Pseudo-nucléosides dérivés des pyrrolo[2, 3-d]pyrimidines. Synthèse et activité biologique

Une nouvelle serie de pseudonucleosides a ete obtenue par condensation de differents amino-pentopyrannoses sur une dichloro-4, 6 acetonyl-5 pyrimidine. La cyclisation en pyrrolo[2, 3-d]pyrimidine conduit ainsi en une seule etape, a de nouveaux analogues de la Tubercidine. Certains d'entre eux presentent une activite contre le virus de la vaccine et le virus sindbis. A new series of pseudonucleosides has been obtained by condensation of various aminopentopyranoses on a 4,6-dichloro-5-acetonylpyrimidine. Cyclisation into pyrrolo[2,3-d] pyrimidine leads in one step to new tubercidin analogs. Some of them exhibit significant antiviral activity toward vaccinia virus and Sindbis virus.

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