SP1/RNASEH2A accelerates the development of hepatocellular carcinoma by regulating EMT

[1]  Bin Chen,et al.  Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis , 2021, Tumori.

[2]  Jie Li,et al.  MicroRNA-125a-5p regulates liver cancer cell growth, migration and invasion and EMT by targeting HAX1 , 2020, International journal of molecular medicine.

[3]  Ligong Lu,et al.  Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis , 2020, Aging.

[4]  Shriti Singh,et al.  Challenges in liver cancer and possible treatment approaches. , 2020, Biochimica et biophysica acta. Reviews on cancer.

[5]  Yan Zhao,et al.  Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis , 2019, Journal of Hematology & Oncology.

[6]  E. Houghton,et al.  Aicardi-Goutieres Syndrome , 2019, Definitions.

[7]  L. Gediya,et al.  The retinamide VNLG‐152 inhibits f‐AR/AR‐V7 and MNK–eIF4E signaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth , 2018, The FEBS journal.

[8]  G. Nagaraju,et al.  Specificity protein 1: Its role in colorectal cancer progression and metastasis. , 2017, Critical reviews in oncology/hematology.

[9]  Shaolong Feng,et al.  Is the role of human RNase H2 restricted to its enzyme activity? , 2016, Progress in biophysics and molecular biology.

[10]  A. Nielsen,et al.  The role of epithelial to mesenchymal transition in resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. , 2016, Translational lung cancer research.

[11]  José Portugal,et al.  Sp1 transcription factor: A long-standing target in cancer chemotherapy. , 2015, Pharmacology & therapeutics.

[12]  Y. Crow,et al.  Aicardi–Goutières syndrome and the type I interferonopathies , 2015, Nature Reviews Immunology.

[13]  Ying Hu,et al.  A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes , 2014, PLoS genetics.

[14]  M. Zeng,et al.  Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma , 2014, Journal of Translational Medicine.

[15]  S. Safe,et al.  Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target , 2014, Expert opinion on therapeutic targets.

[16]  Wenjing Zhang,et al.  Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. , 2013, Oncology reports.

[17]  R. Basha,et al.  Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy. , 2012, Current medicinal chemistry.

[18]  Martin A. M. Reijns,et al.  The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease* , 2010, The Journal of Biological Chemistry.

[19]  M. Broggini,et al.  Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts. , 2010, Gynecologic oncology.

[20]  R. Huang,et al.  Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.

[21]  S. Chiou,et al.  Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma , 2009, Hepatology.

[22]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[23]  S. Henderson,et al.  Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets , 2009, Molecular Cancer Therapeutics.

[24]  J. Marrero,et al.  Diagnosis and treatment of hepatocellular carcinoma. , 2008, Gastroenterology.

[25]  R. Tjian,et al.  Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. , 1986, Science.

[26]  Zhen Liu,et al.  Identification of genes and candidate agents associated with pancreatic cancer , 2013, Tumor Biology.