Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.
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[1] B. Hansen,et al. Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. , 1988, The Journal of clinical endocrinology and metabolism.
[2] F. Cordido,et al. Cholinergic receptor activation by pyridostigmine restores growth hormone (GH) responsiveness to GH-releasing hormone administration in obese subjects: evidence for hypothalamic somatostatinergic participation in the blunted GH release of obesity. , 1989, The Journal of clinical endocrinology and metabolism.
[3] J. Meites,et al. Growth hormone restores protein synthesis in skeletal muscle of old male rats. , 1985, Journal of gerontology.
[4] M. Vance,et al. Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. , 1989, The Journal of clinical endocrinology and metabolism.
[5] Ž. Reiner,et al. Effect of l-dopa on growth hormone, glucose, insulin, and cortisol response in obese subjects. , 2009, Experimental and clinical endocrinology.
[6] A. Rogol,et al. Impact of intensive venous sampling on characterization of pulsatile GH release. , 1987, The American journal of physiology.
[7] E. Arvat,et al. Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. , 1990, The Journal of clinical endocrinology and metabolism.
[8] H. Roffwarg,et al. Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. , 1972, The Journal of clinical endocrinology and metabolism.
[9] N. Ling,et al. Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. , 1984, The Journal of clinical endocrinology and metabolism.
[10] P. Björntorp,et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. , 1984, British medical journal.
[11] A. Rogol,et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. , 1987, The Journal of clinical endocrinology and metabolism.
[12] K. Alberti,et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. , 1988, The Journal of clinical investigation.
[13] J D Veldhuis,et al. Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass. , 1992, The Journal of clinical endocrinology and metabolism.
[14] L. Frohman,et al. Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. , 1984, The New England journal of medicine.
[15] M L Johnson,et al. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. , 1991, The Journal of clinical endocrinology and metabolism.
[16] J. Epelbaum,et al. Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion. , 1978, Endocrinology.
[17] P. Plotsky,et al. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. , 1985, Science.
[18] N. Mauras,et al. Increased hGH Production Rate after Low-Dose Estrogen Therapy in Prepubertal Girls with Turner's Syndrome , 1990, Pediatric Research.
[19] M. Shaw,et al. Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. , 1990, The Journal of clinical endocrinology and metabolism.
[20] P. Sönksen,et al. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. , 1989, The New England journal of medicine.
[21] Z. Laron,et al. Plasma Growth Hormone Response to Oral Clonidine as Compared to Insulin Hypoglycemia in Obese Children and Adolescents , 1984, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[22] A. Iranmanesh,et al. Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. , 1989, The Journal of clinical endocrinology and metabolism.
[23] N. Skakkebaek,et al. BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS , 1989, The Lancet.
[24] J. Beyer,et al. Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans , 1987, Journal of endocrinological investigation.
[25] L. Sjöström,et al. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. , 1983, The Journal of clinical investigation.
[26] D. Rudman,et al. Effects of human growth hormone in men over 60 years old. , 1990, The New England journal of medicine.
[27] D. Styne,et al. Changes in basal and stimulated growth hormone secretion in the aging rhesus monkey: a comparison of chair restraint and tether and vest sampling. , 1990, The Journal of clinical endocrinology and metabolism.
[28] A. Schally,et al. Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. , 1987, The Journal of clinical endocrinology and metabolism.
[29] A. Tofani,et al. Differential effects of feeding on the ultradian variation of the growth hormone (GH) response to GH-releasing hormone in normal subjects and patients with obesity and anorexia nervosa. , 1988, The Journal of clinical endocrinology and metabolism.
[30] W. Steffee,et al. Total human body protein synthesis in relation to protein requirements at various ages , 1975, Nature.
[31] M. Vitiello,et al. Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone. , 1985, Journal of gerontology.
[32] H. E. Palmer,et al. Effect of age on growth hormone secretion in man. , 1973, The Journal of clinical endocrinology and metabolism.
[33] N. Mauras,et al. Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. , 1987, The Journal of clinical endocrinology and metabolism.
[34] M. Shaw,et al. A rapid and simple assay for growth hormone-binding protein activity in human plasma. , 1988, Acta endocrinologica.
[35] R. Manna,et al. Effect of fenfluramine on growth hormone and prolactin secretion in obese subjects. , 1987, Hormone research.
[36] P. Gorden,et al. Abscence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly. , 1972, The Journal of clinical endocrinology and metabolism.
[37] S. Melmed,et al. Effects of Insulin on Rat Anterior Pituitary Cells: Inhibition of Growth Hormone Secretion and mRNA Levels , 1986, Diabetes.
[38] D. Cook,et al. THE RESPONSE OF OBESE SUBJECTS TO CONTINUOUS INFUSION OF HUMAN PANCREATIC GROWTH HORMONE‐RELEASING FACTOR 1–44 , 1985, Clinical endocrinology.
[39] A C Herington,et al. Identification and characterization of specific binding proteins for growth hormone in normal human sera. , 1986, The Journal of clinical investigation.
[40] A. Frantz,et al. Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1 , 1965 .
[41] S. Margolis,et al. Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity. , 1982, Metabolism: clinical and experimental.
[42] R. Urban,et al. Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals. , 1989, The American journal of physiology.
[43] R. Marcus,et al. Effects of short term administration of recombinant human growth hormone to elderly people. , 1990, The Journal of clinical endocrinology and metabolism.
[44] M L Johnson,et al. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[45] L. Agnati,et al. Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats , 1989, Peptides.
[46] K. Spik,et al. Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity. , 1989, Neuroendocrinology.
[47] R. McCARTER,et al. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. , 1985, The Journal of clinical endocrinology and metabolism.
[48] M. Kutner,et al. Impaired growth hormone secretion in the adult population: relation to age and adiposity. , 1981, The Journal of clinical investigation.