Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.
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M. Koyama | N. Seki | K. Sugahara | A. Fukunari | H. Kataoka | T. Sugita | K. Chiba | K. Shimano
[1] N. Seki,et al. Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. , 2010, International immunology.
[2] K. Chiba. Sphingosine 1-phosphate receptor type 1 as a novel target for the therapy of autoimmune diseases , 2010 .
[3] Ludwig Kappos,et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. , 2010, The New England journal of medicine.
[4] Ludwig Kappos,et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. , 2010, The New England journal of medicine.
[5] X. Montalban,et al. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results , 2010, Multiple sclerosis.
[6] V. Brinkmann. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system , 2009, British journal of pharmacology.
[7] B. Segal,et al. IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition , 2008, The Journal of experimental medicine.
[8] J. Goverman,et al. Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells , 2008, Nature Medicine.
[9] J. Cyster,et al. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. , 2008, Immunity.
[10] E. Persohn,et al. Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis , 2007, Journal of Pharmacology and Experimental Therapeutics.
[11] C. A. Foster,et al. FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis , 2007, Brain Research Bulletin.
[12] H. Matsuyuki,et al. Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3 , 2007, The Journal of Immunology.
[13] Ludwig Kappos,et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. , 2006, The New England journal of medicine.
[14] S. Nakae,et al. IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis1 , 2006, The Journal of Immunology.
[15] H. Weiner,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.
[16] H. Matsuyuki,et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. , 2006, Cellular & molecular immunology.
[17] M. Koyama,et al. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. , 2005, Cellular & molecular immunology.
[18] K. Chiba. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. , 2005, Pharmacology & therapeutics.
[19] K. Adachi,et al. Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. , 2005, Bioorganic & medicinal chemistry.
[20] R. Proia,et al. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit , 2005, The Journal of experimental medicine.
[21] T. Mcclanahan,et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation , 2005, The Journal of experimental medicine.
[22] J. Chun,et al. Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice , 2004, Journal of Neuroimmunology.
[23] R. Proia,et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 , 2004, Nature.
[24] H. Amemiya,et al. Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment , 2003, Journal of Pharmacology and Experimental Therapeutics.
[25] Michael D. Davis,et al. The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors* , 2002, The Journal of Biological Chemistry.
[26] H. Rosen,et al. Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists , 2002, Science.
[27] T. Fujita,et al. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720 , 1995 .
[28] V. Kuchroo,et al. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. , 1993, Journal of immunology.
[29] L. Steinman. Mixed results with modulation of TH-17 cells in human autoimmune diseases , 2010, Nature Immunology.
[30] J. Cyster,et al. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. , 2005, Annual review of immunology.
[31] H. McFarland,et al. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. , 1995, Critical reviews in clinical laboratory sciences.
[32] D. McFarlin,et al. Immunological aspects of demyelinating diseases. , 1992, Annual review of immunology.