Degranulation of paneth cells via toll-like receptor 9.

[1]  A. Ouellette,et al.  Paneth Cell Cryptdins Act in Vitro as Apical Paracrine Regulators of the Innate Inflammatory Response* , 2004, Journal of Biological Chemistry.

[2]  S. Akira,et al.  Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. , 2004, Gastroenterology.

[3]  R. Stradley,et al.  Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis , 2004, Histochemistry.

[4]  M. Mathan,et al.  The morphogenesis of the human Paneth cell , 2004, Histochemistry.

[5]  S. Poulsen,et al.  Immunohistochemical localization of epidermal growth factor in rat and man , 2004, Histochemistry.

[6]  Y. Satoh,et al.  Immunohistochemical observations of immunoglobulin A in the Paneth cells of germ-free and formerly-germ-free rats , 2004, Histochemistry.

[7]  R. Verger,et al.  Immunohistochemical localization of intestinal phospholipase A2 in rat paneth cells , 2004, Histochemistry.

[8]  Judy H. Cho,et al.  Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis , 2003, Gut.

[9]  A. Krieg,et al.  Oral Pretreatment of Mice with CpG DNA Reduces Susceptibility to Oral or Intraperitoneal Challenge with Virulent Listeria monocytogenes , 2003, Infection and Immunity.

[10]  D. McKay,et al.  Bacterial DNA evokes epithelial IL‐8 production by a MAPK‐dependent, NFκB‐independent pathway , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  S. Davies,et al.  Crohn's disease and the NOD2 gene: a role for paneth cells. , 2003, Gastroenterology.

[12]  T. Ganz.  Microbiology: Gut defence , 2003, Nature.

[13]  N. Salzman,et al.  Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin , 2003, Nature.

[14]  Jeffrey I. Gordon,et al.  Angiogenins: a new class of microbicidal proteins involved in innate immunity , 2003, Nature Immunology.

[15]  R. Vabulas,et al.  Bacterial CpG‐DNA and lipopolysaccharides activate Toll‐like receptors at distinct cellular compartments , 2002, European journal of immunology.

[16]  T. Ganz,et al.  Paneth cell trypsin is the processing enzyme for human defensin-5 , 2002, Nature Immunology.

[17]  K. Heeg,et al.  Immunostimulatory CpG-DNA Activates Murine Microglia1 , 2002, The Journal of Immunology.

[18]  T. Ganz,et al.  The multifaceted Paneth cell , 2002, Cellular and Molecular Life Sciences CMLS.

[19]  S. Akira,et al.  Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[21]  D. Podolsky,et al.  Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease , 2000, Infection and Immunity.

[22]  William C. Parks,et al.  Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria , 2000, Nature Immunology.

[23]  C. Potten,et al.  Gut instincts: thoughts on intestinal epithelial stem cells. , 2000, The Journal of clinical investigation.

[24]  C. Potten,et al.  Stem cells: the intestinal stem cell as a paradigm. , 2000, Carcinogenesis.

[25]  D. Podolsky,et al.  Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors1 , 2000, The Journal of Immunology.

[26]  M. Selsted,et al.  Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. , 2000, Nature immunology.

[27]  L. Matrisian,et al.  Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. , 1999, Science.

[28]  S. Wattler,et al.  Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs , 1999, Infection and Immunity.

[29]  G. Diamond,et al.  β-defensins: Endogenous antibiotics of the innate host defense response , 1998 .

[30]  J. Harty,et al.  CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. , 1998, Journal of immunology.

[31]  G. Hardiman,et al.  A family of human receptors structurally related to Drosophila Toll. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[32]  N. J. McNally,et al.  United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). , 1998, British Journal of Cancer.

[33]  D. Brewster,et al.  Trends in cancer incidence and mortality in Scotland: description and possible explanations. , 1998, British Journal of Cancer.

[34]  R. Lehrer,et al.  Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells , 1996, Infection and immunity.

[35]  D. Pisetsky.  Immune activation by bacterial DNA: a new genetic code. , 1996, Immunity.

[36]  A. Krieg,et al.  Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. , 1996, Journal of immunology.

[37]  D. Taupin,et al.  Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[38]  K. Anderson,et al.  A conserved signaling pathway: the Drosophila toll-dorsal pathway. , 1996, Annual review of cell and developmental biology.

[39]  M. Selsted,et al.  Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms , 1994, Infection and immunity.

[40]  D. Denhardt,et al.  Osteopontin: a protein with diverse functions , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  Douglas E. Jones,et al.  Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel , 1993, FEBS letters.

[42]  M. Mathan,et al.  An immunocytochemical ultrastructural study , 1987 .

[43]  G. Vantrappen,et al.  The Paneth cell: a source of intestinal lysozyme. , 1975, Gut.

[44]  G. Vantrappen,et al.  Localization of lysozyme activity in a Paneth cell granule fraction. , 1967, Biochimica et biophysica acta.