Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa

objective In animals, somatostatin (SRIH) and growth hormone (GH)‐releasing hormone (GHRH) increase feeding via a common neural mechanism. Furthermore, SRIH counteracts the suppressive action of corticotrophin‐releasing hormone (CRH) on food intake. Hypothetically, SRIH could be involved in the central feeding mechanism in anorexia nervosa (AN). Peripheral administration of pyridostigmine (PD) minimizes the release of hypothalamic SRIH.

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