Glycomic Analysis of Prostate Cancer 5f. Work Unit Number 7. Performing Organization Name(s) and Address(es) 8. Performing Organization Report Number Approved for Public Release; Distribution Unlimited Prostate Cancer, Glycomic Analysis, Health Disparity 16. Security Classification Of: 17. Limitatio

The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions; analysis of the IgA/IgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.