Fetal autonomic nervous system activity monitoring by spectral analysis of heart rate variations

Using an accurate beat-to-beat detection algorithm for fetal heart rate (FHR) from abdominal electrocardiograms (ECGs) and spectral analysis of heart rate fluctuations, with simultaneous recording of fetal breathing movements (FBMs) by ultrasound imaging, the authors were able to display the continuous activity of the fetal autonomic nervous system (ANS). The continuous display of fetal ANS activity presented may offer an adequate tool for the evaluation of fetal viability. FHR and FBM can be measured by a single procedure. The method provides FHR and FBM as estimated by the power of HR fluctuations reflecting ANS activity in the frequency band related to FBM. Thus, two complementary indications of the fetal viability are obtained simultaneously, from a single noninvasive measurement which allows continuous time dependent monitoring.<<ETX>>

[1]  M. Lishner,et al.  Spectral analysis of fluctuations in heart rate: an objective evaluation of autonomic nervous control in chronic renal failure. , 1987, Nephron.

[2]  L. Devoe,et al.  Value of observation of fetal breathing activity in antenatal assessment of high-risk pregnancy. , 1989, American journal of obstetrics and gynecology.

[3]  R. Cohen,et al.  Hemodynamic regulation: investigation by spectral analysis. , 1985, The American journal of physiology.

[4]  D. Adam,et al.  Assessment of autonomic function in humans by heart rate spectral analysis. , 1985, The American journal of physiology.

[5]  M. Turiel,et al.  Power Spectral Analysis of Heart Rate and Arterial Pressure Variabilities as a Marker of Sympatho‐Vagal Interaction in Man and Conscious Dog , 1986, Circulation research.

[6]  M Y Divon,et al.  Respiratory sinus arrhythmia in the human fetus. , 1985, American journal of obstetrics and gynecology.

[7]  S. Akselrod,et al.  Spectral analysis of heart rate fluctuations. A non-invasive, sensitive method for the early diagnosis of autonomic neuropathy in diabetes mellitus. , 1987, Journal of the autonomic nervous system.

[8]  A. Malliani,et al.  Cardiovascular Neural Regulation Explored in the Frequency Domain , 1991, Circulation.

[9]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[10]  R I Kitney,et al.  Neonatal heart rate variability and its relation to respiration. , 1985, Journal of theoretical biology.

[11]  B. W. Hyndman,et al.  Spontaneous Rhythms in Physiological Control Systems , 1971, Nature.

[12]  M. Rosen,et al.  Regular and irregular human fetal respiratory movement. , 1980, Early human development.

[13]  S Akselrod,et al.  COMPUTERISED DETECTION OF FETAL ECG FROM MATERNAL ABDOMINAL SIGNAL , 1987 .

[14]  THE PRESENCE OR ABSENCE OF FETAL BREATHING MOVEMENTS PREDICTS THE OUTCOME OF PRETERM LABOUR , 1983, The Lancet.

[15]  R. Cohen,et al.  An Efficient Algorithm for Spectral Analysis of Heart Rate Variability , 1986, IEEE Transactions on Biomedical Engineering.