HNF-3β, C/EBPβ, and HNF-4 Act in Synergy to Enhance Transcription of the Human Apolipoprotein B Gene in Intestinal Cells

Recently, we identified a 315-bp intestinal enhancer (IE), localized over 55 kb upstream from the transcriptional start of the human apolipoprotein B (apoB) gene, that confers expression of human a...

[1]  M Sullivan,et al.  Identification and Characterization of a 315-Base Pair Enhancer, Located More than 55 Kilobases 5′ of the Apolipoprotein B Gene, That Confers Expression in the Intestine* , 2000, The Journal of Biological Chemistry.

[2]  M. Hadzopoulou-Cladaras,et al.  CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression* , 1999, The Journal of Biological Chemistry.

[3]  S. Young,et al.  Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes. An intestine-specific enhancer element is located between 54 and 62 kilobases 5' to the structural gene. , 1998, The Journal of biological chemistry.

[4]  S. Henning,et al.  Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha). , 1998, The Biochemical journal.

[5]  M. Carey,et al.  The Enhanceosome and Transcriptional Synergy , 1998, Cell.

[6]  S. Malik,et al.  Control of Apolipoprotein AI Gene Expression through Synergistic Interactions between Hepatocyte Nuclear Factors 3 and 4* , 1996, The Journal of Biological Chemistry.

[7]  S. Cereghini.  Liver‐enriched transcription factors and hepatocyte differentiation , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  B. Levy-Wilson.  Transcriptional control of the human apolipoprotein B gene in cell culture and in transgenic animals. , 1995, Progress in nucleic acid research and molecular biology.

[9]  J. Taylor,et al.  Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice , 1994, Molecular and cellular biology.

[10]  F. Sladek,et al.  Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription. , 1993, The Journal of biological chemistry.

[11]  B. Paulweber,et al.  Nuclease-hypersensitive sites define a region with enhancer activity in the third intron of the human apolipoprotein B gene. , 1992, The Journal of biological chemistry.

[12]  B. Levy-Wilson,et al.  Hepatocyte nuclear factor 1 and C/EBP are essential for the activity of the human apolipoprotein B gene second-intron enhancer , 1992, Molecular and cellular biology.

[13]  B. Paulweber,et al.  Similarities and differences in the function of regulatory elements at the 5' end of the human apolipoprotein B gene in cultured hepatoma (HepG2) and colon carcinoma (CaCo-2) cells. , 1991, The Journal of biological chemistry.

[14]  B. Paulweber,et al.  Identification of a negative regulatory region 5' of the human apolipoprotein B promoter. , 1991, The Journal of biological chemistry.

[15]  B. Mccarthy,et al.  Comparative analysis of sequences at the 5' end of the human and mouse apolipoprotein B genes. , 1991, DNA and cell biology.

[16]  B. Levy-Wilson,et al.  Characterization of tissue-specific enhancer elements in the second intron of the human apolipoprotein B gene. , 1991, The Journal of biological chemistry.

[17]  J. Darnell,et al.  Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. , 1990, Genes & development.

[18]  S. Young.  Recent Progress in Understanding Apolipoprotein B , 1990, Circulation.

[19]  K. Chien,et al.  Cardiovascular Molecular Biology: Introduction to the Series , 1989, Circulation.

[20]  R. Mahley,et al.  DNA sequence of the human apolipoprotein B gene. , 1987, DNA.

[21]  J. Gordon,et al.  Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J. Kane.  Apolipoprotein B: structural and metabolic heterogeneity. , 1983, Annual review of physiology.