Clinical Profile and Evaluation of Outcomes of Symptomatic Gallstone Disease in the Senior Citizen Population

Background There is a heavy burden of gallstone disease on the world’s population. The incidence and severity of symptomatic cholelithiasis increase with age. There is often a delay in presentation, leading to complicated disease, diagnostic delay, and increased morbidity. There is a paucity of studies on the presentation and management of cholelithiasis in elderly persons from the western part of India. This study aimed to observe the spectrum of presentation and management of symptomatic cholelithiasis in senior citizens. Objectives The primary objective of this study was to describe the presentation, diagnosis and intraoperative findings of symptomatic gallstone disease (GSD) in patients aged over 60 years. The secondary objectives of this study were to find the association of GSD with age, sex, and comorbidities, including diabetes mellitus, hypertension, and thyroid disorders. Methods All patients above the age of 60 years presenting to the surgical outpatient and emergency departments from January 2020 to July 2021 with symptomatic GSD were included. Details of history, physical examination, blood investigations, and imaging of the abdomen (ultrasonography and Magnetic Resonance Cholangiopancreaticography, when indicated) were recorded. Patients were managed as per the advice of the treating consultant. Details of management and outcomes, including hospital stay, mortality, and morbidity, were noted. The descriptive data were organised into tables and percentages. The significance of various data and relationships between various variables was analysed using the Pearson chi-square test, Fischer exact test and scatter plots. Results A total of 76 patients were evaluated in this study, of which 73.7% were female. The mean age was 70.8 ± 1.7 years. The majority of patients (63.2%) were admitted through the outpatient department (OPD). The most common presenting complaint was abdominal pain (96.1%). Clinical jaundice was noted in 9.2%. Complicated Gall Stone Disease (GSD) was found more commonly in the female population (57.1%). Complicated GSD was more commonly found in patients with diabetes (p=0.075) and hypothyroidism (p=0.057). No association of age with intraoperative complications was noted (p = 0.446). Conclusion Senior citizens can present with both complicated and uncomplicated GSD. GSD, in the presence of hypothyroidism or diabetes mellitus, presents in a much more complicated form. Early surgical intervention in form of laparoscopic cholecystectomy can be beneficial to the patient if diagnosed with symptomatic gallstones. Patients of this age group need not be over investigated if a benign pathology is suspected.

[1]  G. Hobbs,et al.  Sex Disparities in the Presentation of Gallbladder Disease , 2021, The American surgeon.

[2]  W. Xie,et al.  Prevalence and risk factors for gallstone disease: A population‐based cross‐sectional study , 2020, Journal of digestive diseases.

[3]  A. García-Botella,et al.  Safety and feasibility of cholecystectomy in octogenarians. Analysis of a single center series of 316 patients. , 2019, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[4]  K. Dono,et al.  Surgical outcomes of laparoscopic cholecystectomy for acute cholecystitis in elderly patients , 2018, Asian journal of endoscopic surgery.

[5]  Tangchun Wu,et al.  Gallstone Disease and Type 2 Diabetes Risk: A Mendelian Randomization Study , 2019, Hepatology.

[6]  T. Hegazy,et al.  Early versus interval laparoscopic cholecystectomy for treatment of noncomplicated acute calcular cholecystitis , 2018 .

[7]  Tariq I. Al-Aubaidi,et al.  Does preoperative magnetic resonant cholangiopancreatography (MRCP), improve the safety of laparoscopic cholecystectomy? , 2018 .

[8]  L. Qi,et al.  Gallstone Disease and the Risk of Type 2 Diabetes , 2017, Scientific Reports.

[9]  Wei-Chih Liao,et al.  How Does Aging Affect Presentation and Management of Biliary Stones? , 2016, Journal of The American Geriatrics Society.

[10]  J. Goodwin,et al.  PREOP-Gallstones: A Prognostic Nomogram for the Management of Symptomatic Cholelithiasis in Older Patients. , 2015, Annals of surgery.

[11]  S. Msika,et al.  A Retrospective Comparison of Older and Younger Adults Undergoing Early Laparoscopic Cholecystectomy for Mild to Moderate Calculous Cholecystitis , 2015, Journal of the American Geriatrics Society.

[12]  S. Bergman,et al.  Recurrence of biliary disease following non-operative management in elderly patients , 2015, Surgical Endoscopy.

[13]  C. Christophi,et al.  Outcomes of cholecystectomy for treatment of acute cholecystitis in octogenarians , 2014, ANZ journal of surgery.

[14]  B. Laway,et al.  Prevalence of gallstone disease in patients with type 2 diabetes and the risk factors in North Indian population: A case control study , 2014, Indian Journal of Gastroenterology.

[15]  G. Romano,et al.  Role and outcomes of laparoscopic cholecystectomy in the elderly. , 2014, International journal of surgery.

[16]  Y. Kurumiya,et al.  Cholecystectomy in octogenarians: be careful , 2014, Updates in Surgery.

[17]  J. Hodson,et al.  Xanthogranulomatous cholecystitis: a European and global perspective. , 2014, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[18]  F. Lammert,et al.  [Biliary diseases in the elderly]. , 2014, Zeitschrift für Gastroenterologie - German Journal of Gastroenterology.

[19]  M. Husain,et al.  Spectrum of histopathological lesions in cholecystectomy specimens: A study of 360 cases at a teaching hospital in South Delhi , 2013 .

[20]  L. Bardram,et al.  Cholecystectomy for the elderly: no hesitation for otherwise healthy patients , 2013, Surgical Endoscopy.

[21]  V. Reshetnyak Concept of the pathogenesis and treatment of cholelithiasis. , 2012, World journal of hepatology.

[22]  T. Riall,et al.  Gallstone pancreatitis in older patients: Are we operating enough? , 2011, Surgery.

[23]  D. N. S. Paulo,et al.  Laparoscopic cholecystectomy in 960 elderly patients. , 2011, Revista do Colegio Brasileiro de Cirurgioes.

[24]  Ghada M. Gaballa,et al.  The value of pre-operative magnetic resonance cholangiopancreatography (MRCP) in management of patients with gall stones. , 2010, International journal of surgery.

[25]  F. Cotta Classification, Composition and Structure of Gallstones. Relevance of these Parameters for Clinical Presentation and Treatment , 2008 .

[26]  C. Haglund,et al.  Increased prevalence of subclinical hypothyroidism in common bile duct stone patients. , 2007, The Journal of clinical endocrinology and metabolism.

[27]  M. Hendrickson,et al.  Abdominal surgical emergencies in the elderly. , 2003, Emergency medicine clinics of North America.

[28]  J. Bender,et al.  Laparoscopic cholecystectomy: applicability in the geriatric population. , 1997, The American surgeon.

[29]  I. Bouchier Gall stones. , 1977, BMJ.