Lipase Catalysed Preparation of Optically Active α-Phenylethanol and the Related Substrates under Solvent free Condition †

Porcine pancreatic lipase (PPL) has been used as a chiral catalyst for the kinetic resolution of α-phenylethanol and the related derivatives (p-R'C6H4CH(OH)CH3, R'= CH3, MeO, Cl, Br) under solvent free conditions, with excellent enantioselectivities (ee's 81–98.5%).

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