Microwave Assisted Synthesis of Tetrahydrobenzo[b]Pyrans Via One Pot Multicomponent Reaction Using [Et3NH][HSO4] as Ionic Liquid Catalyst

The utility of Ionic Liquids (ILs) for the environmentally benign synthesis of heterocyclic compounds found important for due to their unique chemical and physical properties viz. low vapor pressure, recyclability, controlled miscibility, high thermal and chemical stability. The synthesis of 2-amino5,6,7,8-tetrahydro-7,7-dimethyl-4-(3, 4-substituted phenyl)-5-oxo-4H-chromene-3-carbonitrile or tetrahydrobenzo[b]pyran derivatives were successfully synthesized via one pot multicomponent cyclocondensation reaction of aromatic aldehydes, dimedone and malononitrile utilizing triethylamine hydrogen sulphate [Et3NH][HSO4] as ionic liquid catalyst under solvent free and microwave irradiation method. The reaction was carried to study the optimization of reaction conditions. It was observed that the reaction was best finished when 20 mol% of [Et3NH] [HSO4] ionic liquid catalyst, solvent free and MWI conditions are utilized. The ionic liquid catalyst was recycled for three cycles. Our method represents highly efficient, cheap reusable catalyst and environmentally benign greener protocol for the synthesis of chromene-3-carbonitrile or tetrahydrobenzo[b]pyran derivatives under solvent-free conditions.

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