Neurobehavioral changes associated with caudate lesions

We report behavioral and cognitive characteristics of 12 patients with caudate nuclei lesions, 11 unilateral and one bilateral. These patients developed an acute behavioral change characterized by apathy, disinhibition, or a major affective disturbance. The pattern of personality change correlated with size and location of lesion within the caudate but not the laterality. Seven patients were further compared with matched controls on a series of neuropsychological tests. Their performance was impaired on tasks requiring planning and sequencing. They had short attention spans and decreased free recall of episodic and semantic items with good recognition memory scores. Similar behavioral and cognitive changes also occur in early Huntington's disease, frontal-lesioned patients, and caudate-lesioned animals, and correspond to disturbances of specific frontal-caudate circuits. These results implicate the caudate nuclei in mediating prefrontal behaviors and possibly in the conceptual integration of memories.

[1]  C. Pozzilli,et al.  Remote Effects of Caudate Hemorrhage: A Clinical and Functional Study , 1987, Cortex.

[2]  J. Villablanca,et al.  Effects of caudate nuclei or frontal cortical ablations in cats. I. Neurology and gross behavior , 1976, Experimental Neurology.

[3]  R. Hichwa,et al.  Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function , 1988, Annals of neurology.

[4]  A. Cools,et al.  Evidence for a role of the caudate nucleus in the sequential organization of behaviour , 1982, Behavioural Brain Research.

[5]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[6]  J. Villablanca,et al.  Effects of caudate or frontal cortex ablations in cats and kittens: Passive avoidance , 1980, Experimental Neurology.

[7]  I. Shoulson,et al.  Psychiatric syndromes in Huntington's disease. , 1983, The American journal of psychiatry.

[8]  C. Markham,et al.  Cerebral metabolism and atrophy in huntington's disease determined by 18FDG and computed tomographic scan , 1982, Annals of neurology.

[9]  R. D. Hunt,et al.  Huntington's dementia. Clinical and neuropsychological features. , 1978, Archives of general psychiatry.

[10]  D. Stuss,et al.  Neuropsychological studies of the frontal lobes. , 1984, Psychological bulletin.

[11]  D. Delis,et al.  The California verbal learning test , 2016 .

[12]  R. Hichwa,et al.  PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline , 1986, Annals of neurology.

[13]  M. Mishkin,et al.  Comparison of the effects of frontal and caudate lesions on delayed response and alternation in monkeys. , 1960, Journal of comparative and physiological psychology.

[14]  G. Paradiso,et al.  Neurobehavioral symptoms in caudate hemorrhage , 1985, Neurology.

[15]  E. Richfield,et al.  Neurological syndrome following bilateral damage to the head of the caudate nuclei , 1987, Annals of neurology.

[16]  H. E. Rosvold,et al.  Behavioral effects of selective ablation of the caudate nucleus. , 1967, Journal of comparative and physiological psychology.

[17]  R. Kirkby,et al.  Caudate Nucleus Lesions Impair the Ability of Rats to Learn a Simple Straight-Alley Task , 1981, Perceptual and motor skills.

[18]  F. Spellacy,et al.  A short form of the token test. , 1969, Cortex; a journal devoted to the study of the nervous system and behavior.

[19]  D. Kimble,et al.  Avoidance and escape behavior following striatal lesions in the rat. , 1968, Experimental neurology.

[20]  B. Kolb.  Studies on the caudate-putamen and the dorsomedial thalamic nucleus of the rat: Implications for mammalian frontal-lobe functions , 1977, Physiology & Behavior.

[21]  M. Albert,et al.  Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome. , 1986, Archives of neurology.

[22]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.