Finite element analysis of electrical impedance myography in the rat hind limb

Electrical impedance myography (EIM) is a form of muscle assessment based on the surface application of electrical current and measurement of the resulting voltages over a muscle group of interest. In order to better understand the effect of pathological change in muscle, EIM has recently been applied to the rat. In this study, a finite element model of EIM is presented for the rat hind limb which incorporates the detailed anatomy of the leg based on computerized tomographic imaging and conductivity and permittivity values obtained from the rat gastrocnemius muscle. In addition, the angular anisotropy of the biceps femoris muscle has been included. The model successfully predicts the recorded surface impedances measured with EIM.

[1]  Keith D. Paulsen,et al.  Electrical Impedance Spectroscopy of the Human Prostate , 2007, IEEE Transactions on Biomedical Engineering.

[2]  Seward B Rutkove,et al.  Electrical impedance myography in the detection of radiculopathy , 2005, Muscle & nerve.

[3]  Robert A. Peura,et al.  Effects of sample geometry and electrode configuration on measured electrical resistivity of skeletal muscle , 2000, IEEE Transactions on Biomedical Engineering.

[4]  K. Foster,et al.  Dielectric properties of mammalian tissues from 0.1 to 100 MHz: a summary of recent data. , 1982, Physics in medicine and biology.

[5]  C. Gabriel Dielectric properties of biological tissue: Variation with age , 2005, Bioelectromagnetics.

[6]  Ronald Aaron,et al.  Assessing neuromuscular disease with multifrequency electrical impedance myography , 2006, Muscle & nerve.

[7]  R. Aaron,et al.  Electrical impedance myography in the bedside assessment of inflammatory myopathy , 2005, Neurology.

[8]  Seward B Rutkove,et al.  Localized bioimpedance analysis in the evaluation of neuromuscular disease , 2002, Muscle & nerve.

[9]  David A. Schoenfeld,et al.  Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials , 2007, Clinical Neurophysiology.

[10]  Seward B. Rutkove,et al.  Electrical impedance myography at 50kHz in the rat: Technique, reproducibility, and the effects of sciatic injury and recovery , 2009, Clinical Neurophysiology.

[11]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[12]  C A Shiffman,et al.  Resistivity and phase in localized BIA. , 1999, Physics in medicine and biology.