The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
暂无分享,去创建一个
R. Palmqvist | A. Öberg | M. L. Wikberg | S. Edin | B. Jonsson | R Palmqvist | Å Öberg | V Eklöf | M L Wikberg | S Edin | A M Dahlin | B-A Jonsson | J Rutegård | J. Rutegård | V. Eklöf | A. Dahlin | Maria L. Wikberg | Björn-Anders Jonsson
[1] P. Kuppen,et al. PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis , 2011, Cellular Oncology.
[2] R. Ward,et al. Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[3] A. Jemal,et al. Cancer Statistics, 2008 , 2008, CA: a cancer journal for clinicians.
[4] E. Riboli,et al. Low folate levels may protect against colorectal cancer , 2006, Gut.
[5] M. Loda,et al. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. , 2007, The Journal of molecular diagnostics : JMD.
[6] P. Catalano,et al. Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy , 2007, Clinical Cancer Research.
[7] P. Laird,et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer , 2006, Nature Genetics.
[8] D. Spiegelman,et al. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. , 2009, Gastroenterology.
[9] P. Laurent-Puig,et al. Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. , 2008, Cancer research.
[10] M. Kohonen-Corish,et al. Low microsatellite instability is associated with poor prognosis in stage C colon cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] B. Iacopetta,et al. CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[12] J. Jakić-Razumović,et al. Mutation pattern of KRAS and BRAF oncogenes in colorectal cancer patients. , 2011, Neoplasma.
[13] B. Leggett,et al. Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma , 2004, Gut.
[14] Carl W. Miller,et al. Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. , 2007, Leukemia research.
[15] W. Grady. Genomic instability and colon cancer , 2004, Cancer and Metastasis Reviews.
[16] Peter Kraft,et al. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] A. Bardelli,et al. Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer , 2009, Journal of the National Cancer Institute.
[18] S. Andreola,et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[19] S. Bull,et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. , 2000, The New England journal of medicine.
[20] Daniel J. Freeman,et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] Y. Samuels,et al. Oncogenic PI3K and its role in cancer , 2006, Current opinion in oncology.
[22] S. Kato,et al. Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer , 2013, International Journal of Clinical Oncology.
[23] S. Benlloch,et al. Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. , 2006, The Journal of molecular diagnostics : JMD.
[24] J. Herman,et al. Association between CpG island methylation and microsatellite instability in colorectal cancer. , 1997, Cancer research.
[25] Nobuo Ochi,et al. Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival , 2008, BMC gastroenterology.
[26] R. Palmqvist,et al. The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status , 2010, Clinical Cancer Research.
[27] H. Stenmark,et al. Aberrant receptor signaling and trafficking as mechanisms in oncogenesis. , 2007, Critical reviews in oncogenesis.
[28] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.
[29] Xin Wang,et al. KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. , 2011, Oncology reports.
[30] A. Lièvre,et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. , 2006, Cancer research.
[31] Reiko Nishihara,et al. Imaging , Diagnosis , Prognosis Prognostic Role of PIK 3 CA Mutation in Colorectal Cancer : Cohort Study and Literature Review , 2012 .
[32] Sabine Tejpar,et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. , 2010, The Lancet. Oncology.
[33] Tae Won Kim,et al. KRAS mutation status and clinical outcome of preoperative chemoradiation with cetuximab in locally advanced rectal cancer: a pooled analysis of 2 phase II trials. , 2013, International journal of radiation oncology, biology, physics.
[34] A. Bardelli,et al. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[35] D. Spiegelman,et al. Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803 , 2011, Clinical Cancer Research.
[36] L. Griškevičius,et al. KRas and BRaf mutational status analysis from formalin-fixed, paraffin-embedded tissues using multiplex polymerase chain reaction-based assay. , 2010, Archives of pathology & laboratory medicine.
[37] Hua-Chuan Zheng,et al. PTEN expression and mutation in colorectal carcinomas. , 2009, Oncology reports.
[38] F. Cavalli,et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients , 2007, British Journal of Cancer.
[39] D. Choi,et al. Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma , 2010, Histopathology.
[40] R. Houlston,et al. Systematic review of microsatellite instability and colorectal cancer prognosis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[41] Elena A. Manilich,et al. BRAF Mutations in Colorectal Cancer Are Associated With Distinct Clinical Characteristics and Worse Prognosis , 2012, Diseases of the colon and rectum.
[42] I. Nagtegaal,et al. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. , 2010, European journal of cancer.
[43] L. Mazzucchelli,et al. Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer , 2009, PloS one.
[44] R. Wolff,et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. , 2005, Gastroenterology.
[45] J. E. Boers,et al. Concordance in KRAS and BRAF mutations in endoscopic biopsy samples and resection specimens of colorectal adenocarcinoma. , 2012, European journal of cancer.
[46] L. Weinehall,et al. Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort- evaluation of risk factors and their interactions , 2003, Scandinavian journal of public health. Supplement.