A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

[1]  T. Asselah,et al.  Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[2]  W. Kraft,et al.  Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C , 2012, Antimicrobial Agents and Chemotherapy.

[3]  Hao Jiang,et al.  A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples. , 2011, Analytical chemistry.

[4]  Hao Jiang,et al.  A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[5]  Yuan-Qing Xia,et al.  Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography. , 2010, Biomedical chromatography : BMC.

[6]  Yuan-qing Xia,et al.  Phospholipids in liquid chromatography/mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. , 2009, Rapid communications in mass spectrometry : RCM.

[7]  M. Ghany,et al.  Diagnosis, management, and treatment of hepatitis C: An update , 2009, Hepatology.

[8]  Walter A. Korfmacher,et al.  A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays. , 2005, Rapid communications in mass spectrometry : RCM.

[9]  P. Taylor.  Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. , 2005, Clinical biochemistry.

[10]  B. Matuszewski,et al.  Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. , 2003, Analytical chemistry.

[11]  Wilson Z Shou,et al.  Post-column infusion study of the 'dosing vehicle effect' in the liquid chromatography/tandem mass spectrometric analysis of discovery pharmacokinetic samples. , 2003, Rapid communications in mass spectrometry : RCM.

[12]  Patrick R Griffin,et al.  Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry. , 2002, Analytical chemistry.

[13]  R. Bartenschlager,et al.  Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation , 1995, Journal of virology.