Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
暂无分享,去创建一个
G. Halliday | O. Piguet | M. Kiernan | L. Ittner | Y. Ke | P. R. Asih | R. Chung | Julia van der Hoven | Annika van Hummel | Magdalena Przybyla | M. Morsch | Mian Bi | S. Ippati | Gabriella Chan | L. Suh | Wei S. Lee | Troy A Butler | T. Butler | Prita R Asih | Lisa S. Suh | W. S. Lee
[1] R. Tapia,et al. Excitatory and Inhibitory Neuronal Circuits in the Spinal Cord and Their Role in the Control of Motor Neuron Function and Degeneration. , 2018, ACS chemical neuroscience.
[2] H. Fuchs,et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss , 2017, Acta Neuropathologica.
[3] David A. Knowles,et al. Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice , 2017, Nature.
[4] A. Ittner. SITE-SPECIFIC PHOSPHORYLATION OF TAU INHIBITS AMYLOID-β TOXICITY IN ALZHEIMER’S MICE , 2016, Alzheimer's & Dementia.
[5] K. Young,et al. Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies , 2016, Cerebral cortex.
[6] G. Sobue,et al. Exosome secretion is a key pathway for clearance of pathological TDP-43. , 2016, Brain : a journal of neurology.
[7] M. Bellingham,et al. Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis , 2016, Scientific Reports.
[8] A. Bongers,et al. No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice , 2016, PloS one.
[9] J. Hodges,et al. The frontotemporal dementia-motor neuron disease continuum , 2016, The Lancet.
[10] M. Horne,et al. Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice. , 2016, Human molecular genetics.
[11] J. Trojanowski,et al. Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy , 2016, The Journal of Neuroscience.
[12] M. Hernandez,et al. Gait variability in people with neurological disorders: A systematic review and meta-analysis. , 2016, Human movement science.
[13] Hu Li,et al. The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity , 2016, Nature Medicine.
[14] G. Allali,et al. Gait Performance and Use of Mental Imagery as a Measure of Disease Progression in Amyotrophic Lateral Sclerosis , 2016, European Neurology.
[15] Qiang Ye,et al. A novel approach for analysis of altered gait variability in amyotrophic lateral sclerosis , 2015, Medical & Biological Engineering & Computing.
[16] J. Trojanowski,et al. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. , 2015, Human molecular genetics.
[17] J. Hodges,et al. Early‐onset axonal pathology in a novel P301S‐Tau transgenic mouse model of frontotemporal lobar degeneration , 2015, Neuropathology and applied neurobiology.
[18] G. Halliday,et al. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS , 2015, Acta Neuropathologica.
[19] J. Trojanowski,et al. Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43 , 2015, Acta Neuropathologica.
[20] A. Calas,et al. Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease , 2015, Metabolic Brain Disease.
[21] L. Ittner,et al. Genome Editing in Mice Using CRISPR/Cas9: Achievements and Prospects , 2015 .
[22] V. Kostic,et al. Gait in amyotrophic lateral sclerosis: Is gait pattern differently affected in spinal and bulbar onset of the disease during dual task walking? , 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.
[23] P. Callaerts,et al. TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis? , 2014, Trends in molecular medicine.
[24] L. Petrucelli,et al. Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling , 2014, PloS one.
[25] C. Jack,et al. Staging TDP-43 pathology in Alzheimer’s disease , 2014, Acta Neuropathologica.
[26] Inducible, tightly regulated and non-leaky neuronal gene expression in mice , 2014, Transgenic Research.
[27] Andrew L. Janke,et al. A segmentation protocol and MRI atlas of the C57BL/6J mouse neocortex , 2013, NeuroImage.
[28] E. Roberson. Mouse models of frontotemporal dementia , 2012, Annals of neurology.
[29] K. Toyka,et al. Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors , 2012, Experimental Neurology.
[30] L. Petrucelli,et al. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction , 2012, Acta Neuropathologica.
[31] L. Petrucelli,et al. Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice , 2011, Molecular Neurodegeneration.
[32] Bruce L. Miller,et al. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS , 2011, Neuron.
[33] David Heckerman,et al. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD , 2011, Neuron.
[34] Xavier Navarro,et al. Evolution of gait abnormalities in SOD1G93A transgenic mice , 2011, Brain Research.
[35] J. Trojanowski,et al. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. , 2011, The Journal of clinical investigation.
[36] S. Pereson,et al. TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration , 2010, Proceedings of the National Academy of Sciences.
[37] N. Cairns,et al. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration , 2009, Proceedings of the National Academy of Sciences.
[38] J. Trojanowski,et al. Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies* , 2009, Journal of Biological Chemistry.
[39] J. Trojanowski,et al. Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation* , 2008, Journal of Biological Chemistry.
[40] B. McConkey,et al. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis , 2008, Nature Genetics.
[41] Murray Grossman,et al. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis , 2008, The Lancet Neurology.
[42] Bruce L. Miller,et al. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis , 2006, Science.
[43] Francisco E. Baralle,et al. Characterization and Functional Implications of the RNA Binding Properties of Nuclear Factor TDP-43, a Novel Splicing Regulator ofCFTR Exon 9* , 2001, The Journal of Biological Chemistry.