. Ebert Interleukin 15 is a potent stimulant of intraepithelial lymphocytes. , 1998, Gastroenterology.

[40]  R. Hershberg,et al.  Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. , 1998, The Journal of clinical investigation.

[41]  K. Losos,et al.  An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. , 1997, Immunity.

[42]  P. Cresswell,et al.  Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs. , 1997, Journal of immunology.

[43]  J. D. Young,et al.  Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes. , 1996, Cellular immunology.

[44]  N. Ikewaki,et al.  Unique Properties of a Cytotoxic CD4+CD8+ Intraepithelial T‐Cell Line Established from the Mouse Intestinal Epithelium , 1994, Microbiology and immunology.

[45]  A. Nel,et al.  Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. , 1993, Journal of immunology.

[46]  P. Vassalli,et al.  Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules , 1991, The Journal of experimental medicine.

[47]  R. Winchester,et al.  Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells , 1979, The Journal of experimental medicine.

[48]  Deborah M. Brown,et al.  Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy. , 2010, Cellular immunology.

[49]  木村 元子 Regulation of Th2 cell differentiation by mel-18,a mammalian Polycomb group gene , 2002 .