Federated Learning for Healthcare Informatics

With the rapid development of computer software and hardware technologies, more and more healthcare data are becoming readily available from clinical institutions, patients, insurance companies, and pharmaceutical industries, among others. This access provides an unprecedented opportunity for data science technologies to derive data-driven insights and improve the quality of care delivery. Healthcare data, however, are usually fragmented and private making it difficult to generate robust results across populations. For example, different hospitals own the electronic health records (EHR) of different patient populations and these records are difficult to share across hospitals because of their sensitive nature. This creates a big barrier for developing effective analytical approaches that are generalizable, which need diverse, “big data.” Federated learning, a mechanism of training a shared global model with a central server while keeping all the sensitive data in local institutions where the data belong, provides great promise to connect the fragmented healthcare data sources with privacy-preservation. The goal of this survey is to provide a review for federated learning technologies, particularly within the biomedical space. In particular, we summarize the general solutions to the statistical challenges, system challenges, and privacy issues in federated learning, and point out the implications and potentials in healthcare.

[1]  Reza Shokri,et al.  Comprehensive Privacy Analysis of Deep Learning: Stand-alone and Federated Learning under Passive and Active White-box Inference Attacks , 2018, ArXiv.

[2]  Geoffrey E. Hinton,et al.  Distilling the Knowledge in a Neural Network , 2015, ArXiv.

[3]  Hanlin Tang,et al.  Central Server Free Federated Learning over Single-sided Trust Social Networks , 2019, ArXiv.

[4]  Guan Wang,et al.  Interpret Federated Learning with Shapley Values , 2019, ArXiv.

[5]  João Carlos Gluz,et al.  Interdisciplinary Journal of E-learning and Learning Objects an Agent-based Federated Learning Object Search Service , 2022 .

[6]  Qiang Yang,et al.  SecureBoost: A Lossless Federated Learning Framework , 2019, IEEE Intelligent Systems.

[7]  Yang Liu,et al.  Secure Federated Transfer Learning , 2018, ArXiv.

[8]  Yu-Chuan Li,et al.  Observational Health Data Sciences and Informatics (OHDSI): Opportunities for Observational Researchers , 2015, MedInfo.

[9]  Binhang Yuan,et al.  A Federated Learning Framework for Healthcare IoT devices , 2020, ArXiv.

[10]  R. Detrano,et al.  International application of a new probability algorithm for the diagnosis of coronary artery disease. , 1989, The American journal of cardiology.

[11]  Zixuan Liu,et al.  Learning from electronic health records across multiple sites: A communication-efficient and privacy-preserving distributed algorithm , 2019, J. Am. Medical Informatics Assoc..

[12]  Riccardo Miotto,et al.  Federated Learning of Electronic Health Records Improves Mortality Prediction in Patients Hospitalized with COVID-19 , 2020, medRxiv.

[13]  H. Brendan McMahan,et al.  Differentially Private Learning with Adaptive Clipping , 2019, NeurIPS.

[14]  Kannan Ramchandran,et al.  Robust Federated Learning in a Heterogeneous Environment , 2019, ArXiv.

[15]  Sebastian Mate,et al.  KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services , 2019, PloS one.

[16]  Ying-Chang Liang,et al.  Incentive Design for Efficient Federated Learning in Mobile Networks: A Contract Theory Approach , 2019, 2019 IEEE VTS Asia Pacific Wireless Communications Symposium (APWCS).

[17]  Ameet Talwalkar,et al.  One-Shot Federated Learning , 2019, ArXiv.

[18]  Kai Chen,et al.  Secure Federated Matrix Factorization , 2019, IEEE Intelligent Systems.

[19]  Song Han,et al.  Deep Compression: Compressing Deep Neural Network with Pruning, Trained Quantization and Huffman Coding , 2015, ICLR.

[20]  Dong In Kim,et al.  Efficient Training Management for Mobile Crowd-Machine Learning: A Deep Reinforcement Learning Approach , 2018, IEEE Wireless Communications Letters.

[21]  Farah E. Shamout,et al.  Preserving Patient Privacy while Training a Predictive Model of In-hospital Mortality , 2019, ArXiv.

[22]  Sebastian Caldas,et al.  Expanding the Reach of Federated Learning by Reducing Client Resource Requirements , 2018, ArXiv.

[23]  Peter Richtárik,et al.  Distributed Coordinate Descent Method for Learning with Big Data , 2013, J. Mach. Learn. Res..

[24]  Bruno Sericola,et al.  MD-GAN: Multi-Discriminator Generative Adversarial Networks for Distributed Datasets , 2018, 2019 IEEE International Parallel and Distributed Processing Symposium (IPDPS).

[25]  Sandeep Kaushik,et al.  Big data in healthcare: management, analysis and future prospects , 2019, Journal of Big Data.

[26]  Han Yu,et al.  Threats to Federated Learning: A Survey , 2020, ArXiv.

[27]  Fei Chen,et al.  Federated Meta-Learning with Fast Convergence and Efficient Communication , 2018 .

[28]  Peter Groves,et al.  The 'big data' revolution in healthcare: Accelerating value and innovation , 2016 .

[29]  Richard Nock,et al.  Private federated learning on vertically partitioned data via entity resolution and additively homomorphic encryption , 2017, ArXiv.

[30]  Patrick Hill,et al.  The Rationale for Learning Communities and Learning Community Models. , 1985 .

[31]  Xu Chen,et al.  In-Edge AI: Intelligentizing Mobile Edge Computing, Caching and Communication by Federated Learning , 2018, IEEE Network.

[32]  Michael J. Watts,et al.  IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS Publication Information , 2020, IEEE Transactions on Neural Networks and Learning Systems.

[33]  Hubert Eichner,et al.  APPLIED FEDERATED LEARNING: IMPROVING GOOGLE KEYBOARD QUERY SUGGESTIONS , 2018, ArXiv.

[34]  Joseph Dureau,et al.  Federated Learning for Keyword Spotting , 2018, ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP).

[35]  Peter Szolovits,et al.  MIMIC-III, a freely accessible critical care database , 2016, Scientific Data.

[36]  Yue Zhao,et al.  Federated Learning with Non-IID Data , 2018, ArXiv.

[37]  Moming Duan,et al.  Astraea: Self-Balancing Federated Learning for Improving Classification Accuracy of Mobile Deep Learning Applications , 2019, 2019 IEEE 37th International Conference on Computer Design (ICCD).

[38]  Peter Richtárik,et al.  Fast distributed coordinate descent for non-strongly convex losses , 2014, 2014 IEEE International Workshop on Machine Learning for Signal Processing (MLSP).

[39]  Maria-Florina Balcan,et al.  Distributed Learning, Communication Complexity and Privacy , 2012, COLT.

[40]  Xiaoyan Sun,et al.  Communication-Efficient Federated Deep Learning With Layerwise Asynchronous Model Update and Temporally Weighted Aggregation , 2019, IEEE Transactions on Neural Networks and Learning Systems.

[41]  Carmela Troncoso,et al.  Disparate Vulnerability: on the Unfairness of Privacy Attacks Against Machine Learning , 2019, ArXiv.

[42]  Xiang Li,et al.  On the Convergence of FedAvg on Non-IID Data , 2019, ICLR.

[43]  Karen Kellogg Learning Communities. ERIC Digest. , 1999 .

[44]  Vitaly Shmatikov,et al.  How To Backdoor Federated Learning , 2018, AISTATS.

[45]  Guanding Yu,et al.  Accelerating DNN Training in Wireless Federated Edge Learning Systems , 2019, IEEE Journal on Selected Areas in Communications.

[46]  Hubert Eichner,et al.  Towards Federated Learning at Scale: System Design , 2019, SysML.

[47]  Maria-Florina Balcan,et al.  Adaptive Gradient-Based Meta-Learning Methods , 2019, NeurIPS.

[48]  Antoine Guisan,et al.  A minimalist model of extinction and range dynamics of virtual mountain species driven by warming temperatures , 2019, PloS one.

[49]  Paul Voigt,et al.  The EU General Data Protection Regulation (GDPR) , 2017 .

[50]  Peter Richtárik,et al.  Federated Optimization: Distributed Machine Learning for On-Device Intelligence , 2016, ArXiv.

[51]  David M. Nicol,et al.  unFriendly: Multi-party Privacy Risks in Social Networks , 2010, Privacy Enhancing Technologies.

[52]  Hubert Eichner,et al.  Federated Learning for Mobile Keyboard Prediction , 2018, ArXiv.

[53]  Joachim M. Buhmann,et al.  Variational Federated Multi-Task Learning , 2019, ArXiv.

[54]  H. Brendan McMahan,et al.  Learning Differentially Private Recurrent Language Models , 2017, ICLR.

[55]  Jakub Konecný,et al.  Federated Optimization: Distributed Optimization Beyond the Datacenter , 2015, ArXiv.

[56]  Qiang Yang,et al.  Federated Machine Learning , 2019, ACM Trans. Intell. Syst. Technol..

[57]  Wei Pan,et al.  Towards Accurate Binary Convolutional Neural Network , 2017, NIPS.

[58]  Ameet Talwalkar,et al.  Federated Multi-Task Learning , 2017, NIPS.

[59]  Peter Richtárik,et al.  Federated Learning: Strategies for Improving Communication Efficiency , 2016, ArXiv.

[60]  Moni Naor,et al.  Our Data, Ourselves: Privacy Via Distributed Noise Generation , 2006, EUROCRYPT.

[61]  Tassilo Klein,et al.  Differentially Private Federated Learning: A Client Level Perspective , 2017, ArXiv.

[62]  Haithum Elhadi,et al.  Federated Uncertainty-Aware Learning for Distributed Hospital EHR Data , 2019, ArXiv.

[63]  Aris Gkoulalas-Divanis,et al.  Predicting Adverse Drug Reactions on Distributed Health Data using Federated Learning , 2020, AMIA.

[64]  Ying-Chang Liang,et al.  Joint Service Pricing and Cooperative Relay Communication for Federated Learning , 2018, 2019 International Conference on Internet of Things (iThings) and IEEE Green Computing and Communications (GreenCom) and IEEE Cyber, Physical and Social Computing (CPSCom) and IEEE Smart Data (SmartData).

[65]  Masahiro Morikura,et al.  Hybrid-FL for Wireless Networks: Cooperative Learning Mechanism Using Non-IID Data , 2019, ICC 2020 - 2020 IEEE International Conference on Communications (ICC).

[66]  Dmitriy Dligach,et al.  Two-stage Federated Phenotyping and Patient Representation Learning , 2019, BioNLP@ACL.

[67]  Ramesh Raskar,et al.  Split learning for health: Distributed deep learning without sharing raw patient data , 2018, ArXiv.

[68]  Walid Saad,et al.  Federated Learning for Ultra-Reliable Low-Latency V2V Communications , 2018, 2018 IEEE Global Communications Conference (GLOBECOM).

[69]  Indranil Gupta,et al.  Asynchronous Federated Optimization , 2019, ArXiv.

[70]  Zhiwei Steven Wu,et al.  Distributed Training with Heterogeneous Data: Bridging Median- and Mean-Based Algorithms , 2019, NeurIPS.

[71]  Davide Anguita,et al.  Human Activity Recognition on Smartphones Using a Multiclass Hardware-Friendly Support Vector Machine , 2012, IWAAL.

[72]  Yasaman Khazaeni,et al.  Bayesian Nonparametric Federated Learning of Neural Networks , 2019, ICML.

[73]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[74]  Mehryar Mohri,et al.  Agnostic Federated Learning , 2019, ICML.

[75]  S. Brunak,et al.  Mining electronic health records: towards better research applications and clinical care , 2012, Nature Reviews Genetics.

[76]  Kunle Olukotun,et al.  High-Accuracy Low-Precision Training , 2018, ArXiv.

[77]  Fei Wang,et al.  Deep learning for healthcare: review, opportunities and challenges , 2018, Briefings Bioinform..

[78]  Swaroop Ramaswamy,et al.  Federated Learning for Emoji Prediction in a Mobile Keyboard , 2019, ArXiv.

[79]  Blaise Agüera y Arcas,et al.  Communication-Efficient Learning of Deep Networks from Decentralized Data , 2016, AISTATS.

[80]  Ivan Beschastnikh,et al.  Mitigating Sybils in Federated Learning Poisoning , 2018, ArXiv.

[81]  Seong-Lyun Kim,et al.  Blockchained On-Device Federated Learning , 2018, IEEE Communications Letters.

[82]  Richard E. Turner,et al.  Partitioned Variational Inference: A unified framework encompassing federated and continual learning , 2018, ArXiv.

[83]  Anand D. Sarwate,et al.  A near-optimal algorithm for differentially-private principal components , 2012, J. Mach. Learn. Res..

[84]  Milind Kulkarni,et al.  Survey of Personalization Techniques for Federated Learning , 2020, 2020 Fourth World Conference on Smart Trends in Systems, Security and Sustainability (WorldS4).

[85]  Markus Fiedler,et al.  Privacy Preserving QoE Modeling using Collaborative Learning , 2019, Internet-QoE'19.

[86]  Anit Kumar Sahu,et al.  Federated Optimization in Heterogeneous Networks , 2018, MLSys.

[87]  Mats Jirstrand,et al.  Functional Federated Learning in Erlang (ffl-erl) , 2018, WFLP.

[88]  Jimeng Sun,et al.  Federated Tensor Factorization for Computational Phenotyping , 2017, KDD.

[89]  Amir Houmansadr,et al.  Comprehensive Privacy Analysis of Deep Learning: Passive and Active White-box Inference Attacks against Centralized and Federated Learning , 2018, 2019 IEEE Symposium on Security and Privacy (SP).

[90]  Tom Ouyang,et al.  Federated Learning Of Out-Of-Vocabulary Words , 2019, ArXiv.

[91]  Ramesh Raskar,et al.  Distributed learning of deep neural network over multiple agents , 2018, J. Netw. Comput. Appl..

[92]  L. Gostin,et al.  National health information privacy: regulations under the Health Insurance Portability and Accountability Act. , 2001, JAMA.

[93]  Tara Javidi,et al.  Decentralized Bayesian Learning over Graphs , 2019, ArXiv.

[94]  Gaurav Kapoor,et al.  Protection Against Reconstruction and Its Applications in Private Federated Learning , 2018, ArXiv.

[95]  Ivan Beschastnikh,et al.  Biscotti: A Ledger for Private and Secure Peer-to-Peer Machine Learning , 2018, ArXiv.

[96]  Qiang Yang,et al.  Federated Deep Reinforcement Learning , 2019, 1901.08277.

[97]  Badih Ghazi,et al.  Scalable and Differentially Private Distributed Aggregation in the Shuffled Model , 2019, ArXiv.

[98]  Jun Zhao,et al.  Mobile Edge Computing, Blockchain and Reputation-based Crowdsourcing IoT Federated Learning: A Secure, Decentralized and Privacy-preserving System , 2019, ArXiv.

[99]  Rui Zhang,et al.  A Hybrid Approach to Privacy-Preserving Federated Learning , 2018, Informatik Spektrum.

[100]  Yang Song,et al.  Beyond Inferring Class Representatives: User-Level Privacy Leakage From Federated Learning , 2018, IEEE INFOCOM 2019 - IEEE Conference on Computer Communications.

[101]  M. Deshpande,et al.  International Research Journal of Engineering and Technology (IRJET) , 2016 .

[102]  Ying-Chang Liang,et al.  Federated Learning in Mobile Edge Networks: A Comprehensive Survey , 2020, IEEE Communications Surveys & Tutorials.

[103]  Yaochu Jin,et al.  Multi-Objective Evolutionary Federated Learning , 2018, IEEE Transactions on Neural Networks and Learning Systems.

[104]  Sreeram Kannan,et al.  Improving Federated Learning Personalization via Model Agnostic Meta Learning , 2019, ArXiv.

[105]  Song Han,et al.  Learning both Weights and Connections for Efficient Neural Network , 2015, NIPS.

[106]  Wei Zhang,et al.  Can Decentralized Algorithms Outperform Centralized Algorithms? A Case Study for Decentralized Parallel Stochastic Gradient Descent , 2017, NIPS.

[107]  Nathan Srebro,et al.  Semi-Cyclic Stochastic Gradient Descent , 2019, ICML.

[108]  Ling Huang,et al.  Learning in a Large Function Space: Privacy-Preserving Mechanisms for SVM Learning , 2009, J. Priv. Confidentiality.

[109]  Nassir Navab,et al.  BrainTorrent: A Peer-to-Peer Environment for Decentralized Federated Learning , 2019, ArXiv.

[110]  Xiaoqian Jiang,et al.  Privacy Preserving Federated Big Data Analysis , 2018 .

[111]  Daniel Rueckert,et al.  Robust Aggregation for Adaptive Privacy Preserving Federated Learning in Healthcare , 2020, ArXiv.

[112]  Xiaoyan Sun,et al.  Communication-Efficient Federated Deep Learning With Layerwise Asynchronous Model Update and Temporally Weighted Aggregation , 2019, IEEE Transactions on Neural Networks and Learning Systems.

[113]  Wei Shi,et al.  Federated learning of predictive models from federated Electronic Health Records , 2018, Int. J. Medical Informatics.

[114]  Xiangliang Zhang,et al.  Robust Federated Training via Collaborative Machine Teaching using Trusted Instances , 2019, ArXiv.

[115]  Ivan Beschastnikh,et al.  Dancing in the Dark: Private Multi-Party Machine Learning in an Untrusted Setting , 2018, ArXiv.

[116]  Zhi Ding,et al.  Federated Learning via Over-the-Air Computation , 2018, IEEE Transactions on Wireless Communications.

[117]  Richard S. Johannes,et al.  Using the ADAP Learning Algorithm to Forecast the Onset of Diabetes Mellitus , 1988 .

[118]  Takayuki Nishio,et al.  Client Selection for Federated Learning with Heterogeneous Resources in Mobile Edge , 2018, ICC 2019 - 2019 IEEE International Conference on Communications (ICC).

[119]  Qiao Li,et al.  The PhysioNet/Computing in Cardiology Challenge 2015: Reducing false arrhythmia alarms in the ICU , 2015, 2015 Computing in Cardiology Conference (CinC).

[120]  Alistair E. W. Johnson,et al.  The eICU Collaborative Research Database, a freely available multi-center database for critical care research , 2018, Scientific Data.

[121]  Nathan Srebro,et al.  Graph Oracle Models, Lower Bounds, and Gaps for Parallel Stochastic Optimization , 2018, NeurIPS.

[122]  Prateek Mittal,et al.  Analyzing Federated Learning through an Adversarial Lens , 2018, ICML.

[123]  Daniel R. Rehak,et al.  A Model and Infrastructure for Federated Learning Content Repositories , 2005 .

[124]  Li Huang,et al.  Patient Clustering Improves Efficiency of Federated Machine Learning to predict mortality and hospital stay time using distributed Electronic Medical Records , 2019, J. Biomed. Informatics.

[125]  Klaus-Robert Müller,et al.  Robust and Communication-Efficient Federated Learning From Non-i.i.d. Data , 2019, IEEE Transactions on Neural Networks and Learning Systems.

[126]  Fei Wang,et al.  Predictive Modeling of the Hospital Readmission Risk from Patients’ Claims Data Using Machine Learning: A Case Study on COPD , 2019, Scientific Reports.

[127]  Mats Jirstrand,et al.  OODIDA: On-Board/Off-Board Distributed Real-Time Data Analytics for Connected Vehicles , 2019, Data Science and Engineering.

[128]  Sanjiv Kumar,et al.  cpSGD: Communication-efficient and differentially-private distributed SGD , 2018, NeurIPS.

[129]  Vitaly Shmatikov,et al.  Privacy-preserving deep learning , 2015, 2015 53rd Annual Allerton Conference on Communication, Control, and Computing (Allerton).

[130]  Khe Chai Sim,et al.  An Investigation Into On-device Personalization of End-to-end Automatic Speech Recognition Models , 2019, INTERSPEECH.

[131]  E. Sivasankar,et al.  Modern Framework for Distributed Healthcare Data Analytics Based on Hadoop , 2014, ICT-EurAsia.

[132]  Richard Nock,et al.  Advances and Open Problems in Federated Learning , 2021, Found. Trends Mach. Learn..

[133]  Caroline Fontaine,et al.  A Survey of Homomorphic Encryption for Nonspecialists , 2007, EURASIP J. Inf. Secur..

[134]  Peter B. Walker,et al.  Federated Patient Hashing , 2020, AAAI.

[135]  Lars Kai Hansen,et al.  Active Learning Solution on Distributed Edge Computing , 2019, ArXiv.

[136]  Viju Raghupathi,et al.  Big data analytics in healthcare: promise and potential , 2014, Health Information Science and Systems.

[137]  Ian Goodfellow,et al.  Deep Learning with Differential Privacy , 2016, CCS.

[138]  Adam D. Smith,et al.  Distributed Differential Privacy via Shuffling , 2018, IACR Cryptol. ePrint Arch..

[139]  Marco V Perez,et al.  Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. , 2019, The New England journal of medicine.

[140]  Mats Jirstrand,et al.  OODIDA: On-board/Off-board Distributed Data Analytics for Connected Vehicles , 2019, ArXiv.

[141]  David Silver,et al.  Deep Reinforcement Learning with Double Q-Learning , 2015, AAAI.

[142]  Kipp W. Johnson,et al.  The next generation of precision medicine: observational studies, electronic health records, biobanks and continuous monitoring. , 2018, Human molecular genetics.

[143]  Fei Wang,et al.  Privacy-Preserving Patient Similarity Learning in a Federated Environment: Development and Analysis , 2018, JMIR medical informatics.

[144]  Li Huang,et al.  LoAdaBoost: Loss-based AdaBoost federated machine learning with reduced computational complexity on IID and non-IID intensive care data , 2018, PloS one.

[145]  Xin Qin,et al.  FedHealth: A Federated Transfer Learning Framework for Wearable Healthcare , 2019, IEEE Intelligent Systems.

[146]  U. Rajendra Acharya,et al.  Machine Learning in Healthcare Informatics , 2013, Machine Learning in Healthcare Informatics.

[147]  Guy N. Rothblum,et al.  Boosting and Differential Privacy , 2010, 2010 IEEE 51st Annual Symposium on Foundations of Computer Science.

[148]  Ming Liu,et al.  Lifelong Federated Reinforcement Learning: A Learning Architecture for Navigation in Cloud Robotic Systems , 2019, IEEE Robotics and Automation Letters.

[149]  Ohad Shamir,et al.  Optimal Distributed Online Prediction Using Mini-Batches , 2010, J. Mach. Learn. Res..

[150]  Hao Deng,et al.  LoAdaBoost: Loss-Based AdaBoost Federated Machine Learning on medical Data , 2018, ArXiv.

[151]  Tian Li,et al.  Fair Resource Allocation in Federated Learning , 2019, ICLR.

[152]  Sarvar Patel,et al.  Practical Secure Aggregation for Privacy-Preserving Machine Learning , 2017, IACR Cryptol. ePrint Arch..

[153]  Paul Voigt,et al.  The Eu General Data Protection Regulation (Gdpr): A Practical Guide , 2017 .

[154]  Qiang Yang,et al.  Federated Reinforcement Learning , 2019, ArXiv.

[155]  Paul M. Thompson,et al.  Federated Learning in Distributed Medical Databases: Meta-Analysis of Large-Scale Subcortical Brain Data , 2018, 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019).

[156]  Natalia Criado,et al.  Multiparty privacy in social media , 2018, Commun. ACM.

[157]  Brian W. Powers,et al.  Dissecting racial bias in an algorithm used to manage the health of populations , 2019, Science.

[158]  Daniel Rueckert,et al.  A generic framework for privacy preserving deep learning , 2018, ArXiv.

[159]  Zhenguo Li,et al.  Federated Meta-Learning for Recommendation , 2018, ArXiv.

[160]  Bo Li,et al.  Differentially Private Data Generative Models , 2018, ArXiv.

[161]  Aris Gkoulalas-Divanis,et al.  Differential Privacy-enabled Federated Learning for Sensitive Health Data , 2019, ArXiv.

[162]  Antti Honkela,et al.  Learning rate adaptation for federated and differentially private learning , 2018, 1809.03832.

[163]  Sebastian Caldas,et al.  LEAF: A Benchmark for Federated Settings , 2018, ArXiv.

[164]  Xiaoqian Jiang,et al.  Distributed learning from multiple EHR databases: Contextual embedding models for medical events , 2019, J. Biomed. Informatics.

[165]  Pietro Perona,et al.  The Caltech-UCSD Birds-200-2011 Dataset , 2011 .

[166]  Stefan Wrobel,et al.  Efficient Decentralized Deep Learning by Dynamic Model Averaging , 2018, ECML/PKDD.

[167]  A. Rajagopal,et al.  Federated AI lets a team imagine together: Federated Learning of GANs , 2019, ArXiv.

[168]  Tara Javidi,et al.  Peer-to-peer Federated Learning on Graphs , 2019, ArXiv.

[169]  Andrew M. Dai,et al.  Federated and Differentially Private Learning for Electronic Health Records , 2019, ArXiv.

[170]  Bhiksha Raj,et al.  Multiparty Differential Privacy via Aggregation of Locally Trained Classifiers , 2010, NIPS.

[171]  Fei Wang,et al.  AI in Health: State of the Art, Challenges, and Future Directions , 2019, Yearbook of Medical Informatics.