Carotid atherosclerosis and arterial peripheral pulse wave velocity in cerebral thrombosis

Stiffening and thickening of the arterial walls are two important components of atherosclerosis. A better understanding of the relationship between stiffening and thickening of the large arteries might lead to optimal strategies for the prevention of cerebrovascular disease. However, there have been few investigations of the correlation between carotid artery wall thickening and arterial stiffness. In this study, we investigated the relationship between arterial stiffness (assessed by the ankle-brachial pulse wave velocity) and carotid plaque (detected by high-resolution real-time B-mode ultrasonography) in patients with cerebral thrombosis. The subjects were 109 patients with cerebral thrombosis aged 40-80 years. Fifty-six subjects had carotid plaque (27 had low-grade plaques (plaque score<7.0) and 29 had high-grade plaques (plaque score >or=7.0)) and 53 subjects did not have plaques. High pulse wave velocity was found to be significantly associated with existence of carotid plaque (p<0.001), but was not associated with the severity of the plaque (p=0.14) in multivariate logistic regression models. This study shows that the pulse wave velocity is associated with the existence of carotid atherosclerosis, but not with the severity of carotid atherosclerosis, in patients with cerebral thrombosis.

[1]  D. Sackett,et al.  Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. , 1991, The New England journal of medicine.

[2]  T. Ogihara,et al.  Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries. , 2000, Circulation.

[3]  M. Matsumoto,et al.  Ischemic stroke events and carotid atherosclerosis. Results of the Osaka Follow-up Study for Ultrasonographic Assessment of Carotid Atherosclerosis (the OSACA Study). , 1995, Stroke.

[4]  Ernesto L. Schiffrin,et al.  Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis , 2001, Hypertension.

[5]  W. Kannel,et al.  A general cardiovascular risk profile: the Framingham Study. , 1976, The American journal of cardiology.

[6]  P. Touboul,et al.  Carotid plaques, but not common carotid intima–media thickness, are independently associated with aortic stiffness , 2002, Journal of hypertension.

[7]  M. Iida,et al.  A Collaborative Study of Stroke Incidence in Japan: 1975–1979 , 1984, Stroke.

[8]  M. Iida,et al.  Usefulness of brachial-ankle pulse wave velocity measurement: correlation with abdominal aortic calcification. , 2003, Hypertension research : official journal of the Japanese Society of Hypertension.

[9]  K. D. Hopkins,et al.  Aortic distensibility in patients with cerebrovascular disease. , 1995, Clinical science.

[10]  G. Sicard.  MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–99%) or mild (0–29%) carotid stenosis: European Carotid Surgery Trialist' Collaborative Group. Lancet 1991;337:1235-43 , 1992 .

[11]  S. Laurent,et al.  Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients: A Longitudinal Study , 2002, Hypertension.

[12]  A. Buchan,et al.  *North American Symptomatic Carotid Endarterectomy Trial (NASCET) Steering Committee. Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis. , 1991 .

[13]  Masanori Munakata,et al.  Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients. , 2003, American journal of hypertension.

[14]  A. Simon,et al.  Heterogeneity of the atherosclerotic process in systemic hypertension poorly controlled by drug treatment. , 1987, The American journal of cardiology.

[15]  T. Shoji,et al.  Effect of Polymorphism of Apolipoprotein E and Angiotensin-Converting Enzyme Genes on Arterial Wall Thickness , 1997, Diabetes.

[16]  T. Shoji,et al.  Correlation between the intima-media thickness of the carotid artery and aortic pulse-wave velocity in patients with type 2 diabetes. Vessel wall properties in type 2 diabetes. , 1999, Diabetes care.

[17]  G. London,et al.  Arterial stiffening and vascular calcifications in end-stage renal disease. , 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[18]  J. Blacher,et al.  Impact of aortic stiffness on survival in end-stage renal disease. , 1999, Circulation.

[19]  C. Warlow,et al.  MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis , 1991, The Lancet.

[20]  A. Simon,et al.  Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women , 1993, European Journal of Epidemiology.

[21]  K Kimura,et al.  Ultrasonic evaluation of early carotid atherosclerosis. , 1990, Stroke.

[22]  W D Wagner,et al.  A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[23]  A. Hofman,et al.  Association Between Arterial Stiffness and Atherosclerosis: The Rotterdam Study , 2001, Stroke.

[24]  T. Kamada,et al.  Prevalence of Carotid Atherosclerosis in Diabetic Patients Ultrasound high-resolution B-mode imaging on carotid arteries , 1992, Diabetes Care.