Gastrodin destabilizes survivin and overcomes pemetrexed resistance.

[1]  Aling Shen,et al.  Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation , 2023, Pharmaceutical biology.

[2]  G. Cao,et al.  GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy. , 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  Li Zhou,et al.  Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway , 2023, Journal of biochemical and molecular toxicology.

[4]  Ling Li,et al.  Gastrodin ameliorates atherosclerosis by inhibiting foam cells formation and inflammation through down-regulating NF-κB pathway , 2023, Nutrition & Metabolism.

[5]  Cheng-hong Xiao,et al.  Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice. , 2023, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[6]  Wei Cui,et al.  TRAF4-mediated ubiquitination-dependent activation of JNK/Bcl-xL drives radioresistance , 2023, Cell Death & Disease.

[7]  Wei Li,et al.  Survivin Small Molecules Inhibitors: Recent Advances and Challenges , 2023, Molecules.

[8]  Jiajia Wu,et al.  Non-Small Cell Lung Cancer Targeted Therapy: Drugs and Mechanisms of Drug Resistance , 2022, International journal of molecular sciences.

[9]  G. Sheu,et al.  miR-145-5p Targets Sp1 in Non-Small Cell Lung Cancer Cells and Links to BMI1 Induced Pemetrexed Resistance and Epithelial–Mesenchymal Transition , 2022, International journal of molecular sciences.

[10]  F. Gao,et al.  Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance , 2022, Cell Death & Disease.

[11]  Wenbing Liu,et al.  Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance , 2022, Scientific Reports.

[12]  Lin Sun,et al.  Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion , 2022, Frontiers in Pharmacology.

[13]  S. Woo,et al.  Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5 , 2022, Cell Death & Disease.

[14]  S. Ramakrishna,et al.  Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. , 2022, Molecular therapy : the journal of the American Society of Gene Therapy.

[15]  F. A. Rossi,et al.  Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development , 2022, Frontiers in Cell and Developmental Biology.

[16]  C. Zhan,et al.  miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways , 2022, Molecular therapy. Nucleic acids.

[17]  Xiaoyi Mi,et al.  Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway , 2022, BioMed research international.

[18]  C. Ung,et al.  Clinical and economic analysis of Gastrodin injection for dizziness or vertigo: a retrospective cohort study based on electronic health records in China , 2022, Chinese Medicine.

[19]  M. Shao,et al.  Gastrodin inhibits high glucose-induced inflammation, oxidative stress and apoptosis in podocytes by activating the AMPK/Nrf2 signaling pathway , 2021, Experimental and therapeutic medicine.

[20]  Juan Yu,et al.  USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy , 2021, Autophagy.

[21]  F. Gao,et al.  Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer , 2021, Cell Death & Disease.

[22]  Ji Yoon Lee,et al.  Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Protect Cardiomyocytes from Doxorubicin-Induced Cardiomyopathy by Upregulating Survivin Expression via the miR-199a-3p-Akt-Sp1/p53 Signaling Pathway , 2021, International journal of molecular sciences.

[23]  R. Bosch,et al.  Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity , 2021, Cellular Oncology.

[24]  Chan-Min Liu,et al.  Nephroprotective effect of gastrodin against lead-induced oxidative stress and inflammation in mice by the GSH, Trx, Nrf2 antioxidant system, and the HMGB1 pathway. , 2021, Toxicology research.

[25]  Y. Hao,et al.  Global patterns and trends in lung cancer incidence: a population-based study. , 2021, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[26]  Xiao Tan,et al.  Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models , 2021, Drug and chemical toxicology.

[27]  E. Imyanitov,et al.  Molecular testing and targeted therapy for non-small cell lung cancer: current status and perspectives. , 2020, Critical reviews in oncology/hematology.

[28]  F. Gao,et al.  Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance , 2020, Cell Death & Disease.

[29]  Wenbin Liu,et al.  Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells , 2020, Journal of cellular and molecular medicine.

[30]  Zhiyong Guo,et al.  USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy , 2020, Cellular & Molecular Immunology.

[31]  P. Agarwal,et al.  Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics , 2020, Stem Cell Reviews and Reports.

[32]  Toshio Shimizu,et al.  Phase I safety and pharmacokinetic study of YM155, a potent selective survivin inhibitor, in combination with erlotinib in patients with EGFR TKI refractory advanced non-small cell lung cancer , 2020, Cancer Chemotherapy and Pharmacology.

[33]  Wenbin Liu,et al.  Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis , 2020, Cell Death & Disease.

[34]  Wenbin Liu,et al.  Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma , 2020, Journal of experimental & clinical cancer research : CR.

[35]  L. Li,et al.  Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron , 2020, Human & experimental toxicology.

[36]  N. Samadi,et al.  Phosphorylation Modulates Survivin Function in Behcet’s Disease , 2020, Advanced pharmaceutical bulletin.

[37]  Yongfu Ma,et al.  Elevated SRC3 expression predicts pemetrexed resistance in lung adenocarcinoma. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[38]  Wenbin Liu,et al.  Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization , 2020, Cell Death & Disease.

[39]  C. Zhan,et al.  Mechanisms of resistance to pemetrexed in non-small cell lung cancer. , 2019, Translational lung cancer research.

[40]  Yue Du,et al.  Drug resistance to targeted therapeutic strategies in non-small cell lung cancer. , 2019, Pharmacology & therapeutics.

[41]  P. Dong,et al.  Ovarian Primary and Metastatic Tumors Suppressed by Survivin Knockout or a Novel Survivin Inhibitor , 2019, Molecular Cancer Therapeutics.

[42]  Li Zhang,et al.  Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines. , 2019, International immunopharmacology.

[43]  D. Altieri,et al.  Survivin at a glance , 2019, Journal of Cell Science.

[44]  R. Basha,et al.  Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors , 2018, Cellular Physiology and Biochemistry.

[45]  S. Wing,et al.  The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice , 2018, Diabetologia.

[46]  Jing Li,et al.  Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance , 2018, Cell Death & Disease.

[47]  Yuan Xu,et al.  A Review on Central Nervous System Effects of Gastrodin , 2018, Front. Pharmacol..

[48]  T. Bivona,et al.  Understanding and targeting resistance mechanisms in NSCLC , 2017, Nature Reviews Cancer.

[49]  S. Hsu,et al.  Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[50]  F. Tinahones,et al.  Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis , 2017, Cell Death & Disease.

[51]  Jian Yang,et al.  Enhanced expression of Survivin has distinct roles in adipocyte homeostasis , 2017, Cell Death & Disease.

[52]  Mark N. Wass,et al.  Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance , 2016, Cell Death and Disease.

[53]  P. Dundr,et al.  Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells , 2016, Cell Death and Disease.

[54]  R. Schmid,et al.  Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer , 2015, Cell Death and Disease.

[55]  James M. Bogenberger,et al.  Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias , 2015, Investigational New Drugs.

[56]  Bill B. Chen,et al.  The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin* , 2015, The Journal of Biological Chemistry.

[57]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[58]  S. Wing,et al.  USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling , 2015, Molecular biology of the cell.

[59]  C. Toulas,et al.  Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance , 2014, Cell Death and Disease.

[60]  Wei Fan,et al.  Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma , 2013, Oncology letters.

[61]  S. Mi,et al.  An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. , 2012, Human molecular genetics.

[62]  T. Mikkelsen,et al.  Phase I Study of Terameprocol in Patients with Recurrent High-grade Glioma Neuro-onco Lo Gy , 2022 .

[63]  Dae-Ho Lee,et al.  A Randomized Phase 3 Trial Comparing Pemetrexed/Carboplatin and Docetaxel/Carboplatin as First-Line Treatment for Advanced, Nonsquamous Non-small Cell Lung Cancer , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[64]  Ping Yang,et al.  Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. , 2008, Mayo Clinic proceedings.

[65]  M. Tan,et al.  Phase I/II clinical safety studies of terameprocol vaginal ointment. , 2007, Gynecologic oncology.

[66]  T. Tsuruo,et al.  Akt/Protein Kinase B-Dependent Phosphorylation and Inactivation of WEE1Hu Promote Cell Cycle Progression at G2/M Transition , 2005, Molecular and Cellular Biology.

[67]  Q. Tang,et al.  Gastrodin protects against cardiac hypertrophy and fibrosis , 2011, Molecular and Cellular Biochemistry.

[68]  Liu Shi-xi.  Gastrodin Injection in the Treatment of Vertigo: A Multi-center Single-blind Randomized Controlled Trial , 2004 .