PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells
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Y. Kido | S. Maeda | T. Noda | M. Kasuga | T. Uchida | W. Ogawa | N. Hashimoto | T. Matsuda | K. Akimoto | Y. Ueta | M. Matsumoto | Y. Uchiyama | H. Inoue | S. Ohno | H. Fujihara | Kazuhisa Suzuki | Naoko Hashimoto | Tomokazu Matsuda
[1] K. Akimoto,et al. Protein Kinase C λ/ι (PKCλ/ι): A PKC Isotype Essential for the Development of Multicellular Organisms , 2003 .
[2] S. Moriya,et al. EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3‐kinase. , 1996, The EMBO journal.
[3] K. Kaestner,et al. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. , 2001, Genes & development.
[4] G. Bjørkøy,et al. Nuclear Import and Export Signals Enable Rapid Nucleocytoplasmic Shuttling of the Atypical Protein Kinase C λ* , 2001, The Journal of Biological Chemistry.
[5] T. Ohnishi,et al. Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures , 2001, The Journal of cell biology.
[6] M. Birnbaum,et al. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 , 1997, Nature Genetics.
[7] J. Richardson,et al. Essential Role of STAT3 in Body Weight and Glucose Homeostasis , 2004, Molecular and Cellular Biology.
[8] M. Kasuga,et al. Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport , 1998, Molecular and Cellular Biology.
[9] K. Kaestner,et al. Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo , 2002 .
[10] F. Piano,et al. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. , 1998, Development.
[11] H. Motoshima,et al. Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) an , 1999, Endocrine journal.
[12] T. Noda,et al. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. , 2003, The Journal of clinical investigation.
[13] Y. Matsuzawa,et al. Identification of missense mutations in the hepatocyte nuclear factor-3β gene in Japanese subjects with late-onset Type II diabetes mellitus , 2000, Diabetologia.
[14] P. Cohen,et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells , 2000, Current Biology.
[15] E. Furth,et al. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα , 2001, Nature Medicine.
[16] Hj. Müller. Genetic control of epithelial cell polarity: Lessons from Drosophila , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.
[17] M. Kasuga,et al. Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes. , 1997, Molecular endocrinology.
[18] M. White,et al. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling , 1999, Nature Genetics.
[19] Y. Kido,et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. , 2000, The Journal of clinical investigation.
[20] L. Aguilar-Bryan,et al. Sur1 Knockout Mice , 2000, The Journal of Biological Chemistry.
[21] M. Prentki,et al. Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation , 2001 .
[22] Haiyan Wang,et al. Foxa2 (HNF3β) Controls Multiple Genes Implicated in Metabolism-Secretion Coupling of Glucose-induced Insulin Release* , 2002, The Journal of Biological Chemistry.
[23] C. Schmitz‐Peiffer,et al. Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. , 1993, The Journal of biological chemistry.
[24] D. Porte. β-cells in type II diabetes mellitus , 1991, Diabetes.
[25] Y. Kido,et al. Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor , 2001, Molecular and Cellular Biology.
[26] C. Kahn,et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. , 2001, Molecular cell.
[27] M. Magnuson,et al. Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.
[28] C. Kahn,et al. Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes , 1999, Cell.
[29] L. Denner,et al. Protein kinase Ciota enhances the transcriptional activity of the porcine P-450 side-chain cleavage insulin-like response element. , 2004, American journal of physiology. Endocrinology and metabolism.
[30] C. Doe,et al. Asymmetric cell division: fly neuroblast meets worm zygote. , 2001, Current opinion in cell biology.
[31] G. Rutter,et al. Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. , 2004, The Biochemical journal.
[32] M. Permutt,et al. Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia , 2001 .
[33] Y. Kido,et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. , 2002, The Journal of clinical investigation.
[34] P. Berggren,et al. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. , 1998, Molecular cell.
[35] G. Bjørkøy,et al. Reversion of Ras- and Phosphatidylcholine-hydrolyzing Phospholipase C-mediated Transformation of NIH 3T3 Cells by a Dominant Interfering Mutant of Protein Kinase C λ Is Accompanied by the Loss of Constitutive Nuclear Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Activity* , 1997, The Journal of Biological Chemistry.
[36] Y. Kido,et al. Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and β-Cell Compensation to Insulin Resistance* , 2002, The Journal of Biological Chemistry.
[37] M. Kasuga,et al. Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes , 1998, Molecular and Cellular Biology.
[38] M. Stoffel,et al. β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass , 2002, Nature Genetics.
[39] Y. Kido,et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo , 2004, Nature Medicine.
[40] C. Rhodes,et al. IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication. , 2000, Journal of molecular endocrinology.
[41] E. Furth,et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. , 2001, Nature medicine.
[42] P. Jones,et al. Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Gö 6976 and Ro 31-8220 as Pkc inhibitors. , 1996, Biochemical and biophysical research communications.
[43] J. Avruch,et al. Atypical protein kinase Clambda binds and regulates p70 S6 kinase. , 1998, The Biochemical journal.
[44] J. Miyazaki,et al. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[45] R. Unger. Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications , 1995, Diabetes.
[46] C. Burns,et al. Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets. , 1999, Journal of molecular endocrinology.
[47] J. H. Johnson,et al. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. , 1994, The Journal of biological chemistry.
[48] R. Burcelin,et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.